Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 252-255

  Ali, Abdelselam ^a   Altamore, Timothy M ^a   Bliese, Marianne ^a   Fisara, Petr ^b   Liepa, Andris J ^a   Meyer, Adam G ^a   Nguyen, Oahn ^a   Sargent, Roger M ^b   Sawutz, David G ^c   Winkler, David A ^a   Winzenberg, Kevin N ^a   Ziebell, Angela ^a  

^a CSIRO   (Australia)

^b Schering Plough Pty Ltd   (Australia)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Ctenocephalides felis (cat flea); Haemonchus contortus; Oxime ether; Parasiticide; Rhipicephalus sanguineus (brown dog tick); Trifluoromethanesulfonanilide

Indexed keywords

ANILIDE; ANTIPARASITIC AGENT; FIPRONIL; IVERMECTIN; LEVAMISOLE; PERMETHRIN; TRIFLUOROMETHANESULFONANILIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CTENOCEPHALIDES; ECTOPARASITE; ENDOPARASITE; FLEA; HAEMONCHUS CONTORTUS; IN VITRO STUDY; INFECTION PREVENTION; NEMATODE; NONHUMAN; PARASITISM; RHIPICEPHALUS SANGUINEUS; STRUCTURE ACTIVITY RELATION; TICK;

ANIMALS; ANTIPARASITIC AGENTS; FLEAS; HAEMONCHUS; RHIPICEPHALUS SANGUINEUS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

CTENOCEPHALIDES FELIS; HAEMONCHUS CONTORTUS; RHIPICEPHALUS SANGUINEUS;

EID: 37549016405     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.090     Document Type: Article

References (13)

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7. 50 measurement protocols are described in Supplementary data.
8. 99 values were determined using the larval development assay described in Ref. 9.
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11. Representative procedures describing the preparation of 2-alkoxy- and 2-aryloxyiminoalkyl TFMS compounds, and O-alkyl-, O-benzyl-, and O-aryloxyamines are given in Supplementary data.
12. a) and lipophilicity (log P), see: Terada, H. Biochim. Biophys. Acta 1981, 639, 225.
13. The low C. felis mortality observed for compound 51 probably reflects measurement of mortality at 8 h rather than 24 h.