Analysis of gene expression in four parts of the red-deer antler using DNA chip microarray technology

Animal Biology

Volumn 58, Issue 1, 2008, Pages 67-90

  Gu, Lijuan ^a   Mo, Eunkyoung ^a   Zhu, Xuemei ^a   Jia, Xiaoqing ^a   Fang, Zheming ^a   Sun, Baishen ^a   Sung, Changkeun ^a  

^a Chungnam National University   (South Korea)

Author keywords

Antler base; Antler mid section; Antler tip; Antler upper section; Deer antler; DNA chip; Down regulated genes; Gene expression; Microarray; Up regulated genes

Indexed keywords

ARRAY; COMPARATIVE STUDY; DEER; DNA; GENE EXPRESSION; RARITY;

ANIMALIA; CERVIDAE; CERVUS ELAPHUS;

EID: 37549069113     PISSN: 15707555     EISSN: 15707563     Source Type: Journal    
DOI: 10.1163/157075608X303654     Document Type: Article

References (41)

1. Allen, S.P., Maden, M. & Price, J.S. (2002) A role for retinoic acid in regulating the regeneration of deer antlers. Dev. Biol., 251, 409-423.
2. Banks, W.J. & Newbrey, J.W. (1983) Light microscope study of the ossification process in developing antlers. In: D.B. Robert (Eds.), Antler Development in Cervidae, pp. 231-260.
3. Caesar Kleberg Wildlife Research Institute, Kingsville. Barling, P.M., Gupta, D.K. & Lim, C.E. (1999) Involvement of phosphodiesterase I in mineralization: Histochemical studies using antler from red deer (Cervus elaphus) as a model. Calcif. Tissue. Int., 65, 384-389.
4. Barling, P.M., Lai, A.K. & Nicholson, L.F. (2005) Distribution of EGF and its receptor in growing red deer antler. Cell. Biol. Int., 29, 229-236.
5. Barling, P.M., Liu, H., Matich, J., Mount, J., Ka Wai Lai, A., Ma, L. & Basford Nicholson, L.F. (2004) Expression of PTHrP and the PTH/PTHrP receptor in growing red deer antler. Cell. Biol. Int., 28, 661-673.
6. Bubenik, G.A. (2003) Deer Antler-A Wonder of Nature: Structure and Function of Antlers, Regulatuon of Their Development, and Their Potential in Medicine. In: J.S. Sim, H.H. Sunwoo, R.J. Hudson & B.T. Jeon (Eds.), Antler Science and Product Technology, pp. 3-13.
7. Edmonton, Canada. Chambers, J., Angulo, A., Amaratunga, D., Guo, H., Jiang, Y., Wan, J.S., Bittner, A., Frueh, K., Jackson, M.R., Peterson, P.A., Erlander, M.G. & Ghazal, P. (1999) DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression. J.Virol., 73, 5757-5766.
8. de Crombrugghe, B., Lefebvre, V. & Nakashima, K. (2001) Regulatory mechanisms in the pathways of cartilage and bone formation. Curr. Opin. Cell. Biol., 13, 721-727.
9. Elliott, J.L., Oldham, J.M., Ambler, G.R., Bass, J.J., Spencer, G.S., Hodgkinson, S.C., Breier, B.H., Gluckman, P.D. & Suttie, J.M. (1992) Presence of insulin-like growth factor-I receptors and absence of growth hormone receptors in the antler tip. Endocrinology, 130, 2513-2520.
10. Faucheux, C., Nesbitt, S.A., Horton, M.A. & Price, J.S. (2001) Cells in regenerating deer antler cartilage provide a microenvironment that supports osteoclast differentiation.J. Exp. Biol., 204, 443-455.
11. Feng, J.Q., Chen, D., Esparza, J., Harris, M.A., Mundy, G.R. & Harris, S.E. (1995) Deer antler tissue contains two types of bone morphogenetic protein 4 mRNA transcripts. Biochim. Biophys. Acta., 1263, 163-168.
12. Garcia, R.L., Sadighi, M., Francis, S.M., Suttie, J.M. & Fleming, J.S. (1997) Expression of neurotrophin-3 in the growing velvet antler of the red deer Cervus elaphus.J. Mol. Endocrinol., 19, 173-182.
13. Glenisson, P., Coessens, B., Vooren, S.V., Mathys, J., Moreau, Y., & Moor, B.D. (2004) TXTGate: profiling gene groups with text-based information. Genome. Biol., 5, R43.
14. Gyurjan, I., Molnar, A., Borsy, A., Steger, V., Hackler, L., Zomborszky, Z., Papp, P., Duda, E., Deak, F., Lakatos, P., Puskas, L.G. & Orosz, L. (2007) Gene expression dynamics in deer antler: mesenchymal differentiation toward chondrogenesis. Mol. Genet. Genomics, 277, 221-235.
15. Ha, Y.W., Jeon, B.T., Moon, S.H., Toyoda, H., Toida, T., Linhardt, R.J. & Kim, Y.S. (2005) Characterization of heparan sulfate from the unossified antler of Cervus elaphus. Carbohydr. Res., 340, 411-416.
16. Huang, G.S., Yang, S.M., Hong, M.Y., Yang, P.C. & Liu, Y.C. (2000) Differential gene expression of livers from ApoE deficient mice. Life. Sci., 68, 19-28.
17. Korpos, E., Molnar, A., Papp, P., Kiss, I., Orosz, L. & Deak, F. (2005) Expression pattern of matrilins and other extracellular matrix proteins characterize distinct stages of cell differentiation during antler development. Matrix. Biol., 24, 124-135.
18. Lau, K.H., Wu, L.W., Sheng, M.H., Amoui, M., Suhr, S.M. & Baylink, D.J. (2006) An osteoclastic protein-tyrosine phosphatase is a potential positive regulator of the c-Src protein-tyrosine kinase activity: a mediator of osteoclast activity.J. Cell. Biochem., 97, 940-955.
