메뉴 건너뛰기




Volumn 220, Issue 1-3, 2007, Pages 87-95

Amino acids that confer transport of raffinose and maltose sugars in the raffinose permease (RafB) of Escherichia coli as implicated by spontaneous mutations at Val-35, Ser-138, Ser-139, Gly-389 and Ile-391

Author keywords

Amino acid; Bacteria; Maltose; Mutation; Permease; Raffinose; Secondary active transport; Sugar; Symport

Indexed keywords

AMINO ACID; MALTOSE; PERMEASE; RAFFINOSE; RAFFINOSE PERMEASE; UNCLASSIFIED DRUG;

EID: 37449002533     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-007-9077-1     Document Type: Article
Times cited : (5)

References (58)
  • 1
    • 0041353145 scopus 로고    scopus 로고
    • Structure and mechanism of the lactose permease of Escherichia coli
    • Abramson J, Smirnova I, et al. (2003) Structure and mechanism of the lactose permease of Escherichia coli. Science 301:610-615
    • (2003) Science , vol.301 , pp. 610-615
    • Abramson, J.1    Smirnova, I.2
  • 2
    • 4444328639 scopus 로고    scopus 로고
    • Lactose permease as a paradigm for membrane transport proteins
    • Abramson J, Iwata S, et al. (2004a) Lactose permease as a paradigm for membrane transport proteins. Mol Membr Biol 21:227-236
    • (2004) Mol Membr Biol , vol.21 , pp. 227-236
    • Abramson, J.1    Iwata, S.2
  • 3
    • 4143061717 scopus 로고    scopus 로고
    • Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: Members of the major facilitator superfamily
    • Abramson J, Kaback HR, et al. (2004b) Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. Curr Opin Struct Biol 14:413-419
    • (2004) Curr Opin Struct Biol , vol.14 , pp. 413-419
    • Abramson, J.1    Kaback, H.R.2
  • 4
    • 0024316778 scopus 로고
    • Nucleotide sequences and operon structure of plasmid-borne genes mediating uptake and utilization of raffinose in Escherichia coli
    • Aslanidis C, Schmid K, et al. (1989) Nucleotide sequences and operon structure of plasmid-borne genes mediating uptake and utilization of raffinose in Escherichia coli. J Bacteriol 171:6753-6763
    • (1989) J Bacteriol , vol.171 , pp. 6753-6763
    • Aslanidis, C.1    Schmid, K.2
  • 5
    • 0026444105 scopus 로고
    • Characterization of a chromosomally encoded, non-PTS metabolic pathway for sucrose utilization in Escherichia coli EC3132
    • Bockmann J, Heuel H, et al. (1992) Characterization of a chromosomally encoded, non-PTS metabolic pathway for sucrose utilization in Escherichia coli EC3132. Mol Gen Genet 235:22-32
    • (1992) Mol Gen Genet , vol.235 , pp. 22-32
    • Bockmann, J.1    Heuel, H.2
  • 6
    • 0031887807 scopus 로고    scopus 로고
    • Maltose/maltodextrin system of Escherichia coli: Transport, metabolism, and regulation
    • Boos W, Shuman H (1998) Maltose/maltodextrin system of Escherichia coli: transport, metabolism, and regulation. Microbiol Mol Biol Rev 62:204-229
    • (1998) Microbiol Mol Biol Rev , vol.62 , pp. 204-229
    • Boos, W.1    Shuman, H.2
  • 7
    • 0025260988 scopus 로고
    • Characterization of the double mutant, Val-177/Asn-322, of the lactose permease
    • Brooker RJ (1990) Characterization of the double mutant, Val-177/Asn-322, of the lactose permease. J Biol Chem 265:4155-4160
    • (1990) J Biol Chem , vol.265 , pp. 4155-4160
    • Brooker, R.J.1
  • 8
    • 0025831225 scopus 로고
    • An analysis of lactose permease "sugar specificity" mutations which also affect the coupling between proton and lactose transport. I. Val177 and Val177/Asn319 permeases facilitate proton uniport and sugar uniport
    • Brooker RJ (1991) An analysis of lactose permease "sugar specificity" mutations which also affect the coupling between proton and lactose transport. I. Val177 and Val177/Asn319 permeases facilitate proton uniport and sugar uniport. J Biol Chem 266:4131-4138
