Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers

Pharmacology Biochemistry and Behavior

Volumn 78, Issue 1, 2004, Pages 57-64

  Gutierrez, Sandra ^a   Ang Lee, Michael K ^a   Walker, Diana J ^a   Zacny, James P ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Benzodiazepine; Diazepam; Herb; Human; Mood; Psychomotor performance; Sedative hypnotic; Valerian; Valeriana officinalis

Indexed keywords

DIAZEPAM; HERBACEOUS AGENT; VALERIAN;

ADULT; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; HEALTH CARE POLICY; HUMAN; MOOD; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY;

ADULT; ANALYSIS OF VARIANCE; COGNITION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; PLANT EXTRACTS; PLANT PREPARATIONS; PSYCHOMOTOR PERFORMANCE; VALERIAN;

VALERIANA; VALERIANA OFFICINALIS;

EID: 2442639941     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2004.02.011     Document Type: Article

References (45)

1. American Psychiatric Association Diagnostic and statistical manual of mental disorders, fourth edition. 1994;American Psychiatric Association, Washington (DC)
2. Andreatini R., Sartori V.A., Seabra M.L.V., Leite J.R. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytother. Res. 16:2002;650-654
3. Baddeley A.D. A three-minute reasoning test based on grammatical transformation. Psychonom. Sci. 10:1968;341-342
4. Balderer G., Borbely A.A. Effect of valerian on human sleep. Psychopharmacology. 87:1985;406-409
5. Beaubrun G., Gray G.E. A review of herbal medicines for psychiatric disorders. Psychiatr. Serv. 5:2000;1130-1134
6. Cropley M., Cave Z., Ellis J., Middleton R.W. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions. Phytother. Res. 16:2002;23-27
7. Derogatis L.R. SCL-90-R: Symptom checklist-90-R: Administration, scoring & procedures manual. 3rd ed. 1994;National Computer Systems, Inc. Minneapolis
8. Derogatis L.R., Lipman R.S., Covi L.H. SCL-90: an outpatient psychiatric rating scale - a preliminary report. Psychopharmacol. Bull. 9:1973;13-17
9. Donath F., Quispe S., Diefenbach K., Maurer A., Fietze I., Roots I. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Pharmacopsychiatry. 33:2000;47-53
10. Dunaev V.V., Trzhetsinskii S.D., Tishkin V.S., Fursa N.S., Linenko V.I. Biological activity of the sum of the valepotriates isolated from Valeriana alliariifolia. Farmakol. Toksikol. 50:1987;33-37
11. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM IV Axis I Disorders - Clinician Version - SCID-I Administration Booklet. 1997;American Psychiatric Press, Washington (DC)
12. Fraser H.F., van Horn G.D., Martin W.R., Wolbach A.B., Isbell H. Methods for evaluating addiction liability. (a) "Attitude" of opiate addicts toward opiate-like drugs, (b) a short-term "direct" addiction test. J. Pharmacol. Exp. Ther. 133:1961;371-387
13. Fugh-Berman A., Cott J.M. Dietary supplements and natural products as psychotherapeutic agents. Psychosom. Med. 61:1999;712-728
14. Gerhard U., Linnenbrink N., Georghiadou C., Hobi V. Vigilance-decreasing effects of 2 plant-derived sedatives. Schweiz. Rundsch. Med. PRAXIS. 85:1996;473-481
15. Gessner B., Klasser M. Studies on the effect of Harmonicum much on sleep using polygraphic EEG recordings. EEG EMG Z. Elektroenzephalogr. Verwandte Geb. 15:1984;45-51
16. Glass J.R., Sproule B.A., Hermann N., Streiner D., Busto U.E. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J. Clin. Psychopharmacol. 23:2003;260-268
17. Haertzen C.A. Development of scales based on patterns of drug effects, using the Addiction Research Center Inventory (ARCI). Psychol Rep. 18:1966;163-194
18. Hamilton M. The assessment of anxiety states by rating. Br. J. Med. Psychol. 32:1959;50-55
