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Volumn 23, Issue 12, 2007, Pages 1515-1520

Persistence of genotypic resistance to nelfinavir among women exposed to prophylactic antiretroviral therapy during pregnancy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; INDINAVIR; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; PROTEINASE; RNA DIRECTED DNA POLYMERASE; VIRUS RNA; ZIDOVUDINE;

EID: 37549057650     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2007.0025     Document Type: Article
Times cited : (12)

References (41)
  • 1
    • 0028003766 scopus 로고
    • Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group
    • Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, et al.: Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 1994;331:1173-1180.
    • (1994) N Engl J Med , vol.331 , pp. 1173-1180
    • Connor, E.M.1    Sperling, R.S.2    Gelber, R.3    Kiselev, P.4    Scott, G.5    O'Sullivan, M.J.6
  • 2
    • 0033523454 scopus 로고    scopus 로고
    • Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET012 randomized trial
    • Guay LA, Musoke P, Fleming T, Bagenda D, Allen M, Nakabitto C, et al.: Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET012 randomized trial. Lancet 1999;354:795-802.
    • (1999) Lancet , vol.354 , pp. 795-802
    • Guay, L.A.1    Musoke, P.2    Fleming, T.3    Bagenda, D.4    Allen, M.5    Nakabitto, C.6
  • 3
    • 0033528521 scopus 로고    scopus 로고
    • DITRAME Study Group. 6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Côte d'Ivoire and Burkina Faso: A double-blind placebo-controlled multicentre trial
    • Dabis F, Msellati P, Meda N, Welffens-Ekra C, You B, Manigart, et al.: DITRAME Study Group. 6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Côte d'Ivoire and Burkina Faso: A double-blind placebo-controlled multicentre trial. Lancet 1999;353:786-792.
    • (1999) Lancet , vol.353 , pp. 786-792
    • Dabis, F.1    Msellati, P.2    Meda, N.3    Welffens-Ekra, C.4    You, B.5    Manigart6
  • 4
    • 0033528520 scopus 로고    scopus 로고
    • Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: A randomized controlled trial
    • Shaffer N, Chuachoowong R, Mock PA, Bhadrakom C, Siriwasin W, Young NL, et al.: Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: A randomized controlled trial. Lancet 1999;353:773-780.
    • (1999) Lancet , vol.353 , pp. 773-780
    • Shaffer, N.1    Chuachoowong, R.2    Mock, P.A.3    Bhadrakom, C.4    Siriwasin, W.5    Young, N.L.6
  • 5
    • 0033528527 scopus 로고    scopus 로고
    • Short-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire: A randomized controlled trial
    • Whiktor SZ, Ekpini E, Karon JM, Nkengasong J, Maurice C, Severin AT, et al.: Short-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire: A randomized controlled trial. Lancet 1999;353:781-785.
    • (1999) Lancet , vol.353 , pp. 781-785
    • Whiktor, S.Z.1    Ekpini, E.2    Karon, J.M.3    Nkengasong, J.4    Maurice, C.5    Severin, A.T.6
  • 6
    • 0037055088 scopus 로고    scopus 로고
    • Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission
    • Dorenbaum A, Cunnigngham CK, Gelber RD, Culnane M, Mofenson L, Britto P, et al.: Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission. JAMA 2002;288:189-198.
    • (2002) JAMA , vol.288 , pp. 189-198
    • Dorenbaum, A.1    Cunnigngham, C.K.2    Gelber, R.D.3    Culnane, M.4    Mofenson, L.5    Britto, P.6
  • 7
    • 0037333802 scopus 로고    scopus 로고
    • A multicenter randomized controlled trial of nevirapine versus a combination of zidovudine and lamivudine to reduce intrapartum and early postpartum mother-to-child transmission of human immunodeficiency virus type 1
    • Moodley D, Moodley J, Coovadia H, Gray G, McIntrye J, Hofmer J, et al.: A multicenter randomized controlled trial of nevirapine versus a combination of zidovudine and lamivudine to reduce intrapartum and early postpartum mother-to-child transmission of human immunodeficiency virus type 1. J Infect Dis 2003;187:725-735.
