The risk of gastrointestinal malignancies in cystic fibrosis. Case report of a patient with a near obstructing villous adenoma found on colon cancer screening and Barrett's esophagus

Journal of Cystic Fibrosis

Volumn 7, Issue 1, 2008, Pages 1-6

  Alexander, C L ^a   Urbanski, S J ^a   Hilsden, R ^a   Rabin, H ^a   MacNaughton, W K ^a   Beck, P L ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Adenoma; Barrett's esophagus; Colon cancer; Cystic fibrosis; Esophageal cancer; Screening; Small bowel cancer

Indexed keywords

ADULT; ANAMNESIS; BARRETT ESOPHAGUS; CANCER RISK; CANCER SCREENING; CASE REPORT; CLINICAL FEATURE; COLON BIOPSY; COLON CANCER; COLON POLYP; COLONOSCOPY; CYSTIC FIBROSIS; ENDOSCOPY; FAMILY HISTORY; HISTOPATHOLOGY; HUMAN; MALE; POLYPECTOMY; POSTOPERATIVE PERIOD; REVIEW; RISK BENEFIT ANALYSIS; TREATMENT REFUSAL; VILLOUS ADENOMA;

ADENOMA, VILLOUS; ADULT; BARRETT ESOPHAGUS; COLONOSCOPY; CYSTIC FIBROSIS; ENDOSCOPY, GASTROINTESTINAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ILEAL NEOPLASMS; MALE; RISK FACTORS;

EID: 38049027871     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcf.2007.07.005     Document Type: Review

References (43)

