In vitro biocompatibility study of free and liposomaly-grafted copolymers bearing short blocks of aliphatic lipid-mimetic units. Cytotoxicity and hemolytic activity

Journal of Drug Delivery Science and Technology

Volumn 17, Issue 6, 2007, Pages 393-397

  Momekova, D ^a   Momekov, G ^a   Rangelov, S ^b   Lambov, N ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b INSTITUTE OF POLYMERS   (Bulgaria)

Author keywords

Biocompatibility; Cytotoxicity; Diblock copolymers; Hemolysis; Liposomes; PEG lipids

Indexed keywords

1,2 DISTEAROYL GLYCERO 3 PHOSPHOCHOLINE; 1,3 DIDODECYLOXY 2 GLYCIDYLGLYCEROL OXYETYLENIC 114; 1,3 DIDODECYLOXY 2 GLYCIDYLGLYCEROL OXYETYLENIC 115; 1,3 DODECYLOXYPROPANE 2 OL OXYETYLENIC 52; 1,3 DODECYLOXYPROPANE 2 OL OXYETYLENIC 92; ALIPHATIC COMPOUND; COPOLYMER; LIPID; LIPOSOME; MACROGOL 2000; PHOSPHORYLCHOLINE; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; DRUG STRUCTURE; ERYTHROCYTE MEMBRANE; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR WEIGHT; SURFACE PROPERTY;

EID: 37549028776     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(07)50079-1     Document Type: Article

References (20)

1. Torchilin V. P. - Recent advances with liposomes as pharmaceutical carriers. - Nat. Rev. Drug Discov., 4, 145-160, 2005.
2. Sharma G., Anabousi S., Ehrhardt C., Ravi Kumar M. N. - Liposomes as targeted drug delivery systems in the treatment of breast cancer. - J. Drug Target., 14, 301-310, 2006.
3. Simoes S., Filipe A., Faneca H., Mano M., Penacho N., Duzgunes N., De Lima M. P. - Cationic liposomes for gene delivery. - Expert Opin. Drug. Deliv., 2, 237-254, 2005.
4. Lasic D.D., Valiner J.J., Working P.K. - Sterically stabilized liposomes in cancer therapy and gene delivery. - Curr. Opin. Mol. Ther., 1, 177-185, 1999.
5. Woodle M. C. - Controlling liposome blood clearance by surface - grafted polymers. - Adv. Drug Deliv. Rev., 32, 139-152, 1998.
6. Woodle M.C., Lasic D.D. - Sterically stabilized liposomes. - Biochim. Biophys. Acta, 1113, 171-199, 1992.
7. Woodle M.C., Newman M.S., Cohen J.A. - Sterically stabilized liposomes: physical and biological properties. - J. Drug Target., 2, 397-403, 1994.
8. Roux E., Francis M., Winnik F.M., Leroux J.C. - Polymer based pH-sensitive carriers as a means to improve the cytoplasmic delivery of drugs. - Int. J. Pharm., 242, 25-36, 2002.
9. Roux E., Stomp R., Giasson S., Pezolet M., Moreau P., Leroux J.C. - Steric stabilization of liposomes by pH-responsive N-isopropylacrylamide copolymer. - J. Pharm. Sci., 91, 1795-1802, 2002.
10. Roux E., Passirani C., Scheffold S., Benoit J.P., Leroux J.C. - Serum-stable and long-circulating, PEGylated, pH-sensitive liposomes. - J. Control. Rel., 94, 447-451, 2004.
11. Romberg B., Metselaar J.M., Baranyi L., Snel C.J., Bunger R., Hennink W.E., Szebeni J., Storm G. - Poly(amino acid)s: promising enzymatically degradable stealth coatings for liposomes. - Int. J. Pharm., 331, 186-189, 2007.
12. Rangelov S., Almgren M., Tsvetanov C., Edwards K. - Synthesis, characterization and aggregation behavior of block copolymers bearing blocks of lipid-mimetic aliphatic double chain units. - Macromolecules, 35, 4770-4778, 2002.
13. Rangelov S., Edwards K., Almgren M., Karlsson G. - Steric stabilization of egg-phosphatidyl choline liposomes by copolymers bearing short blocks of lipid mimetic units. - Langmuir, 19, 172-181, 2003.
14. Momekova G., Rangelov S., Yanev S., Nikolova E., Konstantinov S., Romberg B., Storm G., Lambov N. - Long-circulating, pH-sensitive liposomes sterically stabilized by copolymers bearing short blocks of lipid - mimetic units. - Eur. J. of Pharm. Sci., 2007, doi:10.1016/j.ejpc.2007.08.009.
15. Mosmann T. - Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. - J Immunol. Methods, 65, 55-63, 1983.
16. Konstantinov S.M., Eibl H., Berger M.R. - BCR-ABL influences the antileukaemic efficacy of alkylphosphocholines. - Br. J. Haematol., 107, 365-380, 1999.
17. Martin F.J., Macdonald R.C. - Lipid vesicle-cell interactions. I. Hemagglutination and hemolysis. - J. Cell. Biol., 70, 494-505, 1976.
18. Agarwal A., Unfer R., Mallapragada S.K. - Investigation of in vitro biocompatibility of novel pentablock copolymers for gene delivery. - J. Biomed. Mater. Res. A, 81, 24-39, 2007.
19. Guan J., Wagner W.R. - Synthesis, characterization and cytocompatibility of polyurethaneurea elastomers with designed elastase sensitivity. - Biomacromolecules, 6, 2833-2842, 2005.
20. Zange R., Li Y., Kissel T. - Biocompatibility testing of ABA triblock copolymers consisting of poly(L-lactic-co-glycolic acid) A blocks attached to a central poly(ethylene oxide) B block under in vitro conditions using different L929 mouse fibroblasts cell culture models. - J. Control. Release, 56, 249-258, 1998.