The pharmacokinetics and pharmacodynamics of recombinant hirudin-2 nasal spray

Yaoxue Xuebao

Volumn 41, Issue 3, 2006, Pages 268-271

  Zhang, Yu Jie ^a   Zhang, Qiang ^b   Hou, Jun Ling ^a   Wang, Xiao Liang ^a   Chen, Ming Xia ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Anticoagulation; Nasal spary; Pharmacokinetics; Recombinant hirudin 2

Indexed keywords

HIRUDIN DERIVATIVE; HIRUDIN HV2; RECOMBINANT PROTEIN;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; DISSEMINATED INTRAVASCULAR CLOTTING; INTRANASAL DRUG ADMINISTRATION; MALE; PARTIAL THROMBOPLASTIN TIME; PATHOPHYSIOLOGY; RABBIT; RAT; SPRAGUE DAWLEY RAT; THROMBIN TIME;

ADMINISTRATION, INTRANASAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DISSEMINATED INTRAVASCULAR COAGULATION; HIRUDINS; MALE; PARTIAL THROMBOPLASTIN TIME; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; THROMBIN TIME;

EID: 33646455584     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Markwardt F. The development of hirudin as an antithrombotic drug [J]. Thromb Res, 1994,74:1-23.
2. Talley JD. Cardiology commentary and update: Hirudin [J]. J Arkansas Med Society, 1995,91:445-446.
3. Yan XY, Zhang XN, Zhang Q. Absorption of recombinant hirudin in rats GI tract [J]. Acta Pharm Sin, 2004,39:77-80.
4. Griebach U, Sturzebecher C, Markwardt F. Assay of hirudin in plasma using a chromogenic thrombin substrate [J]. Thromb Res, 1985,37:347-350.
5. Chandler SG, Illum L, Tomas NM. Nasal absorption in rats. II effect of enhancers on insulin absorption and nasal histology [J]. Int J Pharm, 1991,76:61-70.
6. Ishikawa A, Hafter R, Seemuller U, et al. The effect of hirudin on endotoxin induced disseminated intravascular coagulation (DIC) [J]. Thromb Res, 1980,19:351-358.
7. Groesch H, Damm D, Youssdl RB, et al. Comparison of two different methods for the determination of rDNA-hirudin in plasma samples: HPLC vs a chromogenic thrombin substrate [J]. Thromb Res, 1991,64:273-277.
8. Lu L, Wang CY, Han GZ, et al. Experimental studies on antithrombosis and preventing disseminated intravascular coagulation (DIC) of recombinant hirudin [J]. Chin Pharm J, 2002,37:707-709.
9. Li HY, Zhang FR, Wu LJ, et al. Pharmacokinetics of artenibenzoate in rats [J]. Acta Pharm Sin, 1995,30:422-427.
10. 125I-hiurdin in rats and dogs [J]. Folia Haematol (Leipz), 1988,115:s64-s69.
11. Raake W. Antithobotic action of recombinant hirudin in avenavenous thombosis model [J] Haemostssis, 1991,21:127-132.