19. Hendriks H., Bos R., Woerdenbag H., Koster A. Central nervous depressant activity of valerenic acid in the mouse. Planta Med. 1:1985;28-31
20. Kamm-Kohl A.V., Jansen W., Brockmann P. Moderne Baldriantherapie gegen vervose Storungen im Senium. Med. Welt. 35:1984;1450-1454
21. Kaye A.D., Clarke R.C., Sabar R., Vig S., Dhawan K.P., Hofbauer R., et al. Herbal medicines: current trends in anesthesiology practice - a hospital survey. J. Clin. Anesth. 12:2000;468-471
22. Kemper KJ. The Longwood Herbal Task Force and The Center for Holistic Pediatric Education and Research. Valerian (Valeriana officinalis), 1999. Available at: http://www.mcp.edu/herbal/default.htm. Accessed May 10, 2003.
23. Kohnen R., Oswald W.-D. The effects of valerian, propranolol, and their combination on activation, performance, and mood of healthy volunteers under social stress conditions. Pharmacopsychiatry. 21:1988;447-448
24. Kuhlmann J., Berger W., Podzuweit H., Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry. 32:1999;235-241
25. Leathwood P.D., Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Med. 51:1985;144-147
26. Leathwood P.D., Chauffard F. Quantifying the effects of mild sedatives. J. Psychiat. Res. 17:1982/1983;115-122
27. Leathwood P.D., Chauffard F., Heck E., Munoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol. Biochem. Behav. 17:1982;65-71
28. Leuschner J., Muller J., Rudmann M. Characterisation of the central nervous depressant activity of a commercially available valerian root extract. Arzneimittelforschung. 43:1993;638-641
29. Martin W.R., Sloan J.W., Sapira J.D., Jasinski D.R. Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin. Pharmacol. Ther. 12:1971;245-258
30. Matthews H.B., Lucier G.W., Fisher K.D. Medicinal herbs in the United States: research needs. Environ. Health Perspect. 107:1999;773-778
31. McCabe S. Complimentary herbal and alternative drugs in clinical practice. Perspect. Psychiatr. Care. 38:2002;98-107
32. Nuotto E.J., Korttila K.T. Evaluation of a new computerized psychomotor test battery: effects of alcohol. Pharmacol. Toxicol. 68:1991;360-365
33. 3H]GABA release. Neurochem. Res. 24:1999;1373-1378
34. PDR for Herbal Medicines. 2000;Medical Economics, Montvale (NJ)
35. Santos M.S., Ferreira F., Cunha A.P., Carvalho A.P., Ribeiro C.F., Macedo T. Synaptosomal GABA release as influenced by valerian root extract - involvement of the GABA carrier. Arch. Int. Pharmacodyn. 327:1994;220-231
36. Schulz H., Stolz C., Muller J. The effect of valerian extract on sleep polygraphy in poor sleepers: a pilot study. Pharmacopsychiatry. 27:1994;147-151
37. Schulz V., Hubner W.-D., Ploch M. Clinical trials with phyto-psychopharmacological agents. Phytomedicine. 4:1997;379-387
38. 1 adenosine receptors. J. Nat. Prod. 65:2002;1479-1485
39. Selzer M.L. The Michigan Alcoholism Screening Test: the quest for a new diagnostic instrument. Am. J. Psychiatry. 127:1971;89-94
40. Torrent M.T., Iglesias J., Adzet T. Experimental evaluation of the sedative action of tincture of valerian. Circ. Farm. 30:1972;107-112
41. Vorbach E.U., Gortelmeyer R., Bruning J. Therapie von Insomnien: Wirksamkeit und Vertraglichkeit eines Baldrian-Praparats. Psychopharmakotherapie. 3:1996;109-115
42. Wagner H., Jurcic K., Schaette R. Comparative studies on the sedative action of Valeriana extracts, valepotriates and their degradation products. Planta Med. 39:1980;358-365
43. Wechsler D. The Measurement and Appraisal of Adult Intelligence. 1958;Williams & Wilkins, Baltimore (MD)
44. Wetherell A. Performance tests. Environ. Health Perspect. 104(Suppl 2):1996;247-273
45. Yates K.M., O'Connery A., Horsley C.A. "Herbal ecstasy:" a case series of adverse reactions. N. Am. Med. J. 28:2000;315-317