Ascorbic acid transported by sodium-dependent vitamin C transporter 2 stimulates steroidogenesis in human choriocarcinoma cells

Endocrinology

Volumn 149, Issue 1, 2008, Pages 73-83

  Wu, Ximei ^a   Iguchi, Takuma ^a   Itoh, Norio ^a   Okamoto, Kousuke ^a   Takagi, Tatsuya ^a,b   Tanaka, Keiichi ^a,c   Nakanishi, Tsuyoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA OHTANI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1; AROMATASE; ASCORBIC ACID; CARRIER PROTEIN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); ESTRADIOL; MESSENGER RNA; PROGESTERONE; RETROVIRUS VECTOR; SODIUM DEPENDENT VITAMIN C TRANSPORTER 2; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESTROGEN SYNTHESIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PLACENTA; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; RNA INTERFERENCE; STEROIDOGENESIS;

3-HYDROXYSTEROID DEHYDROGENASES; AROMATASE; ASCORBIC ACID; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CHORIOCARCINOMA; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, BIOLOGICAL; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PREGNANCY; PROGESTERONE; RNA, MESSENGER; RNA, SMALL INTERFERING; STEROIDS; SYMPORTERS; TUMOR CELLS, CULTURED; UTERINE NEOPLASMS;

EID: 37549066367     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0262     Document Type: Article

References (52)

