메뉴 건너뛰기




Volumn 42, Issue 11, 2007, Pages 1195-1200

Promoting mechanism of enhancers and transport pathway of large hydrophilic molecular across nasal epithelium studied by ESR and CLSM technologies

Author keywords

Absorption enhancer; Absorption promoting, mechanism; Confocal laser scanning microscopy; Electron spin resonance; Large hydrophilic molecular; Nasal epithelium; Transport pathway

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; CHITOSAN; GLYCYRRHIZIC ACID; HIRUDIN DERIVATIVE; HIRUDIN HV2; RECOMBINANT PROTEIN;

EID: 37549060388     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (2)

References (13)
  • 1
    • 0242288486 scopus 로고    scopus 로고
    • Absorption enhancers for nasal drug delivery [J]
    • Davis SS, Illum L. Absorption enhancers for nasal drug delivery [J]. Clin Pharmacokinet, 2003, 42: 1107-1128.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 1107-1128
    • Davis, S.S.1    Illum, L.2
  • 2
    • 85060770982 scopus 로고
    • Cardiology commentary and update: Hirudin [J]
    • Talley JD. Cardiology commentary and update: hirudin [J]. J Arkansas Med Soc , 1995,91:445-446.
    • (1995) J Arkansas Med Soc , vol.91 , pp. 445-446
    • Talley, J.D.1
  • 3
    • 33646455584 scopus 로고    scopus 로고
    • The pharmacokineties and pharmacodynamics of recombinant hirudin-2 nasal spray [J]
    • Zhang YJ, Zhang Q, Hou JL, et al. The pharmacokineties and pharmacodynamics of recombinant hirudin-2 nasal spray [J]. Acta Pharm Sin, 2006,41:268-271.
    • (2006) Acta Pharm Sin , vol.41 , pp. 268-271
    • Zhang, Y.J.1    Zhang, Q.2    Hou, J.L.3
  • 4
    • 27744602761 scopus 로고    scopus 로고
    • Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo [J]
    • Zhang YJ, Ma CH, Lu WL, et al. Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo [J]. Acta Pharmacol Sin, 2005,26:1402-1408.
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1402-1408
    • Zhang, Y.J.1    Ma, C.H.2    Lu, W.L.3
  • 5
    • 0026014122 scopus 로고
    • Nasal absorption in rats. II Effect of enhancers on insulin absorption and nasal histology [J]
    • Chandlerr SG, Ilium L, Tomas NM. Nasal absorption in rats. II Effect of enhancers on insulin absorption and nasal histology [J]. Int J Pharm, 1991,76:61-70.
    • (1991) Int J Pharm , vol.76 , pp. 61-70
    • Chandlerr, S.G.1    Ilium, L.2    Tomas, N.M.3
  • 6
    • 0021917823 scopus 로고
    • Assay of hirudin in plasma using a chromogenic thrombin substrate [J]
    • Griessbach U, Sturzebecber J, Markward TF. Assay of hirudin in plasma using a chromogenic thrombin substrate [J]. Thromb Res, 1985,37:347-350.
    • (1985) Thromb Res , vol.37 , pp. 347-350
    • Griessbach, U.1    Sturzebecber, J.2    Markward, T.F.3
  • 7
    • 0033123494 scopus 로고    scopus 로고
    • Early cardiac myocyte membrane changes in severely burned rats: A spin labding-esr study [J] . Chin
    • Tang HT, Chen YL, Shen HX, et al. Early cardiac myocyte membrane changes in severely burned rats: a spin labding-esr study [J] . Chin J Plast Surg Burns, 1999,15:224-227.
    • (1999) J Plast Surg Burns , vol.15 , pp. 224-227
    • Tang, H.T.1    Chen, Y.L.2    Shen, H.X.3
  • 8
    • 0037442918 scopus 로고    scopus 로고
    • Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function [J]
    • Hopkins AM, Walsh SV, Verkade P, et al. Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function [J]. J Cell Sci, 2003,15:725-742.
    • (2003) J Cell Sci , vol.15 , pp. 725-742
    • Hopkins, A.M.1    Walsh, S.V.2    Verkade, P.3
  • 9
    • 0032918606 scopus 로고    scopus 로고
    • The effect of methylated β-cyclodextrins on the tight junctions of the rat asal respiratory epithelium: Electron microscopic and confocal laser scanning microscopic visulization studies [J]
    • Marttine, Verhoef JC, Spies F, et al. The effect of methylated β-cyclodextrins on the tight junctions of the rat asal respiratory epithelium: electron microscopic and confocal laser scanning microscopic visulization studies [J]. J Control Release, 1999,57:205-213.
    • (1999) J Control Release , vol.57 , pp. 205-213
    • Marttine1    Verhoef, J.C.2    Spies, F.3
  • 10
    • 0027427996 scopus 로고
    • Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: Assessment of effect-reversibility and imaging of transepithelial transport route by confocal laser scanning microscopy [J]
    • Hurni MA, Noach ABJ, Blom-roosemalen MCM, et al. Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport route by confocal laser scanning microscopy [J]. J Pharm Exp Ther, 1993,267:942-950.
    • (1993) J Pharm Exp Ther , vol.267 , pp. 942-950
    • Hurni, M.A.1    Noach, A.B.J.2    Blom-roosemalen, M.C.M.3
  • 11
    • 0030787377 scopus 로고    scopus 로고
    • Chitosan as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement [J]
    • Schipper NG, Olsson S, Hoogstraate JA, et al. Chitosan as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement [J]. Pharm Res, 1997,14:923-929.
    • (1997) Pharm Res , vol.14 , pp. 923-929
    • Schipper, N.G.1    Olsson, S.2    Hoogstraate, J.A.3
  • 12
    • 0030947273 scopus 로고    scopus 로고
    • Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats: Effects of absorption enhancer [J]
    • Marttin E, Verhoef JC, Cullander C, et al. Confocal laser scanning microscopic visualization of the transport of dextrans after nasal administration to rats: effects of absorption enhancer [J]. Pharm Res, 1997,14:631-637.
    • (1997) Pharm Res , vol.14 , pp. 631-637
    • Marttin, E.1    Verhoef, J.C.2    Cullander, C.3
  • 13
    • 3242673511 scopus 로고    scopus 로고
    • Cyclodextrins in nasal delivery of low-molecular-weight heparins: In vivo and in vitro studies [J]
    • Yang T, Hussain A, Paulson J, et al. Cyclodextrins in nasal delivery of low-molecular-weight heparins: in vivo and in vitro studies [J]. Pharm Res, 2004,21:1127-1136.
    • (2004) Pharm Res , vol.21 , pp. 1127-1136
    • Yang, T.1    Hussain, A.2    Paulson, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.