Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates: Identification of potent 7-amino analogs

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 405-412

  Boschelli, Diane H ^a   Wu, Biqi ^a   Ye, Fei ^a   Durutlic, Haris ^a   Golas, Jennifer M ^a   Lucas, Judy ^a   Boschelli, Frank ^a  

^a WYETH RESEARCH   (United States)

Author keywords

3 Quinolinecarbonitrile; kinase; SKI 606; Src

Indexed keywords

4 PHENYLAMINO 3 QUINOLINECARBONITRILE DERIVATIVE; BOSUTINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; CELL LINE; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; NITRILES; PROTEIN KINASE INHIBITORS; QUINOLINES; RATS; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38049024511     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.09.028     Document Type: Article

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