Synthesis of substituted benzimidazoles via tosylation of N-aryl amidoxime

Tetrahedron Letters

Volumn 49, Issue 5, 2008, Pages 876-878

  Yamamoto, Yuhei ^a   Tsuritani, Takayuki ^a   Mase, Toshiaki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Benzimidazoles; Imidoyl chlorides; N Aryl amidoximes; Nitrile oxides

Indexed keywords

2 CYCLOEHXYLBENZIMIDAZOLE DERIVATIVE; 2 PYRIDYLBENZIMIDAZOLE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; N ARYL AMIDOXIME; OXIME DERIVATIVE; PHENZIDOLE DERIVATIVE; TRIETHYLAMINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 37649018208     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.11.157     Document Type: Article

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37. Reactions were monitored by HPLC and intermediates are not isolated.
38. 6) δ 12.44 (br s, 0.75H), 12.08 (br s, 0.25H), 7.51 (d, J = 7.6 Hz, 1H), 7.47 (d, J = 7.0 Hz, 0.25H), 7.41 (d, J = 7.8 Hz, 0.75H) 6.92 (t, J = 7.8 Hz, 0.75H), 6.91 (t, J = 7.8 Hz, 0.25H), 2.81-2.94 (m, 1H), 1.93-2.04 (m, 2H), 1.75-1.86 (m, 2H), 1.52-1.75 (m, 3H), 1.24-1.50 (m, 3H).