Naltrexone reverses age-induced cognitive deficits in rats

Neurobiology of Aging

Volumn 29, Issue 2, 2008, Pages 309-313

  Rodefer, Joshua S ^a   Nguyen, Tuyet N ^a  

^a E11 SSH   (United States)

Author keywords

Attention; Cognition; Executive function; Frontal cortex; Learning; Naltrexone; Opioid

Indexed keywords

NALTREXONE; OPIATE ANTAGONIST;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; ATTENTION; BRAIN FUNCTION; COGNITIVE DEFECT; CONTROLLED STUDY; DISCRIMINATION LEARNING; FRONTAL CORTEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

AGING; ANALYSIS OF VARIANCE; ANIMALS; ATTENTION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 37549005095     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2006.10.005     Document Type: Article

References (15)

1. Barense M.D., Fox M.T., and Baxter M.G. Aged rats are impaired on an attentional set-shifting task sensitive to medial frontal cortex damage in young rats. Learn Mem 9 (2002) 191-201
2. Baxter M.G. Cognitive aging in nonhuman primates. In: Hof P.R., and Mobbs C.V. (Eds). Functional neurobiology of aging (2001), San Diego, Academic Press 407-419
3. Birrell J.M., and Brown V.J. Medial frontal cortex mediates perceptual attentional set shifting in the rat. J Neurosci 20 (2000) 4320-4324
4. Chang R.C., Rota C., and Glover R.E. A novel effect of an opioid receptor antagonist, naloxone, on the production of reactive oxygen species by microglia. Brain Res 854 (2000) 224-229
5. Chen K.C., Baxter M.G., and Rodefer J.S. Central blockade of muscarinic cholinergic receptors disrupts affective and attentional set-shifting. Eur J Neurosci 20 (2004) 1081-1088
6. Dias R., Robbins T.W., and Roberts A.C. Dissociation in prefrontal cortex of affective and attentional shifts. Nature 380 (1996) 69-72
7. Gallagher M., Bostock E., and King R. Effects of opiate antagonists on spatial memory in young and old rats. Behav Neural Biol 44 (1985) 374-385
8. Katzen-Perez K.R., Jacobs D.W., Lincoln A., and Ellis R.J. Opioid blockade improves human recognition memory following physiological arousal. Pharm Biochem Behav 70 (2001) 77-84
9. Margolis E.B., Lock H., Chefer V.I., Shippenberg T.S., Hjelmstad G.O., and Fields H.L. κ opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. PNAS 103 (2006) 2938-2942
10. Mizuno T., and Kimura F. Medial septal injection of NAL elevates acetylcholine release in the hippocampus and induces behavioral seizures in rats. Brain Res 713 (1996) 1-7
11. Nicolle M.M., and Baxter M.G. Glutamate receptor binding in the frontal cortex and dorsal straitum of aged rats with impaired attentional set-shifting. Eur J Neurosci 18 (2003) 3335-3342
12. Owen A.M., Roberts A.C., Polkey C.E., Sahakian B.J., and Robbins T.W. Extra-dimensional versus intradimensional set-shifting performance following frontal lobe excisions, temporal lobe excisions or amydgalo-hippocampectomy in man. Neurpsychologica 29 (1991) 993-1006
13. Reisberg B., Ferris S.H., Anand R., Mir P., Geibel V., and de Leon M.J. Effects of naloxone in senile dementia: a double-blind trial. N Engl J Med 308 (1983) 721-722
14. Trippodi-Murphy C & Kogan JH. Attentional set shifting in young and aged Sprague Dawley rats. Prog No. 199.9. 2005 Abstract Viewer/Itinerary Planner. Society for Neuroscience, Washington, DC, Online.
15. Zhao H., Xu H., and Xu X. Effects of naloxone on the long-term potentiation of EPSPs from the pathway of Schaffer collateral to CA1 region of hippocampus in aged rats with declined memory. Brain Res 996 (2002) 111-116