    • (1991) J Biol Chem , vol.266 , pp. 4131-4138
    • Brooker, R.J.1
  • 9
    • 0022353974 scopus 로고
    • Characterization of lactose carrier mutants which transport maltose
    • Brooker RJ, Fiebig K, et al. (1985) Characterization of lactose carrier mutants which transport maltose. J Biol Chem 260:16181-16186
    • (1985) J Biol Chem , vol.260 , pp. 16181-16186
    • Brooker, R.J.1    Fiebig, K.2
  • 10
    • 0141482545 scopus 로고
    • Isolation and nucleotide sequencing of lactose carrier mutants that transport maltose
    • Brooker RJ, Wilson TH (1985a) Isolation and nucleotide sequencing of lactose carrier mutants that transport maltose. Proc Natl Acad Sci USA 82:3959-3963
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 3959-3963
    • Brooker, R.J.1    Wilson, T.H.2
  • 11
    • 0022295159 scopus 로고
    • Isolation, characterization, and nucleotide sequences of lactose permease mutants that have acquired the ability to transport maltose
    • Brooker RJ, Wilson TH (1985b) Isolation, characterization, and nucleotide sequences of lactose permease mutants that have acquired the ability to transport maltose. Ann N Y Acad Sci 456:350
    • (1985) Ann N Y Acad Sci , vol.456 , pp. 350
    • Brooker, R.J.1    Wilson, T.H.2
  • 12
    • 0018840119 scopus 로고
    • Sequence of the lactose permease gene
    • Buchel DE, Gronenborn B, et al. (1980) Sequence of the lactose permease gene. Nature 283:541-545
    • (1980) Nature , vol.283 , pp. 541-545
    • Buchel, D.E.1    Gronenborn, B.2
  • 13
    • 0017807890 scopus 로고
    • Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid
    • Chang AC, Cohen SN (1978) Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. J Bacteriol 134:1141-1156
    • (1978) J Bacteriol , vol.134 , pp. 1141-1156
    • Chang, A.C.1    Cohen, S.N.2
  • 14
    • 0024962379 scopus 로고
    • Isolation and characterization of lactose permease mutants with an enhanced recognition of maltose and diminished recognition of cellobiose
    • Collins JC, Permuth SF, et al. (1989) Isolation and characterization of lactose permease mutants with an enhanced recognition of maltose and diminished recognition of cellobiose. J Biol Chem 264:14698-14703
    • (1989) J Biol Chem , vol.264 , pp. 14698-14703
    • Collins, J.C.1    Permuth, S.F.2
  • 15
    • 0025765577 scopus 로고
    • An analysis of lactose permease "sugar specificity" mutations which also affect the coupling between proton and lactose transport. II. Second site revertants of the thiodigalactoside-dependent proton leak by the Val177/Asn319 permease
    • Eelkema JA, O'Donnell MA, et al. (1991) An analysis of lactose permease "sugar specificity" mutations which also affect the coupling between proton and lactose transport. II. Second site revertants of the thiodigalactoside-dependent proton leak by the Val177/Asn319 permease. J Biol Chem 266:4139-4144
    • (1991) J Biol Chem , vol.266 , pp. 4139-4144
    • Eelkema, J.A.1    O'Donnell, M.A.2
  • 16
    • 0024416052 scopus 로고
    • Isolation and characterization of thiodigalactoside-resistant mutants of the lactose permease which possess an enhanced recognition for maltose
    • Franco PJ, Eelkema JA, et al. (1989) Isolation and characterization of thiodigalactoside-resistant mutants of the lactose permease which possess an enhanced recognition for maltose. J Biol Chem 264:15988-15992
    • (1989) J Biol Chem , vol.264 , pp. 15988-15992
    • Franco, P.J.1    Eelkema, J.A.2
  • 17
    • 0028234751 scopus 로고
    • Functional roles of Glu-269 and Glu-325 within the lactose permease of Escherichia coli
    • Franco PJ, Brooker RJ (1994) Functional roles of Glu-269 and Glu-325 within the lactose permease of Escherichia coli. J Biol Chem 269:7379-7386
    • (1994) J Biol Chem , vol.269 , pp. 7379-7386
    • Franco, P.J.1    Brooker, R.J.2