    • (2003) J Infect Dis , vol.187 , pp. 725-735
    • Moodley, D.1    Moodley, J.2    Coovadia, H.3    Gray, G.4    McIntrye, J.5    Hofmer, J.6
  • 8
    • 15444365351 scopus 로고    scopus 로고
    • Field efficacy of zidovudine, lamivudine and single-dose nevirapine to prevent peripartum HIV transmission
    • ANRS 1201/1202 DITRAME PLUS Study Group
    • ANRS 1201/1202 DITRAME PLUS Study Group: Field efficacy of zidovudine, lamivudine and single-dose nevirapine to prevent peripartum HIV transmission. AIDS 2005;19:309-318.
    • (2005) AIDS , vol.19 , pp. 309-318
  • 9
    • 33745490244 scopus 로고    scopus 로고
    • Brasil: Programa Nacional de DST e Aids. Recomendações para a profilaxia da transmissão materno-infantil do HIV e terapia anti-retroviral em gestantes. Available at
    • Ministério da Saude, Secretaria de Vigilancia em Saude, Brasil: Programa Nacional de DST e Aids. Recomendações para a profilaxia da transmissão materno-infantil do HIV e terapia anti-retroviral em gestantes. Available at www.aids.gov.br.
    • Secretaria de Vigilancia em Saude
    • Ministério da Saude1
  • 10
    • 0343498466 scopus 로고    scopus 로고
    • Maternal viral load genotypic zidovudine resistance and infrequent failure of zidovudine therapy to prevent transmission of human immunodeficiency virus type 1 in Pediatric AIDS Clinical Trials Group Protocol 076
    • Eastman DE, Coombs RW, Frenkel LM, McSherry GD, Britto P, Herman SA, et al.: Maternal viral load genotypic zidovudine resistance and infrequent failure of zidovudine therapy to prevent transmission of human immunodeficiency virus type 1 in Pediatric AIDS Clinical Trials Group Protocol 076. J Infect Dis 1998;177:577-563.
    • (1998) J Infect Dis , vol.177 , pp. 577-563
    • Eastman, D.E.1    Coombs, R.W.2    Frenkel, L.M.3    McSherry, G.D.4    Britto, P.5    Herman, S.A.6
  • 11
    • 0033386254 scopus 로고    scopus 로고
    • Codon 215 mutations in human immunodeficiency virus-infected women
    • Kully C, Yerly S, Erb P, Kind C, Krautheim A, Perrin L, et al.: Codon 215 mutations in human immunodeficiency virus-infected women. J Infect Dis 1999;179:705-708.
    • (1999) J Infect Dis , vol.179 , pp. 705-708
    • Kully, C.1    Yerly, S.2    Erb, P.3    Kind, C.4    Krautheim, A.5    Perrin, L.6
  • 12
    • 0034105783 scopus 로고    scopus 로고
    • HIV-1 genotypic zidovudine drug resistance and the risk of maternal-infant transmission in the Women and Infants Transmission Study
    • Welles SJ, Pitt J, Colgrove R, McIntosh K, Chung PH, Colson A, et al.: HIV-1 genotypic zidovudine drug resistance and the risk of maternal-infant transmission in the Women and Infants Transmission Study. AIDS 2000;14:263-271.
    • (2000) AIDS , vol.14 , pp. 263-271
    • Welles, S.J.1    Pitt, J.2    Colgrove, R.3    McIntosh, K.4    Chung, P.H.5    Colson, A.6
  • 13
    • 0037040374 scopus 로고    scopus 로고
    • Changes in plasma HIV-1 RNA viral load and CD4 cell counts, and lack of zidovudine resistance among pregnant women receiving short-course zidovudine
    • Ekpini RA, Nkengsong JN, Sibailly T, Maurice C, Adjé C, Monga BB, et al.: Changes in plasma HIV-1 RNA viral load and CD4 cell counts, and lack of zidovudine resistance among pregnant women receiving short-course zidovudine. AIDS 2002;16:625-630.