1. Albrecht ED, Pepe GJ 1990 Placental steroid hormone biosynthesis in primate pregnancy. Endocr Rev 11:124-150
2. Payne AH, Hales DB 2004 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 25:947-970
3. Padh H 1991 Vitamin C: newer insights into its biochemical functions. Nutr Rev 49:65-70
4. Das PC, Das KP, Bagchi K, Dey CD 1993 Evaluation of tissue ascorbic acid status in different hormonal states of female rat. Life Sci 52:1493-1498
5. Eipper BA, Mains RE 1991 The role of ascorbate in the biosynthesis of neuroendocrine peptides. Am J Clin Nutr 54(6 Suppl):1153S-1156S
6. Grunewald RA 1993 Ascorbic acid in the brain. Brain Res Brain Res Rev 18:123-133
7. Roston S 1962 Ascorbic acid, oxygen, and the disappearance of adrenochrome and noradrenochrome. Nature 194:1079-1080
8. Levine M, Morita K 1985 Ascorbic acid in endocrine systems. Vitam Horm 42:1-64
9. Luck MR, Jeyaseelan I, Scholes RA 1995 Ascorbic acid and fertility. Biol Reprod 52:262-266
10. Luck MR, Jungclas B 1988 The time-course of oxytocin secretion from cultured bovine granulosa cells, stimulated by ascorbate and catecholamines. J Endocrinol 116:247-258
11. Luck MR 1990 Cholinergic stimulation, through muscarinic receptors, of oxytocin and progesterone secretion from bovine granulosa cells undergoing spontaneous luteinization in serum-free culture. Endocrinology 126:1256-1263
12. Tsuji M, Ito Y, Fukuda H, Terada N, Mori H 1989 Aromatase activity and progesterone metabolism in ovaries of scorbutic mutant rats unable to synthesize ascorbic acid. Int J Vitam Nutr Res 59:353-359
13. Rumsey SC, Kwon O, Xu GW, Burant CF, Simpson I, Levine M 1997 Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem 272:18982-18989
14. Illsley NP 2000 Glucose transporters in the human placenta. Placenta 21:14-22
15. Hahn T, Barth S, Hofmann W, Reich O, Lang I, Desoye G 1998 Hyperglycemia regulates the glucose-transport system of clonal choriocarcinoma cells in vitro. A potential molecular mechanism contributing to the adjunct effect of glucose in tumor therapy. Int J Cancer 78:353-360
16. Ogura K, Sakata M, Okamoto Y, Yasui Y, Tadokoro C, Yoshimoto Y, Yamaguchi M, Kurachi H, Maeda T, Murata Y 2000 8-Bromo-cyclic AMP stimulates glucose transporter-1 expression in a human choriocarcinoma cell line. J Endocrinol 164:171-178
17. Daruwala R, Song J, Koh WS, Rumsey SC, Levine M 1999 Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. FEBS Lett 460:480-484
18. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA 1999 A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature 399:70-75
19. Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD 1999 Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant. Biochim Biophys Acta 1461:1-9
20. Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD 1999 Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. Biochem Biophys Res Commun 262:762-768
21. Hediger MA 2002 New view at C. Nat Med 8:445-446
22. Biondi C, Pavan B, Dalpiaz A, Medici S, Lunghi L, Vesce F 2007 Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8/SVneo: effect of steroids, flavonoids and NSAIDs. Mol Hum Reprod 13:77-83
23. Prasad PD, Huang W, Wang H, Leibach FH, Ganapathy V 1998 Transport mechanisms for vitamin C in the JAR human placental choriocarcinoma cell line. Biochim Biophys Acta 1369:141-151
24. Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL 2002 Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med 8:514-517
25. Black S, Yu H, Lee J, Sachchithananthan M, Medcalf RL 2001 Physiologic concentrations of magnesium and placental apoptosis: prevention by antioxidants. Obstet Gynecol 98:319-324
26. Chappell LC, Seed PT, Kelly FJ, Briley A, Hunt BJ, Charnock-Jones DS, Mallet A, Poston L 2002 Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function. Am J Obstet Gynecol 187:777-784
27. Javert CT, Stander HJ 1943 Plasma vitamin C and prothrombin concentration in pregnancy and in threatened, spontaneous and habitual abortion. Surg Gynecol Obstet 420:114-120
28. Henmi H, Endo T, Kitajima Y, Manase K, Hata H, Kudo R 2003 Effects of ascorbic acid supplementation on serum progesterone levels in patients with a luteal phase defect. Fertil Steril 80:459-461
29. Ringler GE, Strauss 3rd JF 1990 In vitro systems for the study of human placental endocrine function. Endocr Rev 11:105-123
30. Takahashi T, Utoguchi N, Takara A, Yamamoto N, Nakanishi T, Tanaka K, Audus KL, Watanabe Y 2001 Carrier-mediated transport of folic acid in BeWo cell monolayers as a model of the human trophoblast. Placenta 22:863-869
31. Jones CR, Srinivas SR, Devoe LD, Ganapathy V, Prasad PD 2002 Inhibition of system A amino acid transport activity by ethanol in BeWo choriocarcinoma cells. Am J Obstet Gynecol 187:209-216
32. Sullivan MH 2004 Endocrine cell lines from the placenta. Mol Cell Endocrinol 228:103-119
33. Nakanishi T, Kohroki J, Suzuki S, Ishizaki J, Hiromori Y, Takasuga S, Itoh N, Watanabe Y, Utoguchi N, Tanaka K 2002 Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinoma cells. J Clin Endocrinol Metab 87:2830-2837
34. Nakanishi T, Nishikawa J, Hiromori Y, Yokoyama H, Koyanagi M, Takasuga S, Ishizaki J, Watanabe M, Isa S, Utoguchi N, Itoh N, Kohno Y, Nishihara T, Tanaka K 2005 Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. Mol Endocrinol 19:2502-2516
35. Nakanishi T, Hiromori Y, Yokoyama H, Koyanagi M, Itoh N, Nishikawa J, Tanaka K 2006 Organotin compounds enhance 17β-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta. Biochem Pharmacol 71:1349-1357
36. Wu X, Itoh N, Taniguchi T, Nakanishi T, Tanaka K 2003 Requirement of calcium and phosphate ions in expression of sodium-dependent vitamin C transporter 2 and osteopontin in MC3T3-E1 osteoblastic cells. Biochim Biophys Acta 1641:65-70
37. Wu X, Itoh N, Taniguchi T, Nakanishi T, Tatsu Y, Yumoto N, Tanaka K 2003 Zinc-induced sodium-dependent vitamin C transporter 2 expression: potent roles in osteoblast differentiation. Arch Biochem Biophys 420:114-120
38. Baayen RH, Feldman LB, Schreuder R 2006 Morphological influences on the recognition of monosyllabic monomorphemic words. J Mem Lang 55:290-313
39. Tuckey RC 2005 Progesterone synthesis by the human placenta. Placenta 26:273-281
40. Liang WJ, Johnson D, Jarvis SM 2001 Vitamin C transport systems of mammalian cells. Mol Membr Biol 18:87-95
41. Park S, Park CH, Hahm ER, Kim K, Kimler BF, Lee SJ, Park HK, Lee SH, Kim WS, Jung CW, Park K, Riordan HD, Lee JH 2005 Activation of Raf1 and the ERK pathway in response to l-ascorbic acid in acute myeloid leukemia cells. Cell Signal 17:111-119
42. Varadharaj S, Steinhour E, Hunter MG, Watkins T, Baran CP, Magalang U, Kuppusamy P, Zweier JL, Marsh CB, Natarajan V, Parinandi NL 2006 Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: regulation by MAP kinases. Cell Signal 18:1396-1407
43. Shimizu K 1970 Effects of ascorbic acid on the side-chain cleavage of cholesterol. Biochim Biophys Acta 210:333-340
44. Sulimovici S, Boyd GS 1968 The cholesterol side chain cleavage enzymes in immature rat ovary. Eur J Biochem 3:332-345
45. Ingermann RL, Stankova L, Bigley RH, Bissonnette JM 1988 Effect of monosaccharide on dehydroascorbic acid uptake by placental membrane vesicles. J Clin Endocrinol Metab 67:389-394
46. Rybakowski C, Mohar B, Wohlers S, Leichtweiss HP, Schroder H 1995 The transport of vitamin C in the isolated human near-term placenta. Eur J Obstet Gynecol Reprod Biol 62:107-114
47. Ingermann RL, Stankova L, Bigley RH 1986 Role of monosaccharide transporter in vitamin C uptake by placental membrane vesicles. Am J Physiol 250(4 Pt 1):C637-C641
48. Wu X, Iguchi T, Hirano J, Fujita I, Ueda H, Itoh N, Tanaka K, Nakanishi T 2007 Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes. Biochem Pharmacol 74:1020-1028
49. Yu R, Tan TH, Kong AN 1997 Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants. J Biol Chem 272:28962-28970
50. Ascoli M, Euffa J, Segaloff DL 1987 Epidermal growth factor activates steroid biosynthesis in cultured Leydig tumor cells without affecting the levels of cAMP and potentiates the activation of steroid biosynthesis by choriogonadotropin and cAMP. J Biol Chem 262:9196-9203
51. Xiao G, Cui Y, Ducy P, Karsenty G, Franceschi RT 1997 Ascorbic aciddependent activation of the osteocalcin promoter in MC3T3-E1 preosteoblasts: requirement for collagen matrix synthesis and the presence of an intact OSE2 sequence. Mol Endocrinol 11:1103-1113
52. Wu X, Itoh N, Taniguchi T, Hirano J, Nakanishi T, Tanaka K 2004 Stimulation of differentiation in sodium-dependent vitamin C transporter 2 overexpressing MC3T3-E1 osteoblasts. Biochem Biophys Res Commun 317:1159-1164