  • 18
    • 0030685033 scopus 로고    scopus 로고
    • Cysteine-scanning mutagenesis of helix IV and the adjoining loops in the lactose permease of Escherichia coli: Glu126 and Arg144 are essential
    • Frillingos S, Gonzalez A, et al. (1997) Cysteine-scanning mutagenesis of helix IV and the adjoining loops in the lactose permease of Escherichia coli: Glu126 and Arg144 are essential. off. Biochemistry 36:14284-14290
    • (1997) Off. Biochemistry , vol.36 , pp. 14284-14290
    • Frillingos, S.1    Gonzalez, A.2
  • 19
    • 0027355843 scopus 로고
    • Isolation of lactose permease mutants which recognize arabinose
    • Goswitz VC, Brooker RJ (1993) Isolation of lactose permease mutants which recognize arabinose. Membr Biochem 10:61-70
    • (1993) Membr Biochem , vol.10 , pp. 61-70
    • Goswitz, V.C.1    Brooker, R.J.2
  • 20
    • 0026738299 scopus 로고
    • An analysis of the side chain requirement at position 177 within the lactose permease which confers the ability to recognize maltose
    • Gram CD, Brooker RJ (1992) An analysis of the side chain requirement at position 177 within the lactose permease which confers the ability to recognize maltose. J Biol Chem 267:3841-3846
    • (1992) J Biol Chem , vol.267 , pp. 3841-3846
    • Gram, C.D.1    Brooker, R.J.2
  • 21
    • 0026660369 scopus 로고
    • Membrane transport proteins: Implications of sequence comparisons
    • Griffith JK, Baker ME, et al. (1992) Membrane transport proteins: implications of sequence comparisons. Curr Opin Cell Biol 4:684-695
    • (1992) Curr Opin Cell Biol , vol.4 , pp. 684-695
    • Griffith, J.K.1    Baker, M.E.2
  • 23
    • 0021416891 scopus 로고
    • Sugar-proton transport systems of Escherichia coli
    • Henderson PJ, Bradley S, et al. (1984) Sugar-proton transport systems of Escherichia coli. Biochem Soc Trans 12:146-148
    • (1984) Biochem Soc Trans , vol.12 , pp. 146-148
    • Henderson, P.J.1    Bradley, S.2
  • 24
    • 0037373068 scopus 로고    scopus 로고
    • Structural model for 12-helix transporters belonging to the major facilitator superfamily
    • Hirai T, Heymann JA, et al. (2003) Structural model for 12-helix transporters belonging to the major facilitator superfamily. J Bacteriol 185:1712-1718
    • (2003) J Bacteriol , vol.185 , pp. 1712-1718
    • Hirai, T.1    Heymann, J.A.2
  • 25
    • 34447253999 scopus 로고    scopus 로고
    • Sugar transport across lactose permease probed by steered molecular dynamics
    • Jensen MO, Yin Y, et al. (2007) Sugar transport across lactose permease probed by steered molecular dynamics. Biophys J 93:92-102
    • (2007) Biophys J , vol.93 , pp. 92-102
    • Jensen, M.O.1    Yin, Y.2
  • 26
    • 0037417746 scopus 로고    scopus 로고
    • Role of glutamate-126 and arginine-144 in the lactose permease of Escherichia coli
    • Johnson JL, Brooker RJ (2003) Role of glutamate-126 and arginine-144 in the lactose permease of Escherichia coli. Biochemistry 42:1095-1100
    • (2003) Biochemistry , vol.42 , pp. 1095-1100
    • Johnson, J.L.1    Brooker, R.J.2
  • 27
    • 0028925810 scopus 로고
    • Role of glycine residues in the structure and function of lactose permease, an Escherichia coli membrane transport protein
    • Jung K, Jung H, et al. (1995) Role of glycine residues in the structure and function of lactose permease, an Escherichia coli membrane transport protein. Biochemistry 34:1030-1039
    • (1995) Biochemistry , vol.34 , pp. 1030-1039
    • Jung, K.1    Jung, H.2
  • 28
    • 20444419395 scopus 로고    scopus 로고
    • Structure and mechanism of the lactose permease
    • Kaback HR (2005) Structure and mechanism of the lactose permease. C R Biol 328:557-567
    • (2005) C R Biol , vol.328 , pp. 557-567
    • Kaback, H.R.1
  • 29
    • 33745034030 scopus 로고    scopus 로고
    • Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease
    • Kasho VN, Smirnova IN, et al. (2006) Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease. J Mol Biol 358:1060-1070
    • (2006) J Mol Biol , vol.358 , pp. 1060-1070
    • Kasho, V.N.1    Smirnova, I.N.2
  • 30
    • 0025290251 scopus 로고
    • Characterization of Escherichia coli lactose carrier mutants that transport protons without a cosubstrate. Probes for the energy barrier to uncoupled transport
    • King SC, Wilson TH (1990a) Characterization of Escherichia coli lactose carrier mutants that transport protons without a cosubstrate. Probes for the energy barrier to uncoupled transport. J Biol Chem 265:9645-9651
    • (1990) J Biol Chem , vol.265 , pp. 9645-9651
    • King, S.C.1    Wilson, T.H.2
  • 31
    • 0025324528 scopus 로고
    • Identification of valine 177 as a mutation altering specificity for transport of sugars by the Escherichia coli lactose carrier. Enhanced specificity for sucrose and maltose
    • King SC, Wilson TH (1990b) Identification of valine 177 as a mutation altering specificity for transport of sugars by the Escherichia coli lactose carrier. Enhanced specificity for sucrose and maltose. J Biol Chem 265:9638-9644
    • (1990) J Biol Chem , vol.265 , pp. 9638-9644
    • King, S.C.1    Wilson, T.H.2
  • 32
    • 33947132573 scopus 로고    scopus 로고
    • Sugar binding in lactose permease: Anomeric state of a disaccharide influences binding structure
    • Klauda JB, Brooks BR (2007) Sugar binding in lactose permease: anomeric state of a disaccharide influences binding structure. J Mol Biol 367:1523-1534
    • (2007) J Mol Biol , vol.367 , pp. 1523-1534
    • Klauda, J.B.1    Brooks, B.R.2
  • 33
    • 0028138314 scopus 로고
    • Cloning and sequencing of the gene for the lactose carrier of Citrobacter freundii
    • Lee JI, Okazaki N, et al. (1994) Cloning and sequencing of the gene for the lactose carrier of Citrobacter freundii. Biochem Biophys Res Commun 203:1882-1888
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 1882-1888
    • Lee, J.I.1    Okazaki, N.2
  • 34
    • 0028026795 scopus 로고
    • Bacterial transporters
    • Maloney PC (1994) Bacterial transporters. Curr Opin Cell Biol 6:571-582
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 571-582
    • Maloney, P.C.1
  • 35
    • 0021962430 scopus 로고
    • A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose
    • Markgraf M, Bocklage H, et al. (1985) A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose. Mol Gen Genet 198:473-475
    • (1985) Mol Gen Genet , vol.198 , pp. 473-475
    • Markgraf, M.1    Bocklage, H.2
  • 36
    • 0026688406 scopus 로고
    • Evidence that the final turn of the last transmembrane helix in the lactose permease is required for folding
    • McKenna E, Hardy D, et al. (1992) Evidence that the final turn of the last transmembrane helix in the lactose permease is required for folding. J Biol Chem 267:6471-6474
    • (1992) J Biol Chem , vol.267 , pp. 6471-6474
    • McKenna, E.1    Hardy, D.2
  • 37
    • 0023698943 scopus 로고
    • The lactose carrier of Klebsiella pneumoniae M5a1; The physiology of transport and the nucleotide sequence of the lacY gene
    • McMorrow I, Chin DT, et al. (1988) The lactose carrier of Klebsiella pneumoniae M5a1; the physiology of transport and the nucleotide sequence of the lacY gene. Biochim Biophys Acta 945:315-323
    • (1988) Biochim Biophys Acta , vol.945 , pp. 315-323
    • McMorrow, I.1    Chin, D.T.2
  • 38
    • 33645320817 scopus 로고    scopus 로고
    • + symport in LacY
    • + symport in LacY. EMBO J 25:1177-1183
    • (2006) EMBO J , vol.25 , pp. 1177-1183
    • Mirza, O.1    Guan, L.2
  • 39
    • 34248194465 scopus 로고    scopus 로고
    • +-lactose symporter: Mechanical switch or Brownian ratchet?
