MELAS masquerading as a systemic vasculitis

Journal of Clinical Rheumatology

Volumn 13, Issue 6, 2007, Pages 334-337

  Carroll, Matthew B ^a,b  

^a WILFORD HALL MEDICAL CENTER   (United States)

^b USAF Medical Center Keesler   (United States)

Author keywords

Encephalopathy; Headache; Lactic acidosis; MELAS; Ragged red fibers; Stroke like events; Systemic vasculitis

Indexed keywords

C REACTIVE PROTEIN; CARNITINE; CREATININE; HEMOGLOBIN; IMMUNOGLOBULIN; LACTIC ACID;

ADULT; ANOREXIA; ARTICLE; BLINDNESS; BRAIN BIOPSY; CASE REPORT; CONSTIPATION; DIARRHEA; DISEASE ASSOCIATION; ELECTROENCEPHALOGRAPHY; EPILEPTIC DISCHARGE; FECES IMPACTION; GASTROINTESTINAL BIOPSY; HEADACHE; HUMAN; HUMAN TISSUE; LACTATE BLOOD LEVEL; LEUKOCYTOSIS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MELAS SYNDROME; NAUSEA; NUCLEAR MAGNETIC RESONANCE IMAGING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; SIGMOID VOLVULUS; SYSTEMIC VASCULITIS; UREA NITROGEN BLOOD LEVEL; VOMITING;

ADULT; BIOPSY; DIAGNOSIS, DIFFERENTIAL; DNA, MITOCHONDRIAL; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MELAS SYNDROME; POINT MUTATION; VASCULITIS, CENTRAL NERVOUS SYSTEM;

EID: 37849038090     PISSN: 10761608     EISSN: None     Source Type: Journal    
DOI: 10.1097/RHU.0b013e31815c2516     Document Type: Article

References (11)

1. DiMauro S, Hirano M. MELAS [Myopathy, mitochondrial-encephalopathy-lactic acidosis-stroke; mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes]. October 13, 2005. Available at http://www.geneclinics.org. Accessed May 15, 2006.
2. Kirino Y, Yasukawa T, Ohta S, et al. Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. PNAS. 2004;101:15070-15075.
3. Chinnery PF, Schon EA. Mitochondria. J Neurol Neurosurg Psychiatry. 2003;74:1188-1199.
4. Gilchrist JM, Sikirica M, Stopa E, Shanske S. Adult-onset MELAS. Evidence for involvement of neurons as well as cerebral vasculature in strokelike episodes. Stroke. 1996;27:1420-1423.
5. Hirano M, Ricci E, Koenigsberger MR, et al. MELAS: an original case and clinical criteria for diagnosis. Neuromuscul Disord. 1992;2:125-135.
6. DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. N Engl J Med. 2003;348:2656-2668.
7. Oppenheim C, Galanaud D, Samson Y, et al. Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like events in MELAS? J Neurol Neurosurg Psychiatry. 2000;69:248-250.
8. Dickerson BC, Holtzman D, Grant PE, Tian D. Case 36-2005: a woman with seizure, disturbed gait, and altered mental status. N Engl J Med. 2005;353:2271-2280.
9. Matsumoto J, Saver JL, Brennan KC, et al. Mitochondrial encephalopathy with lactic acidosis and stroke (MELAS). Rev Neurol Dis. 2005;2:30-34.
10. Geberhiwot T, Chakrapani A, Hendriksz C. Case 36-2005: A woman with seizure, disturbed gait, and altered mental status (correspondence). N Engl J Med. 2006;354:1096-1097.
11. Kaufmann P, Englestad K, Wei Y, et al. Dichloroacetate causes toxic neuropathy in MELAS. Neurology. 2006;66:324-330.