    • (2002) AIDS , vol.16 , pp. 625-630
    • Ekpini, R.A.1    Nkengsong, J.N.2    Sibailly, T.3    Maurice, C.4    Adjé, C.5    Monga, B.B.6
  • 14
    • 0037321530 scopus 로고    scopus 로고
    • Effect of cessation of zidovudine prophylaxis to reduce vertical transmission on maternal HIV disease progression and survival
    • Bardeguez AD, Shapiro DE, Mofenson LM, Coombs R, Frenkel LM, Fowler MG, et al.: Effect of cessation of zidovudine prophylaxis to reduce vertical transmission on maternal HIV disease progression and survival. J Acquir Immune Defic Syndr 2003;32:170-181
    • (2003) J Acquir Immune Defic Syndr , vol.32 , pp. 170-181
    • Bardeguez, A.D.1    Shapiro, D.E.2    Mofenson, L.M.3    Coombs, R.4    Frenkel, L.M.5    Fowler, M.G.6
  • 15
    • 0242580964 scopus 로고    scopus 로고
    • Zidovudine resistance phenotype and risk of perinatal HIV-1 transmission of zidovudine monotherapy-treated women with moderately advanced disease
    • Bauer GR, Welles SL, Colgrove RR, and Pitt J: Zidovudine resistance phenotype and risk of perinatal HIV-1 transmission of zidovudine monotherapy-treated women with moderately advanced disease. J Acquir Immune Defic Syndr 2003;34:312-319.
    • (2003) J Acquir Immune Defic Syndr , vol.34 , pp. 312-319
    • Bauer, G.R.1    Welles, S.L.2    Colgrove, R.R.3    Pitt, J.4
  • 16
    • 12144286827 scopus 로고    scopus 로고
    • Drug resistance is uncommon in pregnant women with low viral load taking zidovudine monotherapy to prevent perinatal HIV transmission
    • Larbalestier N, Mullen J, O'Shea S, Cottam F, Sabin CA, Chrystie IL, et al.: Drug resistance is uncommon in pregnant women with low viral load taking zidovudine monotherapy to prevent perinatal HIV transmission. AIDS 2003;17:2667-2671.
    • (2003) AIDS , vol.17 , pp. 2667-2671
    • Larbalestier, N.1    Mullen, J.2    O'Shea, S.3    Cottam, F.4    Sabin, C.A.5    Chrystie, I.L.6
  • 17
    • 0032880154 scopus 로고    scopus 로고
    • Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy
    • Clarke JR, Braganza R, Mirza A, Stainsby S, Ait-Khaled M, Wright A, et al.: Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy. J Med Virol 1999;59:364-368.
    • (1999) J Med Virol , vol.59 , pp. 364-368
    • Clarke, J.R.1    Braganza, R.2    Mirza, A.3    Stainsby, S.4    Ait-Khaled, M.5    Wright, A.6
  • 18
    • 0035946701 scopus 로고    scopus 로고
    • Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1
    • Mandelbrot L, Mascaro AL, Rekacewicz C, Berrebi A, Bénifla JL, Burgard M, et al.: Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1. JAMA 2001;285:2083-2093.
    • (2001) JAMA , vol.285 , pp. 2083-2093
    • Mandelbrot, L.1    Mascaro, A.L.2    Rekacewicz, C.3    Berrebi, A.4    Bénifla, J.L.5    Burgard, M.6
  • 19
    • 0033816265 scopus 로고    scopus 로고
    • Identification of the K103N resistance mutation in Uganda women receiving nevirapine to prevent HIV-1 vertical transmission
    • Jackson JB, Becker-Pergola G, Guay LA, Musoke P, Mracna M, Fowler G, et al.: Identification of the K103N resistance mutation in Uganda women receiving nevirapine to prevent HIV-1 vertical transmission. AIDS 2000;14:F111-F115.
    • (2000) AIDS , vol.14
    • Jackson, J.B.1    Becker-Pergola, G.2    Guay, L.A.3    Musoke, P.4    Mracna, M.5    Fowler, G.6
  • 20
    • 0035913939 scopus 로고    scopus 로고
    • Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET012)
    • Eshleman SH, Mracna M, Guay LA, Deseyve M, Cunnigham S, Mirochnick M, et al.: Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET012). AIDS 2001;15:1951-1957.
    • (2001) AIDS , vol.15 , pp. 1951-1957
    • Eshleman, S.H.1    Mracna, M.2    Guay, L.A.3    Deseyve, M.4    Cunnigham, S.5    Mirochnick, M.6
  • 21
    • 0037099368 scopus 로고    scopus 로고
    • Development resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: A substudy of Pediactrics AIDS Clinical Trials Group Protocol 316
    • Cunningham CK, Chaix ML, Rekacewicz C, Britto P, Rouzioux C, Gelber RD, et al.: Development resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: A substudy of Pediactrics AIDS Clinical Trials Group Protocol 316. J Infect Dis 2002;186:181-188.