    • +-lactose symporter: mechanical switch or Brownian ratchet? Biophys J 92:3474-3491
    • (2007) Biophys J , vol.92 , pp. 3474-3491
    • Naftalin, R.J.1    Green, N.2
  • 40
    • 14444279390 scopus 로고    scopus 로고
    • A melibiose transporter and an operon containing its gene in Enterobacter cloacae
    • Okazaki N, Jue XX, et al. (1997a) A melibiose transporter and an operon containing its gene in Enterobacter cloacae. J Bacteriol 179:4443-4445
    • (1997) J Bacteriol , vol.179 , pp. 4443-4445
    • Okazaki, N.1    Jue, X.X.2
  • 41
    • 0040090952 scopus 로고    scopus 로고
    • Sequence of a melibiose transporter gene of Enterobacter cloacae
    • Okazaki N, Jue XX, et al. (1997b) Sequence of a melibiose transporter gene of Enterobacter cloacae. Biochim Biophys Acta 1354:7-12
    • (1997) Biochim Biophys Acta , vol.1354 , pp. 7-12
    • Okazaki, N.1    Jue, X.X.2
  • 42
    • 0030989216 scopus 로고    scopus 로고
    • Characteristics of the melibiose transporter and its primary structure in Enterobacter aerogenes
    • Okazaki N, Kuroda M, et al. (1997c) Characteristics of the melibiose transporter and its primary structure in Enterobacter aerogenes. Biochim Biophys Acta 1326:83-91
    • (1997) Biochim Biophys Acta , vol.1326 , pp. 83-91
    • Okazaki, N.1    Kuroda, M.2
  • 43
    • 0024428223 scopus 로고
    • Analysis of the structural specificity of the lactose permease toward sugars
    • Olsen SG, Brooker RJ (1989) Analysis of the structural specificity of the lactose permease toward sugars. J Biol Chem 264:15982-15987
    • (1989) J Biol Chem , vol.264 , pp. 15982-15987
    • Olsen, S.G.1    Brooker, R.J.2
  • 44
    • 0027454507 scopus 로고
    • Lactose permease mutants which transport (malto)-oligosaccharides
    • Olsen SG, Greene KM, et al. (1993) Lactose permease mutants which transport (malto)-oligosaccharides. J Bacteriol 175:6269-6275
    • (1993) J Bacteriol , vol.175 , pp. 6269-6275
    • Olsen, S.G.1    Greene, K.M.2
  • 46
    • 17144406820 scopus 로고    scopus 로고
    • Prediction of the mutation-induced change in thermodynamic stabilities of membrane proteins from free energy simulations
    • Park H, Lee S (2005) Prediction of the mutation-induced change in thermodynamic stabilities of membrane proteins from free energy simulations. Biophys Chem 114:191-197
    • (2005) Biophys Chem , vol.114 , pp. 191-197
    • Park, H.1    Lee, S.2
  • 47
    • 0028987643 scopus 로고
    • Active transport by the CscB permease in Escherichia coli K-12
    • Sahin-Toth M, Frillingos S, et al. (1995) Active transport by the CscB permease in Escherichia coli K-12. Biochem Biophys Res Commun 208:1116-1123
    • (1995) Biochem Biophys Res Commun , vol.208 , pp. 1116-1123
    • Sahin-Toth, M.1    Frillingos, S.2
  • 49
    • 0017073611 scopus 로고
    • Raffinose metabolism in Escherichia coli K12. Purification and properties of a new alpha-galactosidase specified by a transmissible plasmid
    • Schmid K, Schmitt R (1976) Raffinose metabolism in Escherichia coli K12. Purification and properties of a new alpha-galactosidase specified by a transmissible plasmid. Eur J Biochem 67:95-104
    • (1976) Eur J Biochem , vol.67 , pp. 95-104
    • Schmid, K.1    Schmitt, R.2
  • 50
    • 0037946848 scopus 로고    scopus 로고
    • Altered substrate selection of the melibiose transporter (MelY) of Enterobacter cloacae involving point mutations in Leu-88, Leu-91, and Ala-182 that confer enhanced maltose transport
