Advances in study of novel absorption enhancers based on tight junctions

Yaoxue Xuebao

Volumn 42, Issue 11, 2007, Pages 1122-1128

  Kang, An ^a   Liang, Yan ^a   Hao, Hai Ping ^a   Xie, Lin ^a   Wang, Guang Ji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Absorption enhancer; Paracellular pathway; Tight junction

Indexed keywords

CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; CHOLERA TOXIN; CLAUDIN 1; DECANOIC ACID; DECANOIC ACID DERIVATIVE; ENTEROTOXIN; ENTEROTOXIN, CLOSTRIDIUM; F11R PROTEIN, HUMAN; MEMBRANE PROTEIN; NITRIC OXIDE DONOR; OCCLUDIN; PHOSPHOPROTEIN; ZONULA OCCLUDENS 1 PROTEIN; ZONULA OCCLUDENS TOXIN, VIBRIO CHOLERAE; ZONULA OCCLUDENS-1 PROTEIN;

ANIMAL; BIOAVAILABILITY; CYTOSKELETON; DRUG DELIVERY SYSTEM; DRUG EFFECT; HUMAN; INTESTINE ABSORPTION; METABOLISM; PHYSIOLOGY; REVIEW; TIGHT JUNCTION;

ANIMALS; BIOLOGICAL AVAILABILITY; CELL ADHESION MOLECULES; CHOLERA TOXIN; CYTOSKELETON; DECANOIC ACIDS; DRUG DELIVERY SYSTEMS; ENTEROTOXINS; HUMANS; INTESTINAL ABSORPTION; MEMBRANE PROTEINS; NITRIC OXIDE DONORS; PHOSPHOPROTEINS; RECEPTORS, CELL SURFACE; TIGHT JUNCTIONS;

EID: 37549002534     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (35)