19. Li, C., Clark, D.E., Lord, E.A., Stanton, J.A. & Suttie, J.M. (2002) Sampling technique to discriminate the different tissue layers of growing antler tips for gene discovery. Anat. Rec., 268, 125-130.
20. Li, C. & Suttie, J.M. (2001) Deer antlerogenic periosteum: a piece of postnatally retained embryonic tissue? Anat. Embryol(Berl), 204, 375-388.
21. Marshal, L. (2000). Natural Remedies: Velvet antler under the microscope. Nutrition Science News.
22. Molnar, A., Gyurjan, I., Korpos, E., Borsy, A., Steger, V., Buzas, Z., Kiss, I., Zomborszky, Z., Papp, P., Deak, F. & Orosz, L. (2007) Identification of differentially expressed genes in the developing antler of red deer Cervus elaphus. Mol. Genet. Genomics, 277, 237-248.
23. Naski, M.C. & Ornitz, D.M. (1998) FGF signaling in skeletal development. Front. Biosci., 3, 781-794.
24. Newbrey, J.W. & Banks, W.J. (1983) Ultrastructural features of the cellular and matrical components of developing antler cartilage. In: D.B. Robert, (Eds.), Antler Development in Cervidae, pp. 261-272. Caesar Kleberg Wildlife Research Institute, Kingsville.
25. Nishida, N., Wakui, M., Tokunaga, K. & Suyama, A. (2001) Highly Specific and Quantitative Gene Expression Profiling Based on DNA Computing. Genome. Inform., 12, 259-260.
26. Price, J. & Allen, S. (2004) Exploring the mechanisms regulating regeneration of deer antlers. Philos. Trans. RSoc. Lond. B Biol. Sci., 359, 809-822.
27. Price, J.S., Allen, S., Faucheux, C., Althnaian, T. & Mount, J.G. (2005) Deer antlers: a zoological curiosity or the key to understanding organ regeneration in mammals?J. Anat., 207, 603-618.
28. Price, J.S., Oyajobi, B.O., Nalin, A.M., Frazer, A., Russell, R.G. & Sandell, L.J. (1996) Chondrogenesis in the regenerating antler tip in red deer: expression of collagen types I, IIA, IIB, and X demonstrated by in situ nucleic acid hybridization and immunocytochemistry. Dev. Dyn., 205, 332-347.
29. Sadighi, M. (1994) Effect of insulin-like growth factor-I(IGF-I)and IGF-II on the growth of antler cells in vitro. J. Endocrinal., 143, 461-469.
30. Sivanandam, A.S., Mohan, S., Kita, H., Kapur, S., Chen, S.T., Linkhart, T.A., Bagi, G., Baylink, D.J. & Qin, X. (2004) Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester. Biochem. J., 379, 57-64.
31. Sunwoo, H.H. & Sim, J.S. (2000) Potential uses of velvet antler as nutraceuticals, functional and medical foods in the West.J. Nutraceut. Function. Med. Foods., 2, 5-23.
32. Sunwoo, H.H., Sim, L.Y.M., Nakano, T., Hudson, R.J. & Sim, J.S. (1997) Glycosaminoglycans from growing antlers of wapiti (Cervus elaphus). Can. J. Anim. Sci., 77, 715-721.
33. Suttie, J.M., Fennessy, P.F., Corson, I.D., Laas, F.J., Crosbie, S.F., Butler, J.H. & Gluckman, P.D. (1989) Pulsatile growth hormone, insulin-like growth factors and antler development in red deer (Cervus elaphus scoticus) stags. J.Endocrinol., 121, 351-360.
34. Suttie, J.M., Fennessy, P.F., Corson, I.D., Veenvliet, B.A., Littlejohn, R.P. & Lapwood, K.R. (1992) Seasonal pattern of luteinizing hormone and testosterone pulsatile secretion in young adult red deer stags (Cervus elaphus) and its association with the antler cycle.J. Reprod. Fertil., 95, 925-933.
35. Suttie, J.M. & Haines, S.R. (2000) Clinical properties of deer velvet. Positive. Health, July, 32-38.
36. Tanaka, S., Takahashi, N., Udagawa, N., Sasaki, T., Fukui, Y., Kurokawa, T. & Suda, T. (1992) Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes. FEBS. Lett., 313, 85-89.
37. Tsunoda, S., Yamabe, H., Osawa, H., Kaizuka, M., Shirato, K. & Okumura, K. (2001) Cultured rat glomerular epithelial cells show gene expression and production of transforming growth factor-ß: expression is enhanced by thrombin. Nephrol. Dial. Transplant., 16, 1776-1782.
38. Tuckwell, C. (2003) Velvet antler - a summary of the literature on health benefits. A report for the Rural Industries Research and Development Corporation, Canberra, Australia.
39. Uchiyama, I., Miwa, T., Nishide, H., Suzuki, I., Omata, T. & Ikeuchi, M. (2000) Data submission system for cyanobacterial DNA chip consortium. Genome. Informatics, 11, 235-236.
40. Yang, S.H., Kim, J.S., Oh, T.J., Kim, M.S., Lee, S.W., Woo, S.K., Cho, H.S., Choi, Y.H., Kim, Y.H., Rha, S.Y., Chung, H.C. & An, S.W. (2003) Genome-scale analysis of resveratrol-induced gene expression profile in human ovarian cancer cells using a cDNA microarray. Int. J. Oncol., 22, 741-750.
41. Yang, Y.H., Dudoit, S., Luu, P., Lin, D.M., Peng, V., Ngai, J. & Speed, T.P. (2002) Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic. Acids. Res., 30, e15.