Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 371-374

  Hosono, Tetsuji ^a   Yokomizo, Kazumi ^b   Hamasaki, Akiyuki ^c   Okamoto, Yoshinari ^c   Okawara, Tadashi ^d   Otsuka, Masami ^c   Mukai, Ryozaburo ^a   Suzuki, Keitarou ^a  

^a YOKOHAMA COLLEGE OF PHARMACY   (Japan)

^b SOJO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d KUMAMOTO HEALTH SCIENCE UNIVERSITY   (Japan)

Author keywords

Antiviral activity; Herpes simplex virus type 1; Histidine pyridine histidine; HPH; Structure activity relationship

Indexed keywords

ACICLOVIR; BLEOMYCIN; HISTIDINE DERIVATIVE; HISTIDINE PYRIDINE HISTIDINE 4; HISTIDINE PYRIDINE HISTIDINE 8; HISTIDINE PYRIDINE HISTIDINE DERIVATIVE; LIGAND; OXYGEN; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; HERPESVIRUS 1, HUMAN; HISTIDINE; HUMANS; MICE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

HUMAN HERPESVIRUS 1;

EID: 37549070730     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.065     Document Type: Article

References (17)

1. Corey L., and Spear P.G. N. Engl. J. Med. 13 (1986) 686
2. Jones C. Clin. Microbiol. Rev. 16 (2003) 79
3. Grover D., Newsholme W., Brink N., Manji H., and Miller R. Int. J. STD AIDS 15 (2004) 597
4. Whitley R.J. Antiviral Res. 71 (2006) 141
5. Coen D.M., and Schaffer P.A. Nat. Rev. Drug Disc. 2 (2003) 278
6. Otsuka M., Satake H., Murakami S., Doi M., Ishida T., Shibasaki M., and Sugiura Y. Bioorg. Med. Chem. 4 (1996) 1703
7. Villar K.D., Urano J., Guo L., and Tamanoi F. J. Biol. Chem. 274 (1999) 27010
8. Umezawa K., and Otsuka M. Gan To Kagaku Ryoho 24 (1997) 412
9. Suginaka R., Izui R., Inoue J., Muraoka Y., Yamaguchi K., Otsuka M., and Umezawa K. Jpn. J. Cancer Res. 89 (1998) 947
10. Umezawa K., Nakazawa K., Uchihata Y., and Otsuka M. Adv. Enzyme Regul. 39 (1999) 145
11. Bergeron R.J., Cavanaugh Jr. P.F., Kline S.J., Hughes Jr. R.G., Elliott G.T., and Porter C.W. Biochem. Biophys. Res. Commun. 121 (1984) 848
12. Tombeux J.J., Goeminne A.M., and Eeckhaut Z. J. Inorg. Nucl. Chem. 39 (1977) 1655
13. 6: C 59.35, H 4.98, N 15.05; found: C 59.33, H 4.75, N 15.04. HPH-7, see Matsumoto, M.; Okuno, Y.; Ogata, Y.; Kurosaki, H.; Okamoto, Y.; Otsuka, M. Heterocycles 2006, 69, 311.
14. 2: C 57.40, H 7.86, N 10.57; found: C 57.17, H 7.96, N 10.44.
15. 4: C 53.10, H 7.27, N 9.78; found: C 52.82, H 7.24, N 9.56.
16. 2 incubator, fixed with formalin, and stained with crystal violet in methanol at 3 days after infection. After washes with water and drying, the plaques were counted.
17. 4 cells per well. After 1 day, the cells were re-fed with 100 μL of DMEM containing 5% FCS and various concentrations of the target compounds. After 69-h incubation, 10 μL of Alamar blue reagent (Cosmo Bio Co., Ltd, Carlsbad, CA) was added to each culture, then the plates were reincubated for 4 h. The optical density of each culture at 570 nm was determined by spectrophotometer using a reference wavelength of 630 nm.