Interaction of intracellular signalling and metabolic pathways at inhibition of mitochondrial aconitase by fluoroacetate

Cell and Tissue Biology

Volumn 1, Issue 6, 2007, Pages 541-550

  Zinchenko, V P ^a   Goncharov, N V ^b   Teplova, V V ^c   Kasymov, V A ^a   Petrova, O I ^a   Berezhnov, A V ^a   Senchenkov, E V ^b   Mindukshev, I V ^d   Jenkins, R O ^e   Radilov, A S ^b  

^a INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

^b Research Institute of Hygiene Occupational Pathology and Human Ecology   (Russian Federation)

^c INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

^d SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^e DE MONTFORT UNIVERSITY   (United Kingdom)

Author keywords

Fluoroacetate; Intracellular calcium; Membrane potential; Mitochondria; Pyridine nucleotides

Indexed keywords

RATTUS;

EID: 37749021614     PISSN: 1990519X     EISSN: 19905203     Source Type: Journal    
DOI: 10.1134/S1990519X07060119     Document Type: Article

References (62)

1. Andersson, U., Leighton, B., Young, M.E., Blomstrand, E, and Newsholme, E.A., Inactivation of Aconitase and Oxoglutarate Dehydrogenase in Skeletal Muscle in vitro by Superoxide Anions and/or Nitric Oxide, Biochem. Biophys. Res. Commun., 1998, vol. 249, pp. 512-516.
2. Arena, I.M., Poisoning: Toxicology-Symptoms-Treatments, Springfield: C.C. Thomas Verlag, 1970.
3. 2+ Homeostasis in Ehrlich and Yoshida Carcinomas, J. Biol. Chem., 1985, vol. 260, pp. 2719-2727.
4. Bannister, D.W. and O'Neill, I.E., Control of Gluconeogenesis in Chick (Gallus domesticus) Isolated Hepatocytes: Effect of Redox State and Phosphoenolpyruvate Carboxykinase (EC 4.1.1.32) Location, Int. J. Biochem., 1981, vol. 13, pp. 437-444.
5. Bobyleva, V., Kneer, N., Bellei, M., Battelli, D., and Lardy, H.A., Concerning the Mechanism of Increased Thermogenesis in Rats Treated with Dehydroepiandrosterone, J. Bioenerg. Biomembr., 1993, vol. 25, pp. 313-321.
6. Bowman, R.H., Inhibition of Citrate Metabolism by Sodium Fluoroacetate in the Perfused Rat Heart and the Effect on Phosphofructokinase Activity and Glucose Utilization, Biochem. J., 1964, vol. 93, pp. 13-15.
7. Buffa, P. and Pasquali-Ronchetti, I., Biochemical Lesions of Respiratory Enzymes and Configurational Changes of Mitochondria in vivo. II. Early Ultrastructural Modifications Correlated to the Biochemical Lesion Induced by Fluoroacetate, Cell Tissue Res., 1977, vol. 183, pp. 1-23.
8. Buffa, P. and Peters, R.A., The in vivo Formation of Citrate Induced by Fluoroacetate Poisoning and Its Significance, J. Physiol., 1950, vol. 110, pp. 488-500.
9. Buffa, P., Guarriero-Bobyleva, V., and Pasquali-Ronchetti, J., Biochemical Effects of Fluoroacetate Poisoning in Rat Liver, Carbone-Fluorine Compounds, Amsterdam: Associated Scientific Compounds, 1972, pp. 303-330.
10. Buffa, P., Guarriero-Bobyleva, V., and Costa-Tiozzo, R., Metabolic Effects of Fluoroacetate Poisoning in Animals, Fluoride, 1973, vol. 6, pp. 224-247.
11. Cole, B.T., Engel, F.L., and Fredericks, J., Sodium Fluoroacetate Diabetes: Correlations between Glycemia, Ketonemia and Tissue Citrate Levels, Endocrinology, 1955, vol. 56, pp. 675-683.