1. Salama NN, Eddington ND, Fasano A. Tight junction modulation and its relationship to drug delivery [J]. Adv Drug Deliv Rev, 2006, 58:15-28.
2. Han M, Han LM, Wang QS, et al. Mechanism of oral absorption of panaxnotoginseng saponins [J]. Acta Pharm Sin, 2006, 41:498-505.
3. Nagahara N, Tavelin S, Artursson P. Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs [J]. J Pharm Sci, 2004, 93:2972-2984.
4. Feldman GJ, Mullin JM, Ryan MP. Occludin: structure, function and regulation [J]. Adv Drug Deliv Rev, 2005, 57:883-917.
5. Schulzke JD, Gitter AH, Mankertz J, et al. Epithelial transport and barrier function in occludin-deficient mice [J]. Biochim Biophys Acta, 2005, 1669:34-42.
6. Morita K, Furuse M, Fujimoto K, et al. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands [J]. Proc Natl Acad Sci, 1999, 96:511-516.
7. Colegio OR, Van Itallie CM, Mccrea HJ, et al. Claudins create charge-selective channels in the paracellular pathway between epithelial cells [J]. Am J Physiol Cell Physiol, 2002, 283:142-147.
8. Furuse M, Hata M, Furuse K. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1 - deficient mice [J]. J Cell Biol, 2002, 156:1099-1111.
9. Müller SL, Portwich M, Schmidt A, et al. The tight junction protein occludin and the adherens junction protein α-catenin share a common interaction mechanism with ZO-1 [J]. J Biol Chem, 2005, 280:3747-3756.
10. Utepbergenov DI, Fanning AS, Anderson JM, et al. Dimerization of the scaffolding protein ZO-1 through the second PDZ domain [J]. J Biol Chem, 2006, 281:24671-24677.
11. Cordenonsi M, D' Atri F, Hammar E, et al. Cingulin contains globular and coiled-coil domains and interacts with ZO-1 , ZO-2, ZO-3, and myosin [J]. J Cell Biol, 1999, 147:1569-1581.
12. Shen L, Black ED, Witkowski ED, et al. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure [J]. J Cell Sci, 2006, 119:2095-2106.
13. Benais-Pont G, Punn A, Flores-Maldonado C, et al, Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability [J]. J Cell Biol, 2003, 160:729-740.
14. Fleegal MA, Hom S, Borg LK, et al. Activation of PKC modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation [J]. Am J Physiol Heart Cire Physiol, 2005, 289:H2012-H2019.
15. Farhadi A, Banan A, Fields J, et al. Intestinal barrier: an interface between health and disease [J]. J Gastroenterol Hepatal, 2003, 18:479-497.
16. Li YH, Zhang M, Wang JC, et al. Effects of absorption enhancers on intestinal absorption of lumbrokinase [J]. Acta Pharm Sin, 2006, 41:939-944.
17. Lindmark T, Kimura Y, Artursson P. Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells [J]. J Pharmacol Exp Ther, 1998, 284:362-369.
18. Sha XY, Fang XL. Effect of self-microemulsifying system on cell tight junctions [J]. Acta Pharm Sin, 2006, 41:30-35.
19. Yamamoto A, Tatsumi H, Maruyama M. Modulation of intestinal permeability by nitric oxide donors: implications in intestinal delivery of poorly absorbable drugs [J]. J Pharmacol Exp Ther, 2001, 296:84-90.
20. Motlekar NA, Srivenugopal KS, Wachtel MS. Modulation of gastrointestinal permeability of low-molecular-weight-heparin by i-arginine: in vivo and in vitro evaluation [J]. J Pharm Pharmacol, 2006, 58:591-598.
21. Tavelin S, Hashimoto K, Malkinson J, et al. A new principle for tight junction modulation based on occludin peptides [J]. Mol Pharmacol, 2003, 64:1530-1540.
22. Everett RS, Vanhook MK, Barozzi N, et al. Specific modulation of airway epithelial tight junctions by apical application of an occludin peptide [J]. Mol Pharmacol, 2006, 69:492-500.
23. Kondoh M, Masuyama A, Takahashi A, et al. A novel strategy for the enhancement of drug absorption using a claudin modulator [J]. Mol Pharmacol, 2005, 67:749-756.
24. Masuyama A, Kondoh M, Seguchi H, et al. Role of N-terminal amino acids in the absorption-enhancing effects of the C-terminal fragment of Clostridium perfringens enterotoxin [J]. J Pharmacol Exp Ther, 2005, 314: 789-795.
25. Kondoh M, Takahashi A, Fujii M, et al. A novel strategy for a drug delivery system using a claudin modulator [J]. Biol Pharm Bull, 2006,29:1783-1789.
26. Sonoda N, Furuse M, Sasaki H, et al. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands; evidence for direct involvement of claudins in tight junction barrier [J]. J Cell Biol, 1999, 147:195-204.
27. Salama NN, Fasano A, Thakar M. The impact of Δ G on the oral bioavailability of low bioavailable therapeutic agents [J]. J Pharmacol Exp Ther, 2005, 312:199-205.
28. Karyekar CS, Fasano A, Raje S, et al. Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells [J]. J Pharm Sci, 2003, 92:414-423.
29. Marinaro M, Fasano A. Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses [J]. Infect Immun, 2003, 71:1897-1902.
30. Fasano A. Intestinal zonulin; open sesame [J]. Gut, 2001, 49:159-162.
31. Menez C, Buyse M, Chacun H, et al. Modulation of intestinal barrier properties by miltefosine [J]. Biochem Pharmacol, 2006, 71:486-496.
32. Motlekar NA, Srivenugopal KS, Wachtel MS, et al. Evaluation of the oral bioavailability of low molecular weight heparin formulated with glycyrrhetinic acid as permeation enhancer [J]. Drug Develop Res, 2006, 67:166-174.
33. Konishi Y. Modulation of food-derived substances on intestinal permeability in Caco-2 cell monolayers [J]. Biosci Biotechnol Biochem, 2003, 67:2297-2299.
34. Komori Y, Aiba T, Sugiyama R, et al. Effects of capsaicin on intestinal cephalexin absorption in rats [J]. Biol Pharm Bull, 2007, 30:547-551.
35. Nagumo Y, Han J, Arimoto M, et al. Capsaicin induces cofilin dephosphorylation in human intestinal cells: the triggering role of cofilin in tight-junction signaling [J]. Biochem Biophys Res Commun, 2007, 355:520-525.