Epinephrine 4 μg/mL added to a low-dose mixture of ropivacaine and fentanyl for lumbar epidural analgesia after total knee arthroplasty

Anesthesia and Analgesia

Volumn 106, Issue 1, 2008, Pages 301-304

  Förster, Johannes G ^a   Lumme, Hilkka M ^b   Palkama, Vilja J ^b   Rosenberg, Per H ^a   Pitkänen, Mikko T ^b  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b ORTON ORTHOPAEDIC HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CELECOXIB; DICLOFENAC; FENTANYL; OXYCODONE; PARACETAMOL; ROFECOXIB; ROPIVACAINE; AMIDE; LOCAL ANESTHETIC AGENT; NARCOTIC ANALGESIC AGENT;

ADD ON THERAPY; ADJUVANT THERAPY; AGED; ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EPIDURAL ANESTHESIA; FEMALE; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TOTAL KNEE REPLACEMENT; UNSPECIFIED SIDE EFFECT; DRUG COMBINATION; KNEE ARTHROPLASTY; LUMBAR VERTEBRA; MIDDLE AGED; TIME; TREATMENT OUTCOME;

AGED; AMIDES; ANALGESIA, EPIDURAL; ANALGESICS, OPIOID; ANESTHETICS, LOCAL; ARTHROPLASTY, REPLACEMENT, KNEE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; EPINEPHRINE; FEMALE; FENTANYL; HUMANS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OXYCODONE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TIME FACTORS; TREATMENT OUTCOME;

EID: 37549044269     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000287673.27439.19     Document Type: Article

References (18)

1. Niemi G, Breivik H. Adrenaline markedly improves thoracic epidural analgesia produced by a low-dose infusion of bupivacaine, fentanyl and adrenaline after major surgery. A randomised, double-blind, cross-over study with and without adrenaline. Acta Anaesthesiol Scand 1998;42:897-909
2. Niemi G, Breivik H. Epinephrine markedly improves thoracic epidural analgesia produced by a small-dose infusion of ropivacaine, fentanyl, and epinephrine after major thoracic or abdominal surgery: a randomized, double-blinded crossover study with and without epinephrine. Anesth Analg 2002;94:1598-605
3. Förster JG, Niemi TT, Aromaa U, Neuvonen PJ, Seppälä TA, Rosenberg PH. Epinephrine added to a lumbar epidural infusion of a small-dose ropivacaine-fentanyl mixture after arterial bypass surgery of the lower extremities. Acta Anaesthesiol Scand 2003;47:1106-13
4. Reddy SV, Maderdrut JL, Yaksh TL. Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J Pharmacol Exp Ther 1980;213:525-33
5. Collins JG, Kitahata LM, Matsumoto M, Homma E, Suzukawa M. Spinally administered epinephrine suppresses noxiously evoked activity of WDR neurons in the dorsal horn of the spinal cord. Anesthesiology 1984;60:269-75
6. Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Zbinden AM. Epidural epinephrine and clonidine: segmental analgesia and effects on different pain modalities. Anesthesiology 1997;87:785-94
7. Gogarten W, Van Aken H, Büttner J, Riess H, Wulf H, Bürkle H. Neuraxial blockade and thromboembolism prophylaxis/antithrombotic therapy: revised recommendations of the German Society of Anaesthesiology and Intensive Care. Anaesth Intensivmed 2003;44:218-30
8. Silvasti M, Pitkänen M. Patient-controlled epidural analgesia versus continuous epidural analgesia after total knee arthroplasty. Acta Anaesthesiol Scand 2001;45:471-6
9. Förster JG, Rosenberg PH. Small dose of clonidine mixed with low-dose ropivacaine and fentanyl for epidural analgesia after total knee arthroplasty. Br J Anaesth 2004;93:670-7
10. Baron CM, Kowalski SE, Greengrass R, Horan TA, Unruh HW, Baron CL. Epinephrine decreases postoperative requirements for continuous thoracic epidural fentanyl infusions. Anesth Analg 1996;82:760-5
11. Sakaguchi Y, Sakura S, Shinzawa M, Saito Y. Does adrenaline improve epidural bupivacaine and fentanyl analgesia after abdominal surgery? Anaesth Intensive Care 2000;28:522-6
12. Curatolo M. Is epinephrine unfairly neglected for postoperative epidural mixtures? Anesth Analg 2002;94:1381-3
13. Bernards CM, Shen DD, Sterling ES, Adkins JE, Risler L, Phillips B, Ummenhofer W. Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 2): effect of epinephrine. Anesthesiology 2003;99:466-75
14. Kozody R, Palahniuk RJ, Wade JG, Cumming MO, Pucci WR. The effect of subarachnoid epinephrine and phenylephrine on spinal cord blood flow. Can Anaesth Soc J 1984;31:503-8
15. Covino BG, Wildsmith JAW. Clinical Pharmacology of Local Anesthetic Agents. In: Cousins MJ, Bridenbaugh PO, eds. Neural Blockade in Clinical Anesthesia and Management of Pain. 3rd ed. Philadelphia: Lippincott-Raven Publishers, 1998:97-128
16. Millet L, Barbe P, Lafontan M, Berlan M, Galitzky J. Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose tissue. J Appl Physiol 1998;85:181-8
17. Cederholm I, Åkerman B, Evers H. Local analgesic and vascular effects of intradermal ropivacaine and bupivacaine in various concentrations with and without addition of adrenaline in man. Acta Anaesthesiol Scand 1994;38:322-7
18. Kristensen JD, Karlsten R, Gordh T. Spinal cord blood flow after intrathecal injection of ropivacaine and bupivacaine with or without epinephrine in rats. Acta Anaesthesiol Scand 1998;42:685-90