12. Corsi, A. and Granata, A.L., Differential Toxicity of Fluoroacetate to Heart, Kidney and Brain Mitochondria of the Living Rat, Biochem. Pharmacol., 1967, vol. 16, pp. 1083-1089.
13. Cremer-Lacuara, M.G., Lacuara, J.L., Fiol de Cuneo, M., and Ruiz, R.D., Substrate Supply and Function of Isolated Venous Smooth Muscle under Anoxia and Metabolic Inhibition, Can. J. Physiol. Pharmacol., 1980, vol. 58, pp. 723-730.
14. Dickson, A.J. and Langslow, D.R., Gluconeogenesis in Isolated Chicken Hepatocytes, Biochem. Soc. Trans., 1977, vol. 5, pp. 983-986.
15. Dohi, T. and Murad, F., Effects of Pyruvate and Other Metabolites on Cyclic GMP Levels in Incubations of Rat Hepatocytes and Kidney Cortex, Biochim. Biophys. Acta, 1981, vol. 673, pp. 14-25.
16. Evtodienko, Yu.V., Azarashvili, T.S., Teplova, V.V., Odinokova, I.V., and Saris, N.-E., Regulation of Oxidative Phosphorylation in the Inner Membrane of Rat Liver Mitochondria by Calcium Ions, Biokhimiya, 2000, vol. 65, no. 9, pp. 1023-1026.
17. Fairhurst, A.S., Smith, R.E., and Gal, B.M., The Effects of Fluorocompounds on Oxidative Phosphorylation, Biochem. Pharmacol., 1958, vol. 1, pp. 273-279.
18. Frank, G.M., Kondrashova, M.N., Mokhova, E.N., and Rotenberg, Yu.S., Rukovodstvo po izucheniyu biologicheskogo okisleniya polarograficheskim metodom (Manual of Study of Biological Oxidation by Polarographical Method), Moscow: Nauka, 1973.
19. Gardner, P.R., Nguyen, D.D., and White, C.W., Aconitase Is a Sensitive and Critical Target of Oxygen Poisoning in Cultured Mammalian Cells and in Rat Lungs, Proc. Natl. Acad. Sci. USA, 1994, vol. 91, pp. 12 248-12 252.
20. Goncharov, N.V., Jenkins, R.O., and Radilov, A.S., Toxicology of Fluoroacetate: A Review, with Possible Directions for Therapy Research, J. Appl. Toxicol., 2006, vol. 26, pp. 148-161.
21. Gupte, S.A. and Wolin, M.S., Hypoxia Promotes Relaxation of Bovine Coronary Arteries through Lowering Cytosolic NADPH, Am. J. Physiol. Heart Circ. Physiol., 2006, vol. 290, pp. H2228-H2238.
22. Hansford, R., Role of Calcium in Respiratory Control, Medic. Sci. Sports Exercise, vol. 1994, vol. 26, pp. 44-51.
23. 2+-Channels TRPV5 and TRPV6, EMBO J., 2003, vol. 22, pp. 776-785.
24. Hubbard, M.J. and McHugh, N.J., Mitochondrial ATP Synthase F-1-Beta-subunit is a Calcium-binding Protein, FEBS Lett., 1996, vol. 391, pp. 323-329.
25. James, E.A., Gygi, S.P., Adams, M.L., Pierce, R.H., Fausto, N., Aebersold, R.H., Nelson, S.D., and Bruschi, S.A., Mitochondrial Aconitase Modification, Functional Inhibition, and Evidence for a Supramolecular Complex of the TCA Cycle by the Renal Toxicant S-(1,1,2,2-Tetrafluoroethyl)-L-cysteine, Biochemistry, 2002, vol. 41, pp. 6789-6797.
26. 2+ Ions on Transmembrane Electrical Potential, Synthesis and Hydrolysis of ATP in Brain Mitochondria, Biofizika, 1988, vol. 33, no. 1, pp. 77-82.
27. Khodorov, B., Glutamate-induced Deregulation of Calcium Homeostasis and Mitochondrial Dysfunction in Mammalian Central Neurons, Prog. Biophys. Mol. Biol., 2004, vol. 86, pp. 279-351.
28. Koenig, H. and Patel, A., Biochemical Basis for Fluorouracil Neurotoxicity: The Role of Krebs Cycle Inhibition by Fluoroacetate, Arch. Neurol., 1970, vol. 23, pp. 155-160.
