Perturbed bone marrow monocyte development following burn injury and sepsis promote hyporesponsive monocytes

Journal of Burn Care and Research

Volumn 29, Issue 1, 2008, Pages 12-21

  Muthu, Kuzhali ^a   He, L K ^a   Melstrom, Kurt ^a   Szilagyi, Andrea ^a   Gamelli, Richard L ^a   Shankar, Ravi ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; BONE MARROW CELL; BURN; C57BL MOUSE; CELL HOMING; CELL MATURATION; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EXPERIMENTAL MOUSE; HEMATOPOIETIC STEM CELL; HYPOTHESIS; IMMUNOSUPPRESSIVE TREATMENT; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; SCALD; SEPSIS;

ANIMALS; BONE MARROW; BURNS; CYTOKINES; DENDRITIC CELLS; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; SEPSIS;

EID: 38049007982     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e31815fa499     Document Type: Article

References (44)

1. Lederer JA, Rodrick ML, Mannick JA. The effects of injury on the adaptive immune response. Shock 1999;11:153-9.
2. Oberholzer A, Oberholzer C, Moldawer LL. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 2001;16:83-96.
3. Faist E, Schinkel C, Zimmer S, Kremer JP, Von Donnersmarck GH, Schildberg FW. Inadequate interleukin-2 synthesis and interleukin-2 messenger expression following thermal and mechanical trauma in humans is caused by defective transmembrane signalling. J Trauma 1993;34:846-53; discussion 853-4.
4. Miller CL, Baker CC. Changes in lymphocyte activity after thermal injury. The role of suppressor cells. J Clin Invest 1979;63:202-10.
5. Miller-Graziano CL, Szabo G, Kodys K, Griffey K. Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome. J Trauma 1990;30:S86-96.
6. Ayala A, Chaudry IH. Immune dysfunction in murine polymicrobial sepsis: mediators, macrophages, lymphocytes and apoptosis. Shock 1996;6(Suppl 1):S27-38.
7. Mosser DM. The many faces of macrophage activation. J Leukoc Biol 2003;73:209-12.
8. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003;3:23-35.
9. Simpson SQ, Modi HN, Balk RA, Bone RC, Casey LC. Reduced alveolar macrophage production of tumor necrosis factor during sepsis in mice and men. Crit Care Med 1991;19:1060-6.
10. McCall CE, Grosso-Wilmoth LM, LaRue K, Guzman RN, Cousart SL. Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome. J Clin Invest 1993;91:853-61.
11. Carreras MC, Catz SD, Pargament GA, Del Bosco CG, Poderoso JJ. Decreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome. Comparison with endotoxin and cytokine effects on normal cells. Inflammation 1994;18:151-61.
12. Marie C, Muret J, Fitting C, Losser MR, Payen D, Cavaillon JM. Reduced ex vivo interleukin-8 production by neutrophils in septic and nonseptic systemic inflammatory response syndrome. Blood 1998;91:3439-46.
13. Bone RC. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med 1996;125:680-7.
14. Volk HD, Reinke P, Krausch D, et al. Monocyte deactivation-rationale for a new therapeutic strategy in sepsis. Intensive Care Med 1996;22(Suppl 4:)S474-81.
15. Docke WD, Randow F, Syrbe U, et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997;3:678-81.
16. Volk HD, Thieme M, Heym S, et al. Alterations in function and phenotype of monocytes from patients with septic disease-predictive value and new therapeutic strategies. Behring Inst Mitt 1991:208-15.
17. Munoz C, Carlet J, Fitting C, Misset B, Bleriot JP, Cavaillon JM. Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991;88:1747-54.
18. Miller-Graziano CL, Zhu D, Kodys K. Differential induction of human monocyte transforming growth factor beta 1 production and its regulation by interleukin 4. J Clin Immunol 1994;14:61-72.
