Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library

BMC Biotechnology

Volumn 7, Issue , 2007, Pages

  Krumpe, Lauren R H ^a,b   Schumacher, Kathryn M ^a   McMahon, James B ^a   Makowski, Lee ^c   Mori, Toshiyuki ^a  

^a NCI Frederick   (United States)

^b SAIC FREDERICK INC   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOPHYSICS; DNA; PEPTIDES;

CODON; MORPHOGENESIS; TRINUCLEOTIDE CASSETTES;

OLIGONUCLEOTIDES;

PEPTIDE LIBRARY; TRINUCLEOTIDE; PEPTIDE; STREPTAVIDIN;

AMINO ACID SEQUENCE; ARTICLE; BACTERIOPHAGE T7; CODON; CONTROLLED STUDY; GENE CASSETTE; GENETIC VARIABILITY; NONHUMAN; PHAGE DISPLAY; RANDOMIZATION; VIRAL GENETICS; VIRUS MORPHOGENESIS; BACTERIOPHAGE M13; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; TRINUCLEOTIDE REPEAT;

AMINO ACID SEQUENCE; BACTERIOPHAGE M13; BACTERIOPHAGE T7; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PEPTIDE LIBRARY; PEPTIDES; STREPTAVIDIN; TRINUCLEOTIDE REPEATS; VARIATION (GENETICS);

EID: 37748999981     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-7-65     Document Type: Article

References (18)

1. Szardenings M Phage display of random peptide libraries: Applications, limits, and potential J Recept Signal Transduct Res 2003, 23:307-349. 10.1081/RRS-120026973 14753295
2. Krumpe LRH Mori T The Use of Phage-Displayed Peptide Libraries to Develop Tumor Targeting Drugs Int J Peptide Res Ther 2006, 12:79-91. 10.1007/s10989-005-9002-3
3. Ladner RC Sato AK Gorzelany J de Souza M Phage display-derived peptides as therapeutic alternatives to antibodies Drug Discov Today 2004, 9:525-529. 10.1016/S1359-6446(04)03104-6 15183160
4. Mori T Cancer-specific ligands identified from screening of peptide-display libraries Curr Pharm Des 2004, 10:2335-2343. 10.2174/ 1381612043383944 15279612
5. Krumpe LRH Mori T Potential of peptide library technology to identify functional targeting peptides Exp Opin Drug Discovery 2007, 2:525-537. 10.1517/17460441.2.4.525
6. Rodi DJ Soares AS Makowski L Quantitative assessment of peptide sequence diversity in M13 combinatorial peptide phage display libraries J Mol Biol 2002, 322:1039-1052. 10.1016/S0022-2836(02)00844-6 12367527
7. Rodi DJ Makowski L Phage-display technology-finding a needle in a vast molecular haystack Curr Opin Biotechnol 1999, 10:87-93. 10.1016/ S0958-1669(99)80016-0 10047512
8. Makowski L Soares A Estimating the diversity of peptide populations from limited sequence data Bioinformatics 2003, 19:483-489. 10.1093/ bioinformatics/btg013 12611803
9. Mandava S Makowski L Devarapalli S Uzubell J Rodi DJ RELIC-a bioinformatics server for combinatorial peptide analysis and identification of protein-ligand interaction sites Proteomics 2004, 4:1439-1460. 10.1002/pmic.200300680 15188413
10. Krumpe LRH Atkinson AJ Smythers GW Kandel A Schumacher KM McMahon JB Makowski L Mori T T7 Lytic Phage-Displayed Peptide Libraries Exhibit Less Sequence Bias than M13 Filamentous Phage-Displayed Peptide Libraries Proteomics 2006, 6:4210-4222. 10.1002/pmic.200500606 16819727
11. Sakamoto K Ito Y Mori T Sugimura K Interaction of human lactoferrin with cell adhesion molecules through RGD motif elucidated by lactoferrin-binding epitopes J Biol Chem 2006, 281(34):24472-24478. 10.1074/jbc.M604974200 16787913
12. Barbas CF III Burton DR Scott JK Silverman GJ Appendix 1, in Phage display: A laboratory manual Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York 2001 A1.1 A1.2
13. Kayushin AL Korosteleva MD Miroshnikov AI Kosch W Zubov D Piel N A convenient approach to the synthesis of trinucleotide phosphoramidites-synthons for the generation of oligonucleotide/peptide libraries Nucleic Acids Res 1996, 24:3748-3755. 146157 8871554 10.1093/ nar/24.19.3748
14. Virnekas B Ge L Pluckthun A Schneider KC Wellnhofer G Moroney SE Trinucleotide phosphoramidites: Ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis Nucleic Acids Res 1994, 22:5600-5607. 310122 7838712 10.1093/nar/22.25.5600
15. Kyte J Doolittle RF A simple method for displaying the hydropathic character of a protein J Mol Biol 1982, 157:105-132. 10.1016/ 0022-2836(82)90515-0 7108955
16. Chou PY Fasman GD Prediction of the secondary structure of proteins from their amino acid sequence Adv Enzymol Relat Areas Mol Biol 1978, 47:45-148. 364941
17. Rodi DJ Mandava S Makowski L DIVAA: Analysis of amino acid diversity in multiple aligned protein sequences Bioinformatics 2004, 20:3481-3489. 10.1093/bioinformatics/bth432 15284106
18. REceptor LIgand Contacts (RELIC) web server http://relic.bio.anl.gov/