29. Konstantinova, S.G. and Russanov, E.M., Aconitase Activity in Rat Liver, Comp. Biochem. Physiol. B: Biochem. Mol. Biol., 1996, vol. 113, pp. 125-130.
30. +-ICDH) on Cellular Defense against Oxidative Injury by Gamma-rays, Int. J. Radiat. Biol., 2004, vol. 80, pp. 635-642.
31. Lee, T.J. and Yu, J.G., L-Citrulline Recycle for Synthesis of NO in Cerebral Perivascular Nerves and Endothelial Cells, Ann. N.Y. Acad. Sci., 2002, vol. 962, pp. 73-80.
32. Li, Q.Y., Pedersen, C., Day, B.J., and Patel, M., Dependence of Excitotoxic Neurodegeneration on Mitochondrial Aconitase Inactivation, J. Neurochem., 2001, vol. 78, pp. 746-755.
33. Lee, S.M., Koh, H.J., Park, D.C., Song, B.J., Huh, T.L., and Park, J.W., Cytosolic NADP(+)-dependent Isocitrate Dehydrogenase Status Modulates Oxidative Damage to Cells, Free Rad. Biol. Med., 2002, vol. 32, pp. 1185-1196.
34. Lian, X.Y. and Stringer, J.L., Astrocytes Contribute to Regulation of Extracellular Calcium and Potassium in the Rat Cerebral Cortex during Spreading Depression, Brain Res., 2004, vol. 1012, pp. 177-184.
35. Liang, C., Metabolic Control of Circulation: Effects of Iodoacetate and Fluoroacetate, J. Clin. Invest., 1977, vol. 60, pp. 61-69.
36. Max, S.R. and Purvis, J.L., Energy-linked Incorporation of Citrate into Rat Liver Mitochondria, Biochem. Biophys. Res. Commun., 1965, vol. 21, pp. 587-594.
37. McCormack, J., Halestrap, A., and Denton, R., Role of Calcium Ions in Regulation of Mammalian Intramitochondrial Metabolism, Physiol. Rev., 1990, vol. 70, pp. 391-425.
38. Mindukshev, I.V., Goncharov, N.V., Shabanova, E.Yu., Ermolaeva, E.E., Mironova, M.O., Radilov, A.S., Jenkins, R.O., and Krivchenko, A.I., A New Method for Studying Platelets, Based upon the Low-angle Light Scattering Technique. 3. Aggregation Hypersensitivity of Platelets (ADP Agonist) and Search for Corrective Agents, Spectroscopy, 2006, vol. 20, pp. 57-66
39. Minich, T., Yokota, S., and Dringen, R., Cytosolic and Mitochondrial Isoforms of NADP+-dependent Isocitrate Dehydrogenases are Expressed in Cultured Rat Neurons, Astrocytes, Oligodendrocytes and Microglial Cells, J. Neurochem., 2003, vol. 86, pp. 605-614.
40. Parekh, A.B. and Penner, R., Store-operated Calcium Influx, Physiol. Rev., 1997, vol. 77, pp. 901-930.
41. Parekh, A.B. and Putney, J.W., Jr., Store-operated Calcium Channels, Physiol. Rev., 2005, vol. 85, pp. 757-810.
42. Pattison, F.L.M., Toxic Alifatic Fluorine Compounds, Amsterdam,: Elsevier Publishing Company, 1959.
43. Perez, G.A. and Frindt, G., The Effect of Fluorocitrate on Urinary Calcium and Citrate Excretion, Experientia, 1977, vol. 33, pp. 741-742.
44. Peters, R.A., Some Metabolic Aspects of Fluoroacetate Especially Related to Fluorocitrate, Carbon Fluorine-ompounds, A Ciba Foundation Symposium. Amsterdam: Associated Scientific Pub., 1972, pp. 55-70.
45. Powell, T., Terrar, D.A., and Twist, V.W., Electrical Properties of Individual Cells Isolated from Adult Rat Ventricular Myocardium, J. Physiol. 1980, vol. 302, pp. 131-153.
46. Rakhmanova, T.I. and Popova, T.N., Regulation of 2-Oxoglutarate Metabolism in Rat Liver under Effect of NADP-isocitrate Dehydrogenase and Aspartate Aminotransferase, Biokhimiya, 2006, vol. 71, no. 2, pp. 266-274.
