Expedient synthesis of rupatadine

Synthetic Communications

Volumn 38, Issue 1, 2008, Pages 122-127

  Agarwal, Rajendra ^a   Bhirud, Shekhar Bhaskar ^a   Bijukumar, Gopinathenpillai ^a   Khude, Gopal Dnyandev ^a  

^a Macleods Pharmaceuticals Ltd   (India)

Author keywords

5 methyl nicotonic acid; 5 methyl 3 chloromethyl pyridine hydrochloride; Rupatadine

Indexed keywords

ANTIHISTAMINIC AGENT; RUPATADINE; THROMBOCYTE ACTIVATING FACTOR;

ARTICLE; DRUG SYNTHESIS;

EID: 37549016033     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910701651276     Document Type: Article

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3. Unpublished results: HPLC analysis indicated 60.0% of monobromo compound. The dibromo compound and the unreacted 3,5-lutidine were in the range of ∼18-20%.
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