CD4+CD25+ lymphocyte subsets in chronic graft versus host disease patients undergoing extracorporeal photochemotherapy

International Journal of Immunopathology and Pharmacology

Volumn 20, Issue 4, 2007, Pages 801-807

  Rubegni, Pietro ^a   Sbano, P ^a   Cevenini, G ^a   Perari, M G ^a   Marotta, G ^a   Risulo, M ^a   Carcagni M R ^a   D'Ascenzo, G ^a   De Aloe, G ^a   Fimiani, M ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

CD4+CD25+ T lymphocytes; Extracorporeal photochemotherapy; Graft vs host disease; Regulatory T cells; UV

Indexed keywords

ADULT; ARTICLE; BLOOD CHEMISTRY; CD4+ CD25+ T LYMPHOCYTE; CELL COUNT; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL ARTICLE; CLINICAL EXAMINATION; CYTOFLUOROMETRY; FEMALE; HUMAN; MALE; PHENOTYPE; PHOTOCHEMOTHERAPY; PRIORITY JOURNAL; SAMPLING; TREATMENT OUTCOME;

EID: 37749028085     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200702000416     Document Type: Article

References (14)

1. Horwitz M.E. and K.M. Sullivan. 2006. Chronic graft-versus-host disease. Blood Rev. 20:15.
2. Foss F.M., G. Gorgun and K.B. Miller. 2002. Extracorporeal photopheresis in chronic graft-versus-host disease. Bone Marrow Transplant 29:719.
3. Dall'Amico R. and C. Messina. 2002. Extracorporeal photochemotherapy for the treatment of graft-versus-host disease. Ther. Apher. 6:296.
4. Rubegni P., A. Cuccia, P. Sbano et al. 2005. Role of extracorporeal photochemotherapy in patients with refractory chronic graft-versus-host disease. Br. J. Haematol. 130:271.
5. Fimiani M., M. Di Renzo and P. Rubegni. 2004. Mechanism of action of extracorporeal photochemotherapy in chronic graft-versus-host disease. Br. J. Dermatol. 150:1055.
6. Cohen J.L., A. Trenado, D. Vasey, D. Klatzmann and B.L. Salomon. 2002. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196:401.
7. Taylor P.A., C.J. Lees and B.R. Blazar. 2002. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99:3493.
8. Lamioni A., F. Parisi, G. Isacchi, E. Giorda, S. Di Cesare, A. Landolfo, F. Cenci, G.F. Bottazzo and R. Carsetti. 2005. The immunological effects of extracorporeal photopheresis unraveled: induction of tolerogenic dendritic cells in vitro and regulatory T cells in vivo. Transplantation 79:846.
9. Maeda A., A. Schwarz, K. Kernebeck, N. Gross, Y. Aragane, D. Peritt and T. Schwarz. 2005. Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells. J. Immunol. 174:5968.
10. Kleinclauss F., S. Perruche, E. Masson, M. de Carvalho Bittencourt, S. Biichle, J.P. Remy-Martin, C. Ferrand, M. Martin, H. Bittard, J.M. Chalopin, E. Seilles, P. Tiberghien and P. Saas. 2006. Intravenous apoptotic spleen cell infusion induces a TGF-beta-dependent regulatory T-cell expansion. Cell Death Differ. 13:41.
11. Di Renzo M., P. Rubegni, P. Sbano, A. Cuccia, C. Castagnini, G. Pompella, A.L. Pasqui, P.L. Capecchi, A. Auteri, F. Laghi Pasini and M. Fimiani. 2003. ECP-treated lymphocytes of chronic graft-versus-host disease patients undergo apoptosis which involves both the Fas/FasL system and the Bcl-2 protein family. Arch. Dermatol. Res. 295:175.
12. Spisek R., Z. Gasova and J. Bartunkova. 2006. Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graft-versus-host disease. Transfusion 46:55.
13. Ferguson T.A., P.M. Stuart, J.M. Herndon and T.S. Griffith. 2003. Apoptosis, tolerance, and regulatory T cells - old wine, new wineskins. Immunol. Rev. 193:111.
14. Edinger M., P. Hoffmann, J. Ermann, K. Drago, C.G. Fathman, S. Strober and R.S. Negrin. 2003. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9:1144.