47. Roy (Shapira), A., Taitelman, U., and Bursztein, S., Evaluation of the Role of Ionized Calcium in Sodium Fluoroacetate ('1080') Poisoning, Toxicol. Appl. Pharmacol., 1980, vol. 56, pp. 216-220.
48. Schneider, W.C., Intracellular Distribution of Enzymes, J. Biol. Chem., 1948, vol. 176, pp. 259-266.
49. Stewart, G.G., Abbs, E.T., and Roberts, D.J., Biochemical Effects of Fluoroacetate Administration in Rat Brain, Heart and Blood, Biochem. Pharmacol., 1970, vol. 19, pp. 1861-1866.
50. Taylor, W.M., D'Costa, M., Angel, A., and Halperin, M.L., Insulin-like Effects of Fluoroacetate on Lipolysis and Lipogenesis in Adipose Tissue, Can. J. Biochem., 1977, vol. 55, pp. 982-987.
51. Teplova, V.V., Zinchenko, V.P., and Evtodienko, Yu.V., The Role of Membrane-bound Calcium in Inhibition of Oxidative Phosphorylation in Ehrlich Ascites Tumor Cells, Studia biophysica, 1985, vol. 109, pp. 65-72.
52. 2+ Transport in Liver Cell Mitochondria, Tsitologiya, 1992, vol. 34, no. 11/12, pp. 69-73.
53. Twigg, L.E., Mead, R.J., and King, D.R., Metabolism of Fluoroacetate in the Skink (Tiliqua rugosa) and the rat (Rattus norvegicus), Aust. J. Biol. Sci., 1986, vol. 39, pp. 1-15.
54. Van Abel, M., Hoenderop, J.G., and Bindels, R.J., The Epithelial Calcium Channels TRPV5 and TRPV6: Regulation and Implications for Disease, Naun. Schmied. Arch. Pharmacol., 2005, vol. 371, pp. 295-306.
55. 2+ Channels TRPV5 and TRPV6 to the Plasma Membrane, Mol. Cell Biol., 2006, vol. 26, pp. 3-12.
56. Vogel, R., Wiesinger, H., Hamprecht, B., and Dringen, R., The Regeneration of Reduced Glutathione in Rat Forebrain Mitochondria Identifies Metabolic Pathways Providing the NADPH Required, Neurosci. Letts., 1999, vol. 275, pp. 97-100.
57. Winkler, B.S., De Santis, N., and Solomon, F., Multiple NADPH-producing Pathways Control Glutathione (GSH) Content in Retina, Exp. Eye Res., 1986, vol. 43, pp. 829-847.
58. Wolin, M.S., Ahmad, M., and Gupte, S.A., Oxidant and Redox Signaling in Vascular Oxygen Sensing Mechanisms: Basic Concepts, Current Controversies, and Potential Importance of Cytosolic NADPH, Am. J. Physiol. Lung Cell Mol. Physiol., 2005, vol. 289, pp. L159-L173.
59. Yu, H.L., Giammarco, R., Goldstein, M.B., Stinebaugh, D.J., and Halperin, M.L., Stimulation of Ammonia Production and Excretion in the Rabbit by Inorganic Phosphate: Study of Control Mechanisms, J. Clin. Invest., 1976, vol. 58, pp. 557-564.
60. Zinchenko, V.P., Teplova, V.V., and Evtodienko Yu.V., Kinetics of Oxygen Consumption, Luminescence of Pyridine Nucleotides and Cyanine Dye 3',3'-Diethyldocarbocyanine Iodide during Energization of Ehrlich Ascitic Carcinoma Cells by Glucose, Byull. Eksp. Biol. Med., 1982, vol. 44, no. 11, pp. 60-72.
61. 2+ Changes in Mitochondria of Ehrlich Ascites Tumor Cells, Calcium Signaling, New-York, Amsterdam. IOS Press, NATO Science Series, Series 1: Life and Behavioral Sciences, 2001, pp. 331, pp. 217-225
62. Zorov, D.B., Filburn, C.R., Klotz, L.O., Zweier, J.L., and Sollott, S.J., Reactive Oxygen Species (ROS)-induced ROS Release: A New Phenomenon Accompanying Induction of the Mitochondrial Permeability Transition in Cardiac Myocytes, J. Exp. Med., 2000, vol. 192, pp. 1001-1014.