1. Neglia J.P., FitzSimmons S.C., Maisonneuve P., Schoni M.H., Schoni-Affolter F., Corey M., et al. The risk of cancer among patients with cystic fibrosis. Cystic Fibrosis and Cancer Study Group. N Engl J Med 332 8 (Feb 23 1995) 494-499
2. Maisonneuve P., FitzSimmons S.C., Neglia J.P., Campbell III P.W., and Lowenfels A.B. Cancer risk in nontransplanted and transplanted cystic fibrosis patients: a 10-year study. J Natl Cancer Inst 95 5 (Mar 5 2003) 381-387
3. Stefanidis D., Pollock B.H., Miranda J., Wong A., Sharkey F.E., Rousseau D.L., et al. Colorectal cancer in Hispanics: a population at risk for earlier onset, advanced disease, and decreased survival. Am J Clin Oncol 29 2 (Apr 2006) 123-126
4. Brown J.A., Chaun H., and Mason A.C. Delayed diagnosis of colon carcinoma in cystic fibrosis. Clin Radiol 55 3 (Mar 2000) 240-242
5. Neugut A.I., Jacobson J.S., Suh S., Mukherjee R., and Arber N. The epidemiology of cancer of the small bowel. Cancer Epidemiol Biomarkers Prev 7 3 (Mar 1998) 243-251
6. Redington A.N., Spring R., and Batten J.C. Adenocarcinoma of the ileum presenting as non-traumatic clostridial myonecrosis in cystic fibrosis. Br Med J (Clin Res Ed) 290 6485 (Jun 22 1985) 1871-1872
7. Siraganian P.A., Miller R.W., and Swender P.T. Cystic fibrosis and ileal carcinoma. Lancet 2 8568 (Nov 14 1987) 1158
8. Roberts J.A., Tullett W.M., Thomas J.S., Galloway D., and Stack B.H. Bowel adenocarcinoma in a patient with cystic fibrosis. Scott Med J 31 2 (Apr 1986) 109
9. Ledson M.J., Tran J., and Walshaw M.J. Prevalence and mechanisms of gastro-oesophageal reflux in adult cystic fibrosis patients. J R Soc Med 91 1 (Jan 1998) 7-9
10. Heine R.G., Button B.M., Olinsky A., Phelan P.D., and Catto-Smith A.G. Gastro-oesophageal reflux in infants under 6 months with cystic fibrosis. Arch Dis Child 78 1 (Jan 1998) 44-48
11. Malfroot A., and Dab I. New insights on gastro-oesophageal reflux in cystic fibrosis by longitudinal follow up. Arch Dis Child 66 11 (Nov 1991) 1339-1345
12. Dab I., and Malfroot A. Gastroesophageal reflux: a primary defect in cystic fibrosis?. Scand J Gastroenterol Suppl 143 (1988) 125-131
13. Tovar J.A., Olivares P., Diaz M., Pace R.A., Prieto G., and Molina M. Functional results of laparoscopic fundoplication in children. J Pediatr Gastroenterol Nutr 26 4 (Apr 1998) 429-431
14. Hassall E., Israel D.M., Davidson A.G., and Wong L.T. Barrett's esophagus in children with cystic fibrosis: not a coincidental association. Am J Gastroenterol 88 11 (Nov 1993) 1934-1938
15. Williams S.J., McGuckin M.A., Gotley D.C., Eyre H.J., Sutherland G.R., and Antalis T.M. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res 59 16 (Aug 15 1999) 4083-4089
16. Packer L.M., Williams S.J., Callaghan S., Gotley D.C., and McGuckin M.A. Expression of the cell surface mucin gene family in adenocarcinomas. Int J Oncol 25 4 (Oct 2004) 1119-1126
17. Puchelle E., Bajolet O., and Abely M. Airway mucus in cystic fibrosis. Paediatr Respir Rev 3 2 (Jun 2002) 115-119
18. Khatri I.A., Ho C., Specian R.D., and Forstner J.F. Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis. Am J Physiol Gastrointest Liver Physiol 280 6 (Jun 2001) G1321-G1330
19. Parmley R.R., and Gendler S.J. Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus. J Clin Invest 102 10 (Nov 15 1998) 1798-1806
20. Malmberg E.K., Noaksson K.A., Phillipson M., Johansson M.E., Hinojosa-Kurtzberg M., Holm L., et al. Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression. Am J Physiol Gastrointest Liver Physiol 291 2 (Aug 2006) G203-G210
21. De Lisle R.C., Roach E.A., and Norkina O. Eradication of small intestinal bacterial overgrowth in the cystic fibrosis mouse reduces mucus accumulation. J Pediatr Gastroenterol Nutr 42 1 (Jan 2006) 46-52
22. Gronowitz E., Pitkanen S., Kjellmer I., Heikinheimo M., and Strandvik B. Association between serum oncofetal antigens CA 19-9 and CA 125 and clinical status in patients with cystic fibrosis. Acta Paediatr 92 11 (Nov 2003) 1267-1271
23. Wilson G.B., Burdash N.M., Arnaud P., Monsher M.T., and Fudenberg H.H. Carcinoembryonic antigen and cystic fibrosis protein in blood from cystic fibrosis homozygotes and heterozygote carriers. Scand J Immunol 5 6-7 (1976) 829-836
24. Smyth R.L., Croft N.M., O'Hea U., Marshall T.G., and Ferguson A. Intestinal inflammation in cystic fibrosis. Arch Dis Child 82 5 (May 2000) 394-399
25. Croft N.M., Marshall T.G., and Ferguson A. Gut inflammation in children with cystic fibrosis on high-dose enzyme supplements. Lancet 346 8985 (Nov 11 1995) 1265-1267
26. Bruzzese E., Raia V., Gaudiello G., Polito G., Buccigrossi V., Formicola V., et al. Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration. Aliment Pharmacol Ther 20 7 (Oct 1 2004) 813-819
27. Norkina O., and De Lisle R.C. Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10. BMC Genet 6 1 (2005) 29
28. Bensalem N., Ventura A.P., Vallee B., Lipecka J., Tondelier D., Davezac N., et al. Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. Mol Cell Proteomics 4 10 (Oct 2005) 1591-1601
29. Briars G. Intestinal inflammation in cystic fibrosis. Arch Dis Child 84 4 (Apr 2001) 374-375
30. FitzSimmons S.C., Burkhart G.A., Borowitz D., Grand R.J., Hammerstrom T., Durie P.R., et al. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N Engl J Med 336 18 (May 1 1997) 1283-1289
31. Hausler M., Meilicke R., Biesterfeld S., and Heimann G. First adult patient with fibrosing colonopathy. Am J Gastroenterol 93 7 (Jul 1998) 1171-1172
32. Waldo S.W., Rosario H.S., Penn A.H., and Schmid-Schonbein G.W. Pancreatic digestive enzymes are potent generators of mediators for leukocyte activation and mortality. Shock (Augusta, Ga.) 20 2 (Aug 2003) 138-143
33. Butterworth A.S., Higgins J.P., and Pharoah P. Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis. Eur J Cancer 42 2 (Jan 2006) 216-227
34. Douglas J.A., Gruber S.B., Meister K.A., Bonner J., Watson P., Krush A.J., et al. History and molecular genetics of Lynch syndrome in family G: a century later. Jama 294 17 (Nov 2 2005) 2195-2202
35. Karlen P., Lofberg R., Brostrom O., Leijonmarck C.E., Hellers G., and Persson P.G. Increased risk of cancer in ulcerative colitis: a population-based cohort study. Am J Gastroenterol 94 4 (Apr 1999) 1047-1052
36. Eaden J.A., Abrams K.R., and Mayberry J.F. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48 4 (Apr 2001) 526-535
37. Jess T., Gamborg M., Matzen P., Munkholm P., and Sorensen T.I. Increased risk of intestinal cancer in Crohn's disease: a meta-analysis of population-based cohort studies. Am J Gastroenterol 100 12 (Dec 2005) 2724-2729
38. Card T.R., West J., and Holmes G.K. Risk of malignancy in diagnosed coeliac disease: a 24-year prospective, population-based, cohort study. Aliment Pharmacol Ther 20 7 (Oct 1 2004) 769-775
39. Lassen A., Hallas J., and de Muckadell O.B. Esophagitis: incidence and risk of esophageal adenocarcinoma-a population-based cohort study. Am J Gastroenterol 101 6 (Jun 2006) 1193-1199
40. Solaymani-Dodaran M., Logan R.F., West J., Card T., and Coupland C. Risk of oesophageal cancer in Barrett's oesophagus and gastro-oesophageal reflux. Gut 53 8 (Aug 2004) 1070-1074
41. Winawer S., Fletcher R., Rex D., Bond J., Burt R., Ferrucci J., et al. Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence. Gastroenterology 124 2 (Feb 2003) 544-560
42. Stefansson T., Moller P.H., Sigurdsson F., Steingrimsson E., and Eldon B.J. Familial risk of colon and rectal cancer in Iceland: evidence for different etiologic factors?. Int J Cancer 119 2 (Jul 15 2006) 304-308
43. Giardiello F.M., Brensinger J.D., Tersmette A.C., Goodman S.N., Petersen G.M., Booker S.V., et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 119 6 (Dec 2000) 1447-1453