    • (2002) J Infect Dis , vol.186 , pp. 181-188
    • Cunningham, C.K.1    Chaix, M.L.2    Rekacewicz, C.3    Britto, P.4    Rouzioux, C.5    Gelber, R.D.6
  • 22
    • 3142762317 scopus 로고    scopus 로고
    • Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy
    • Jourdain G, Houng NNG, Le Couer S, Bowonwatanuwong C, Kantipong P, Leechanachai P, et al.: Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy. N Engl J Med 2004;335:229-240.
    • (2004) N Engl J Med , vol.335 , pp. 229-240
    • Jourdain, G.1    Houng, N.N.G.2    Le Couer, S.3    Bowonwatanuwong, C.4    Kantipong, P.5    Leechanachai, P.6
  • 23
    • 1642499255 scopus 로고    scopus 로고
    • Characterization of nevirapine resistance mutations in women with subtype A vs. D HIV-1 6-8 weeks after single-dose nevirapine (HIVNET012)
    • Eshleman SH, Guay L, Mwatha A, Brown ER, Cunningham SP, Musoke P, et al.: Characterization of nevirapine resistance mutations in women with subtype A vs. D HIV-1 6-8 weeks after single-dose nevirapine (HIVNET012). J Acquir Immune Defic Syndr 2004;35:126-130.
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 126-130
    • Eshleman, S.H.1    Guay, L.2    Mwatha, A.3    Brown, E.R.4    Cunningham, S.P.5    Musoke, P.6
  • 24
    • 20844453585 scopus 로고    scopus 로고
    • Nevirapine (NVP) resistance in women with HIV-1 subtype C compared with subtypes A and D, after the administration of single-dose NVP
    • Eshelman SH, Hoover DR, Chen S, Hudelson SE, Guay LA, Mwatha A, et al.: Nevirapine (NVP) resistance in women with HIV-1 subtype C compared with subtypes A and D, after the administration of single-dose NVP. J Infect Dis 2005;192:30-35.
    • (2005) J Infect Dis , vol.192 , pp. 30-35
    • Eshelman, S.H.1    Hoover, D.R.2    Chen, S.3    Hudelson, S.E.4    Guay, L.A.5    Mwatha, A.6
  • 25
    • 12144252054 scopus 로고    scopus 로고
    • Emergence of antiretroviral resistance in HIV-positive women receiving combination antiretroviral therapy in pregnancy
    • Lyons FE, Coughlan S, Byrne CM, Hopkins SM, Hall WW, and Mulcahy FM: Emergence of antiretroviral resistance in HIV-positive women receiving combination antiretroviral therapy in pregnancy. AIDS 2005;19:63-67.
    • (2005) AIDS , vol.19 , pp. 63-67
    • Lyons, F.E.1    Coughlan, S.2    Byrne, C.M.3    Hopkins, S.M.4    Hall, W.W.5    Mulcahy, F.M.6
  • 26
    • 29144452190 scopus 로고    scopus 로고
    • Antiretroviral resistance among HIV-positive pregnant women who have antiretroviral experience from previous pregnancy
    • Overton ET, Sungkanuparph S, Nurutdinova D, and Powderly WG: Antiretroviral resistance among HIV-positive pregnant women who have antiretroviral experience from previous pregnancy. AIDS 2005;19:1439-1442.
    • (2005) AIDS , vol.19 , pp. 1439-1442
    • Overton, E.T.1    Sungkanuparph, S.2    Nurutdinova, D.3    Powderly, W.G.4
  • 27
    • 37549062430 scopus 로고    scopus 로고
    • Post-partum interruption of a triple drug regimen containing nevirapine for prevention of mother-to-child transmission does not select the K103N mutation [abstract]
    • Denver, CO, February 5-8
    • Perez H, Vignoles M, Laufer N, Schvacha N, Dolcini G, Coll P, et al.: Post-partum interruption of a triple drug regimen containing nevirapine for prevention of mother-to-child transmission does not select the K103N mutation [abstract]. Proceedings of the 13th Conference on Retrovirus and Opportunistic Infections, Denver, CO, February 5-8, 2006.
    • (2006) Proceedings of the 13th Conference on Retrovirus and Opportunistic Infections
    • Perez, H.1    Vignoles, M.2    Laufer, N.3    Schvacha, N.4    Dolcini, G.5    Coll, P.6
  • 28
    • 0027122957 scopus 로고
    • Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention: 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 1992;41(RR17).
