Leg ulcers associated with factor V Leiden and prothrombin G20210A and methyltetrahydrofolate reductase mutations: Successful treatment with warfarin

International Journal of Dermatology

Volumn 46, Issue 12, 2007, Pages 1319-1320

  Clivati Brandt, Hebert Roberto ^a   de Lorenzo Messina, Maria Cristina ^a   Belda Júnior, Walter ^a   Costa Martins, Jose Eduardo ^a   Criado, Paulo Ricardo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLATE REDUCTASE; 5 METHYLTETRAHYDROFOLIC ACID; BLOOD CLOTTING FACTOR 5 LEIDEN; CARDIOLIPIN ANTIBODY; PROTHROMBIN; UNCLASSIFIED DRUG; WARFARIN;

ADULT; ARTICLE; CASE REPORT; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; INTERNATIONAL NORMALIZED RATIO; LEG ULCER; PREVALENCE; RISK FACTOR; SKIN BIOPSY; THROMBOPHILIA; THROMBOPHLEBITIS;

ANTIBODIES, ANTICARDIOLIPIN; ANTICOAGULANTS; FACTOR V; FEMALE; HETEROZYGOTE; HUMANS; LEG ULCER; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION; PROTHROMBIN; THROMBOPHILIA; WARFARIN;

EID: 37549054652     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2007.03424.x     Document Type: Article

References (8)

1. Mekkes JR, Loots MAM, Van Der Wal AC, et al. Causes, investigation and treatment of leg ulceration. Br J Dermatol 2003; 148: 388-401.
2. Margolis DJ, Bilker W, Santanna J, et al. Venous leg ulcer: Incidence and prevalence in the elderly. J Am Acad Dermatol 2002; 46: 381-386.
3. Bradbury AW, MacKenzie RK, Burns P, et al. Thrombophilia and chronic venous ulceration. Eur J Vasc Endovasc Surg 2002; 24 (2): 97-104.
4. Mackenzie RK, Ludlam CA, Ruckley CV, et al. The prevalence of thrombophilia in patients with chronic venous leg ulceration. J Vasc Surg 2002; 35: 718-722.
5. Khan S, Dickerman JD. Hereditary thrombophilia. Thromb J 2006; 4: 15.
6. Macik BG, Rand JH, Konkle BA. Thrombophilia: What's a practitioner to do? Hematol Am Soc Hematol Educ Program 2001; 2001: 322-338.
7. Arruda VR, Annichino-Bizzacchi JM, Costa FF, et al. Factor V Leiden (FVQ 506) is common in a Brazilian population. Am J Hematol 1995; 49: 242-243.
8. Ribeaudeau F, Senet P, Cayuela JM, et al. A prospective coagulation study including resistance to activated protein C and mutations in factors V and II in venous leg ulcers. Br J Dermatol 1999; 141: 259-263.