A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution

Journal of Nuclear Medicine

Volumn 49, Issue 1, 2008, Pages 79-87

  Wu, Heyu ^a,b   Pal, Debashish ^c   O'Sullivan, Joseph A ^c   Tai, Yuan Chuan ^a,d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF MODERN PHYSICS   (China)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal imaging; High resolution PET; PET insert; Small animal PET

Indexed keywords

FLUORINE 18; GERMANIUM 68; LUTETIUM OXYORTHOSILICATE; RADIOPHARMACEUTICAL AGENT; SILICATE; SODIUM 22; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BONE SCINTISCANNING; CONTROLLED STUDY; FEASIBILITY STUDY; MEDICAL INSTRUMENTATION; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCINTILLATION CAMERA; SENSITIVITY ANALYSIS;

ANIMALS; BONE AND BONES; FEASIBILITY STUDIES; FLUORINE RADIOISOTOPES; MICE; PHANTOMS, IMAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY;

EID: 37649022872     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.044149     Document Type: Article

References (22)

1. Bloomfield PM, Rajeswaran S, Spinks TJ, et al. The design and physical characteristics of a small animal positron emission tomograph. Phys Med Biol. 1995;40:1105-1126.
2. 2 crystals and a photo sensitive wire chamber. Nucl Instrum Methods [A]. 06 1997;392(1-3):407-413.
3. Lecomte R, Cadorette J, Rodrigue S, et al. Initial results from the Sherbrooke avalanche photodiode positron tomograph. IEEE Trans Nucl Sci. 1996;43:1952-1957.
4. Cherry SR, Shao Y, Silverman RW, et al. MicroPET: a high resolution PET scanner for imaging small animals. IEEE Trans Nucl Sci. 1997;44:1161-1166.
5. Watanabe M, Okada H, Shimizu K, et al. A high resolution animal PET scanner using compact PS-PMT detectors. IEEE Trans Nucl Sci. 1997;44:1277-1282.
6. Del Guerra A, Di Domenico G, Scandola M, Zavattini G. YAP-PET: first results of a small animal positron emission tomograph based on YAP: Ce finger crystals. IEEE Trans Nucl Sci. 1998;45:3105-3108.
7. Jeavons AP, Chandler RA, Dettmar CAR. A 3D HIDAC-PET camera with submillimetre resolution for imaging small animals. IEEE Trans Nucl Sci. 1999;46:468-473.
8. Tai YC, Chatziioannou A, Yang Y, et al. MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging. Phys Med Biol. 2003;48:1519-1537.
9. Rouze NC, Schmand M, Siegel S, Hutchins GD. Design of a small animal PET imaging system with 1 microliter volume resolution. IEEE Trans Nucl Sci. 2004;51:757-763.
10. Vaska P, Woody CL, Schlyer DJ, et al. RatCAP: miniaturized head-mounted PET for conscious rodent brain imaging. IEEE Trans Nucl Sci. 2004;51:2718-2722.
11. Miyaoka RS, Janes ML, Lee K, Park B, Kinahan PE, Lewellen TK. Development of a prototype micro crystal element scanner (MiCES): QuickPET II. Mol Imaging. 2005;4:117-127.
12. Phelps ME. PET: the merging of biology and imaging into molecular imaging. J Nucl Med. 2000;41:661-681.
13. Weissleder R, Mahmood U. Molecular imaging. Radiology. 2001;219:316-333.
14. Tai Y-C, Wu H, Pal D, O'Sullivan JA. Virtual-pinhole positron emission tomography. J Nucl Med. In press.
15. Tai YC, Ruangma A, Rowland D, et al. Performance evaluation of the microPET-Focus: a third generation microPET scanner dedicated to animal imaging. J Nucl Med. 2005;46:455-463.
16. Pal D, O'Sullivan JA, Wu H, Janecek M, Tai Y-C. 2D linear and iterative reconstruction algorithms for a PET-insert scanner. Phys Med Biol. 2007;52:4293-4310.
17. Daube-Witherspoon ME, Muehllehner G. Treatment of axial data in three-dimensional PET. J Nucl Med. 1987;28:1717-1724.
18. Defrise M, Kinahan PE, Townsend DW, Michel C, Sibomana M, Newport DF. Exact and approximate rebinning algorithms for 3-D PET data. IEEE Trans Med Imaging. 1997;16:145-158.
19. Beekman FJ, van der Have F, Vastenhouw B, et al. U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice. J Nucl Med. 2005;46:1194-1200.
20. Funk T, Despres P, Barber WC, Shah KS, Hasegawa BH. A multipinhole small animal SPECT system with submillimeter spatial resolution. Med Phys. 2006;33:1259-1268.
21. Kim H, Furenlid LR, Crawford MJ, et al. SemiSPECT: a small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays. Med Phys. 2006;33:465-474.
22. Janecek M, Wu H, Tai YC. A simulation study for the design of a prototype insert for whole-body PET scanners. IEEE Trans Nucl Sci. 2006;53:1143-1149.