    • (1992) MMWR , vol.41 , Issue.RR17
  • 30
    • 3242810318 scopus 로고    scopus 로고
    • MEGA: Integrated software for molecular evolutionary genetics analysis and sequence alignment
    • Kumar S, Tamura K, and Nei M: MEGA: Integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 2004;5:150-163.
    • (2004) Brief Bioinform , vol.5 , pp. 150-163
    • Kumar, S.1    Tamura, K.2    Nei, M.3
  • 34
    • 0035865851 scopus 로고    scopus 로고
    • Human immunodeficiency virus type I protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PI) in PI-naïve patients
    • Perez EE, Rose SL, Peyser B, Lamers SL, Burkhardt B, Dunn BM, et al.: Human immunodeficiency virus type I protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PI) in PI-naïve patients. J Infect Dis 2001;183:579-588.
    • (2001) J Infect Dis , vol.183 , pp. 579-588
    • Perez, E.E.1    Rose, S.L.2    Peyser, B.3    Lamers, S.L.4    Burkhardt, B.5    Dunn, B.M.6
  • 35
    • 1042287077 scopus 로고    scopus 로고
    • Drug resistance in non-subtype B HIV-1
    • Kanto R, Katzenstein T. Drug resistance in non-subtype B HIV-1. J Clin Virol 2004;29:152-159.
    • (2004) J Clin Virol , vol.29 , pp. 152-159
    • Kanto, R.1    Katzenstein, T.2
  • 36
    • 33744548300 scopus 로고    scopus 로고
    • Natural polymorphism in protease and reverse transcriptase genes and in antiretroviral drug susceptibilities of non-B HIV-1 strains from treatment-naïve patients
    • Vergne L, Stuyver L, Van Houtte M, Butel C, Delaporte E, and Peeters M: Natural polymorphism in protease and reverse transcriptase genes and in antiretroviral drug susceptibilities of non-B HIV-1 strains from treatment-naïve patients. J Clin Virol 2006;36:43-49.
    • (2006) J Clin Virol , vol.36 , pp. 43-49
    • Vergne, L.1    Stuyver, L.2    Van Houtte, M.3    Butel, C.4    Delaporte, E.5    Peeters, M.6
  • 37
    • 0036720771 scopus 로고    scopus 로고
    • Prevalence of protease and reverse transcriptase drug resistance mutations over time in drug-naïve human immunodeficiency virus type 1-positive individuals in Rio de Janeiro, Brazil
    • Dumans AT, Soares MA, Pieniazek D, Kalish ML, Vroey V, Hertogs K, et al.: Prevalence of protease and reverse transcriptase drug resistance mutations over time in drug-naïve human immunodeficiency virus type 1-positive individuals in Rio de Janeiro, Brazil. Antimicrob Agents Chemother 2002;46:3075-3079.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3075-3079
    • Dumans, A.T.1    Soares, M.A.2    Pieniazek, D.3    Kalish, M.L.4    Vroey, V.5    Hertogs, K.6
  • 38
    • 3843132947 scopus 로고    scopus 로고
    • Primary HIV-1 drug resistance in Brazil
    • Soares MA, Brindeiro RM, and Tanuri A: Primary HIV-1 drug resistance in Brazil. AIDS 2004;18(Suppl. 3):S9-S13.
    • (2004) AIDS , vol.18 , Issue.SUPPL. 3
    • Soares, M.A.1    Brindeiro, R.M.2    Tanuri, A.3
  • 39
    • 0033385403 scopus 로고    scopus 로고
    • Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy
    • Devereux HL, Youle M, Johnson MA, and Loveday C: Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy. AIDS 1999;13:F123-F127.
    • (1999) AIDS , vol.13
    • Devereux, H.L.1    Youle, M.2    Johnson, M.A.3    Loveday, C.4
  • 40
    • 27744473506 scopus 로고    scopus 로고
    • Evolution of HIV resistance during treatment interruption in experienced patients and after restarting a new therapy
    • Balduin M, Sierra S, Daumer MP, Rockstroh JK, Oette M, Fatkenheuer G, et al.: Evolution of HIV resistance during treatment interruption in experienced patients and after restarting a new therapy. J Clin Virol 2005;34:277-287.
    • (2005) J Clin Virol , vol.34 , pp. 277-287
    • Balduin, M.1    Sierra, S.2    Daumer, M.P.3    Rockstroh, J.K.4    Oette, M.5    Fatkenheuer, G.6


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