Putative tumor suppressor YueF affects the functions of hepatitis B virus X protein in hepatoma cell apoptosis and p53 expression

Biotechnology Letters

Volumn 30, Issue 2, 2008, Pages 235-242

  Huang, Jing ^a   Wu, Kailang ^a   Zhang, Jianlin ^a   Si, Wei ^a   Zhu, Ying ^a   Wu, Jianguo ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Apoptosis; Hepatitis B virus X protein; p53; Tumor suppressor; YueF

Indexed keywords

HEPATITIS B VIRUS X PROTEIN; HEPATOCARCINOGENESIS; TUMOR SUPPRESSOR;

GENE EXPRESSION; ONCOLOGY; TISSUE;

CELL DEATH;

HEPATITIS B VIRUS X PROTEIN; PROTEIN P53; TRANSACTIVATOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; YUEF PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL LINE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENE VECTOR; GENETICS; HUMAN; LIVER CELL; METABOLISM; PHYSIOLOGY; PLASMID; TUMOR CELL LINE;

APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; GENETIC VECTORS; HEPATOCYTES; HUMANS; PLASMIDS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

HEPATITIS B VIRUS;

EID: 37549006817     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-007-9531-2     Document Type: Article

References (16)

1. Cha C, Dematteo RP (2005) Molecular mechanisms in hepatocellular carcinoma development. Best Pract Res Clin Gastroenterol 19:25-37
2. Chirillo P, Pagano S, Natoli G (1997) The hepatitis B virus X gene induces p53-mediated programmed cell death. Proc Natl Acad Sci USA 94:8162-8167
3. Choi BH, Choi M, Jeon HY, Rho HM (2001) Hepatitis B viral X protein overcomes inhibition of E2F1 activity by pRb on the human Rb gene promoter. DNA Cell Biol 20:75-80
4. Chung TW, Lee YC, Ko JH, Kim CH (2003) Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. Cancer Res 63:3453-3458
5. Elmore LW, Hancock AR, Chang SF (1997) Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci USA 94:14707-14712
6. Kim KH, Seong BL (2003) Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of deathinducing signal. EMBO J 22:2104-2116
7. Lee SG, Rho HM (2000) Transcriptional repression of the human p53 gene by hepatitis B viral X protein. Oncogene 19:468-471
8. Murakami S (2001) Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol 36:651-660
9. Ogden SK, Lee KC, Barton C (2000) Hepatitis B viral transactivator HBx alleviates p53-mediated repression of alpha-fetoprotein gene expression. J Biol Chem 275:27806-27814
10. Parkin DM, Bray FI, Devesa SS (2001) Cancer burden in the year 2000. The global picture. Eur J Cancer 37:54-66
11. Su Q, Schroder CH, Otto G, Bannasch P (2000) Overexpression of p53 protein is not directly related to hepatitis B x protein expression and is associated with neoplastic progression in hepatocellular carcinomas rather than hepatic preneoplasia. Mutat Res 462:365-380
12. Tang H, Oishi N, Kaneko S, Murakami S (2006) Molecular functions and biological roles of hepatitis B virus x protein. Cancer Sci 97:977-983
13. Truant R, Antunovic J, Greenblatt J, Prives C, Cromlish JA (1995) Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. J Virol 69:1851-1859
14. Zhang JL, Si W, Zhao WG, Huang J, Wu JG (2005a) Preparation and Application of Antibody for Unknown Protein Interacting with HBx Protein. Wuhan University Journal (Natural Science Edition) 51:723-726
15. Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG (2005b) Human hepatitis B virus X protein inhibits cell apoptosis and promotes tumorgenesis through interacting with a serine protease Hepsin. Arch Virol 150:721-741
16. Zhang X, Wu KL, Yue X, Zhu Y, Wu JG (2007) Inhibition of SARS-CoV gene expression by adenovirus-delivered small hairpin RNA. Intervirology 50:63-70