Preoptic neuronal nitric oxide synthase induction by testosterone is consistent with a role in gating male copulatory behavior

European Journal of Neuroscience

Volumn 27, Issue 1, 2008, Pages 183-190

  Sanderson, Nicholas S R ^a   Le, Brandon ^a   Zhou, Zifei ^a   Crews, David ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Anteroventral periventricular preoptic area; Cnemidophorus inornatus; In situ hybridization; Laser microdissection; NADPH diaphorase histochemistry

Indexed keywords

ANDROGEN; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CASTRATION; CNEMIDOPHORUS INORNATUS; CONTROLLED STUDY; COPULATION; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOCHEMISTRY; HORMONAL REGULATION; IN SITU HYBRIDIZATION; LASER MICRODISSECTION; LIZARD; MALE; MALE GENITAL SYSTEM; MEASUREMENT; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREOPTIC AREA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STIMULUS RESPONSE; TESTIS; UPREGULATION;

ANALYSIS OF VARIANCE; ANDROGENS; ANIMALS; BEHAVIOR, ANIMAL; CELL COUNT; COPULATION; MALE; NADPH DEHYDROGENASE; NEURONS; NITRIC OXIDE SYNTHASE; PREOPTIC AREA; RATS; TESTOSTERONE; TIME FACTORS; UP-REGULATION;

EID: 37749000348     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2007.05989.x     Document Type: Article

References (25)

1. Crews, D. (2005) Evolution of neuroendocrine mechanisms that regulate sexual behavior. Trends Endocrinol. Metab., 16, 354 361.
2. Du, J. Hull, E.M. (1999) Effects of testosterone on neuronal nitric oxide synthase and tyrosine hydroxylase. Brain Res., 836, 90 98.
3. Gammie, S.C. Nelson, R.J. (2000) Maternal and mating-induced aggression is associated with elevated citrulline immunoreactivity in the paraventricular nucleus in prairie voles. J. Comp. Neurol., 418, 182 192.
4. Hull, E.M. Dominguez, J.M. (2006) Getting his act together, roles of glutamate, nitric oxide, and dopamine in the medial preoptic area. Brain Res., 1126, 66 75.
5. Hull, E.M., Meisel, R.L. Sachs, B.D. (2002) Male sexual behavior. In : Pfaff, D.W., Arnold, A.P., Etgen, A.M., Fahrbach, S.E. Rubin, R.T. (Eds), Hormones, Brain and Behavior, Vol. 1. Academic Press, San Diego, pp. 3 137.
6. Ishihara, T., Orikasa, C., Araki, T. Sakuma, Y. (2002) Sex difference in the expression and regulation of nitric oxide synthase gene in the rat preoptic area. Neurosci. Res., 43, 147 154.
7. Ketterson, E.D., Nolan, V. Jr., Wolf, L., Ziegenfus, C., Dufty, A.M. Jr., Ball, G.F. Johnsen, T.S. (1991) Testosterone and avian life histories: the effect of experimentally elevated testosterone on corticosterone and body mass in dark-eyed juncos. Horm. Behav., 25, 489 503.
8. Lamar, C.A., Bhat, G.K., Mahesh, V.B. Brann, D.W. (1999) Evidence that neuronal nitric oxide synthase but not heme oxygenase increases in the hypothalamus on proestrus afternoon. Neuroendocrinology, 70, 360 367.
9. Lindzey, J. Crews, D. (1986) Hormonal control of courtship and copulatory behavior in male Cnemidophorus inornatus, a direct sexual ancestor of a unisexual, parthenogenetic lizard. Gen. Comp. Endocrinol., 64, 411 418.
10. McCann, S.M., Haens, G., Mastronardi, C., Walczewska, A., Karanth, S., Rettori, V. Yu, W.H. (2003) The role of nitric oxide (NO) in control of LHRH release that mediates gonadotropin release and sexual behavior. Curr. Pharm. Des., 9, 381 390.
11. Park, K.H., Kim, S.W., Kim, K.D. Paick, J.S. (1999) Effects of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernosum. BJU Int., 83, 327 333.
12. Park, C.S., Krishna, G., Ahn, M.S., Kang, J.H., Chung, W.G., Kim, D.J., Hwang, H.K., Lee, J.N., Paik, S.G. Cha, Y.N. (2000) Differential and constitutive expression of neuronal, inducible, and endothelial nitric oxide synthase mRNAs and proteins in pathologically normal human tissues. Nitric Oxide, 4, 459 471.
13. Putnam, S.K., Sato, S., Riolo, J.V. Hull, E.M. (2005) Effects of testosterone metabolites on copulation, medial preoptic dopamine, and NOS-immunoreactivity in castrated male rats. Horm. Behav., 47, 513 522.
14. Sambrook, J. Russell, D.W. (2001) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
15. Sanderson, N.S., Le, B.D. Crews, D. (2006) Testosterone induction of male-typical sexual behavior is associated with increased preoptic NADPH diaphorase and citrulline production in female whiptail lizards. J. Neurobiol., 66, 1156 1163.
16. Sanderson, N.S., Weissler, E. Crews, D. (2005) The nitric oxide synthase inhibitor L-NAME suppresses androgen-induced male-like pseudocopulatory behavior in whiptail lizards. Brain Res., 1052, 236 239.
17. Sato, S., Braham, C.S., Putnam, S.K. Hull, E.M. (2005) Neuronal nitric oxide synthase and gonadal steroid interaction in the MPOA of male rats: co-localization and testosterone-induced restoration of copulation and nNOS-immunoreactivity. Brain Res., 1043, 205 213.
18. Sato, T., Matsumoto, T., Kawano, H., Watanabe, T., Uematsu, Y., Sekine, K., Fukuda, T., Aihara, K., Krust, A., Yamada, T., Nakamichi, Y., Yamamoto, Y., Nakamura, T., Yoshimura, K., Yoshizawa, T., Metzger, D., Chambon, P. Kato, S. (2004) Brain masculinization requires androgen receptor function. Proc. Natl Acad. Sci. USA, 101, 1673 1678.
19. Scordalakes, E.M., Shetty, S.J. Rissman. E.F. (2002) Roles of estrogen receptor alpha and androgen receptor in the regulation of neuronal nitric oxide synthase. J. Comp. Neurol., 453, 336 344.
20. Service, G. Woodside, B. (2007) Inhibition of nitric oxide synthase within the medial preoptic area impairs pup retrieval in lactating rats. Behav. Neurosci., 121, 140 147.
21. Shoemaker, C.M., Queen, J. Crews, D. (2007) Response of candidate sex-determining genes to changes in temperature reveals their involvement in the molecular network underlying temperature-dependent sex determination. Mol. Endocrinol., 21, 2750 2763.
22. Singh, R., Pervin, S., Shryne, J., Gorski, R. Chaudhuri, G. (2000) Castration increases and androgens decrease nitric oxide synthase activity in the brain, physiologic implications. Proc. Natl Acad. Sci. USA, 97, 3672 3677.
23. Stenberg, D. (2007) Neuroanatomy and neurochemistry of sleep. Cell Mol. Life Sci., 64, 1187 1204.
24. Wade, J. Crews. D. (1991) The effects of intracranial implantation of estrogen on receptivity in sexually and asexually reproducing female whiptail lizards, Cnemidophorus inornatus and Cnemidophorus uniparens. Horm. Behav., 25, 342 253.
25. Wood, R.I. (1998) Integration of chemosensory and hormonal input in the male Syrian hamster brain. Ann. NY Acad. Sci., 855, 362 372.