19. Szabo G, Kodys K, Miller-Graziano CL. Elevated monocyte interleukin-6 (IL-6) production in immunosppressed trauma patients. II. Downregulation by IL-4 J Clin Immunol 1991;11:336-44.
20. Faist E. The mechanisms of host defense dysfunction following shock and trauma. Curr Top Microbiol Immunol 1996;216:259-74.
21. Takahashi K, Naito M, Takeya M. Development and heterogeneity of macrophages and their related cells through their differentiation pathways. Pathol Int 1996;46:473-85.
22. Yamamoto T, Naito M, Moriyama H, et al. Repopulation of murine Kupffer cells after intravenous administration of liposome-encapsulated dichloromethylene diphosphonate. Am J Pathol 1996;149:1271-86.
23. Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003;19:71-82.
24. Xu H, Manivannan A, Dawson R, et al. Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators. J Immunol 2005;175:6915-23.
25. Sunderkotter C, Nikolic T, Dillon MJ, et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol 2004;172:4410-7.
26. Walker HL, Mason AD Jr. A standard animal burn. J Trauma 1968;8:1049-51.
27. Fogg DK, Sibon C, Miled C, et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 2006;311:83-7.
28. Efron P, Moldawer LL. Sepsis and the dendritic cell. Shock 2003;20:386-401.
29. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
30. Kelsall BL, Biron CA, Sharma O, Kaye PM. Dendritic cells at the host-pathogen interface. Nat Immunol 2002;3:699-702.
31. Hotchkiss RS, Tinsley KW, Swanson PE, et al. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 2002;168:2493-500.
32. Baue AE, Durham R, Faist E. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock 1998;10:79-89.
33. Gogos CA, Drosou E, Bassaris HP, Skoutelis A. Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis 2000;181:176-80.
34. Chaudry IH. Sepsis: lessons learned in the last century and future directions. Arch Surg 1999;134:922-9.
35. Gibbons RA, Martinez OM, Lim RC, Horn JK, Garovoy MR. Reduction in HLA-DR, HLA-DQ and HLA-DP expression by Leu-M3+ cells from the peripheral blood of patients with thermal injury Clin Exp Immunol 1989;75:371-5.
36. Zwadlo-Klarwasser G, Kauhl W, Schmitz C, Hettich R. Influence of severe burn injury on the expression of RM 3/1 and HLA-DR antigens in human blood monocytes. J Burn Care Rehabil 1996;17:287-93.
37. Hotchkiss RS, Tinsley KW, Karl IE. Role of apoptotic cell death in sepsis. Scand J Infect Dis 2003;35:585-92.
38. Tinsley KW, Grayson MH, Swanson PE, et al. Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol 2003;171:909 -14.
39. Rotta G, Edwards EW, Sangaletti S, et al. Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo. J Exp Med 2003;198:1253-63.
40. Huang Z, Pereira C, Toliver-Kinsky T, et al. Effect of transforming growth factor-beta neutralization on survival and bacterial clearance in a murine model of Pseudomonas aeruginosa burn wound infection. J Burn Care Res 2006;27:682-7.
41. Muthu K, Deng J, Gamelli R, Shankar R, Jones SB. Adrenergic modulation of cytokine release in bone marrow progenitor-derived macrophage following polymicrobial sepsis. J Neuroimmunol 2005;158:50-7.
42. Muthu K, Deng J, Romano F, et al. Thermal injury and sepsis modulates beta-adrenergic receptors and cAMP responses in monocyte-committed bone marrow cells. J Neuroimmunol 2005;165:129-38.
43. Muthu K, Iyer S, He LK, et al. Murine hematopoietic stem cells and progenitors express adrenergic receptors. J Neuroimmunol 2007;186:27-36.
44. Cohen M, Stevenson R, Fernandez R, Gamelli RL, Jones SB. Bone marrow norepinephrine mediates development of functionally different macrophages following thermal injury and sepsis. Ann Surg 2004.