    • Shinnick SG, Perez SA, et al. (2003) Altered substrate selection of the melibiose transporter (MelY) of Enterobacter cloacae involving point mutations in Leu-88, Leu-91, and Ala-182 that confer enhanced maltose transport. J Bacteriol 185:3672-3677
    • (2003) J Bacteriol , vol.185 , pp. 3672-3677
    • Shinnick, S.G.1    Perez, S.A.2
  • 51
    • 0036780129 scopus 로고    scopus 로고
    • Altered sugar selection and transport conferred by spontaneous point and deletion mutations in the lactose carrier of Escherichia coli
    • Shinnick SG, Varela MF (2002) Altered sugar selection and transport conferred by spontaneous point and deletion mutations in the lactose carrier of Escherichia coli. J Membr Biol 189:191-199
    • (2002) J Membr Biol , vol.189 , pp. 191-199
    • Shinnick, S.G.1    Varela, M.F.2
  • 52
    • 0018414682 scopus 로고
    • Escherichia coli K-12 mutants that allow transport of maltose via the beta-galactoside transport system
    • Shuman HA, Beckwith J (1979) Escherichia coli K-12 mutants that allow transport of maltose via the beta-galactoside transport system. J Bacteriol 137:365-373
    • (1979) J Bacteriol , vol.137 , pp. 365-373
    • Shuman, H.A.1    Beckwith, J.2
  • 53
    • 0027972706 scopus 로고
    • Regulation of the raffinose permease of Escherichia coli by the glucose-specific enzyme IIA of the phosphoenolpyruvate:sugar phosphotransferase system
    • Titgemeyer F, Mason RE, et al. (1994) Regulation of the raffinose permease of Escherichia coli by the glucose-specific enzyme IIA of the phosphoenolpyruvate:sugar phosphotransferase system. J Bacteriol 176:543-546
    • (1994) J Bacteriol , vol.176 , pp. 543-546
    • Titgemeyer, F.1    Mason, R.E.2
  • 54
    • 33745045462 scopus 로고    scopus 로고
    • + symport by the sucrose permease of Escherichia coli relative to lactose permease
    • + symport by the sucrose permease of Escherichia coli relative to lactose permease. J Mol Biol 358:1051-1059
    • (2006) J Mol Biol , vol.358 , pp. 1051-1059
    • Vadyvaloo, V.1    Smirnova, I.N.2
  • 55
    • 0030924137 scopus 로고    scopus 로고
    • Lactose carrier mutants of Escherichia coli with changes in sugar recognition (lactose versus melibiose)
    • Varela MF, Brooker RJ, et al. (1997) Lactose carrier mutants of Escherichia coli with changes in sugar recognition (lactose versus melibiose). J Bacteriol 179:5570-5573
    • (1997) J Bacteriol , vol.179 , pp. 5570-5573
    • Varela, M.F.1    Brooker, R.J.2
  • 56
    • 0030573676 scopus 로고    scopus 로고
    • Molecular biology of the lactose carrier of Escherichia coli
    • Varela MF, Wilson TH (1996) Molecular biology of the lactose carrier of Escherichia coli. Biochim Biophys Acta 1276:21-34
    • (1996) Biochim Biophys Acta , vol.1276 , pp. 21-34
    • Varela, M.F.1    Wilson, T.H.2
  • 57
    • 0034177730 scopus 로고    scopus 로고
    • Mutants of the lactose carrier of Escherichia coli which show altered sugar recognition plus a severe defect in sugar accumulation
    • Varela MF, Wilson TH, et al. (2000) Mutants of the lactose carrier of Escherichia coli which show altered sugar recognition plus a severe defect in sugar accumulation. J Membr Biol 174:199-205
    • (2000) J Membr Biol , vol.174 , pp. 199-205
    • Varela, M.F.1    Wilson, T.H.2
  • 58
    • 33845380397 scopus 로고    scopus 로고
    • Sugar binding and protein conformational changes in lactose permease
    • Yin Y, Jensen MO, et al. (2006) Sugar binding and protein conformational changes in lactose permease. Biophys J 91:3972-3985
    • (2006) Biophys J , vol.91 , pp. 3972-3985
    • Yin, Y.1    Jensen, M.O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.