Drug resistance is uncommon in pregnant women with low viral loads taking zidovudine monotherapy to prevent perinatal HIV transmission

AIDS

Volumn 17, Issue 18, 2003, Pages 2665-2667

  Larbalestier, Nick ^a   Mullen, Jane ^a   O'Shea, Siobhan ^a   Cottam, Fiona ^a   Sabin, Caroline A ^b   Chrystie, Ian L ^a   Welch, Jan ^c   Zuckerman, Mark ^c   Hay, Phillip ^d   Rice, Phillip ^d   Taylor, Graham P ^e   De Ruiter, Annemiek ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d ST GEORGE S HOSPITAL   (United Kingdom)

^e IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED DNA POLYMERASE; VIRUS RNA; ZIDOVUDINE;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; PERINATAL INFECTION; PREGNANCY; PRIORITY JOURNAL; UNITED KINGDOM; VIRUS LOAD; VIRUS MUTATION; VIRUS TRANSMISSION;

EID: 12144286827     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200312050-00015     Document Type: Article

References (5)

1. Lyall E, Blott M, de Ruiter A, et al. Guidelines for the management of HIV infection in pregnant women and the prevention of mother-to-child transmission. HIV Med 2001, 2:314-334.
2. Eastman PS, Shapiro DE, Coombs RW, et al. Maternal viral genotypic zidovudine resistance and infrequent failure of zidovudine therapy to prevent perinatal transmission of human immunodeficiency virus type 1 in Paediatric AIDS Clinical Trials Group Protocol 076. J Infect Dis 1998, 177:557-564.
3. Welles SL, Pitt J, Colgrove RC, McIntosh K, Hua Chung P, Colson A, et al. HIV-1 genotypic zidovudine drug resistance and the risk of maternal-infant transmission in the Women and Infant Transmission Study. AIDS 2000, 14:263-271.
4. Vandamme AM, Schmit J-C, VanDooren S, et al. Quantification of HIV-1 RNA in plasma: comparable results with the NASBA HIV-1 RNA QTand Amplicor HIV Monitor test. J Aqcuir Immune Defic Syndr 1996, 13:127-139.
5. Mellors JW, Munoz A, Giorgi JV, et al. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997, 126:946-954.