Altered myocardial gene expression reveals possible maladaptive processes in heterozygous and homozygous cardiac myosin-binding protein C knockout mice

Genomics

Volumn 91, Issue 1, 2008, Pages 52-60

  Eijssen, L M T ^a   van den Bosch, B J C ^a   Vignier, N ^b,c   Lindsey, P J ^a   van den Burg, C M M ^a   Carrier, L ^b,c,d   Doevendans, P A ^e,f   van der Vusse, G J ^a   Smeets, H J M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Cardiac hypertrophy; Cardiac myosin binding protein C; Gene expression; Microarray

Indexed keywords

CARDIAC MYOSIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOSIN BINDING PROTEIN C; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENERGY CONVERSION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENE MUTATION; HEART HYPERTROPHY; HEART LEFT VENTRICLE; HEART MUSCLE; HEART SEPTUM DEFECT; HETEROZYGOSITY; HOMOZYGOSITY; MALADJUSTMENT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; UPREGULATION;

MUS;

EID: 37448999729     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2007.09.005     Document Type: Article

References (46)

1. Bashyam M.D., Savithri G.R., Kumar M.S., Narasimhan C., and Nallari P. Molecular genetics of familial hypertrophic cardiomyopathy (FHC). J. Hum. Genet. 48 (2003) 55-64
2. Carrier L., et al. Organization and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy. Circ. Res. 80 (1997) 427-434
3. Niimura H., et al. Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy. N. Engl. J. Med. 338 (1998) 1248-1257
4. Bonne G., Carrier L., Richard P., Hainque B., and Schwartz K. Familial hypertrophic cardiomyopathy: from mutations to functional defects. Circ. Res. 83 (1998) 580-593
5. Alders M., et al. The 2373insG mutation in the MYBPC3 gene is a founder mutation, which accounts for nearly one-fourth of the HCM cases in the Netherlands. Eur. Heart J. 24 (2003) 1848-1853
6. Richard P., et al. Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. Circulation 107 (2003) 2227-2232
7. Winegrad S. Myosin binding protein C, a potential regulator of cardiac contractility. Circ. Res. 86 (2000) 6-7
8. Flashman E., Redwood C., Moolman-Smook J., and Watkins H. Cardiac myosin binding protein C: its role in physiology and disease. Circ. Res. 94 (2004) 1279-1289
9. Rottbauer W., et al. Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy: characterization of cardiac transcript and protein. J. Clin. Invest. 100 (1997) 475-482
10. Moolman J.A., et al. A newly created splice donor site in exon 25 of the MyBP-C gene is responsible for inherited hypertrophic cardiomyopathy with incomplete disease penetrance. Circulation 101 (2000) 1396-1402
11. Vignier N., et al. Cardiac myosin-binding protein C and familial hypertrophic cardiomyopathy: from mutations identification to human endomyocardial proteins analysis, 74th Scientific Sessions of the American Heart Association, 11-14 November 2001, Anaheim, CA, USA. Circulation 104 (2001) II-1 ((Suppl.), Abstract)
12. Carrier L., et al. Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovasc. Res. 63 (2004) 293-304
13. Harris S.P., et al. Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circ. Res. 90 (2002) 594-601
14. McConnell B.K., et al. Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. J. Clin. Invest. 104 (1999) 1771
15. McConnell B.K., et al. Comparison of two murine models of familial hypertrophic cardiomyopathy. Circ. Res. 88 (2001) 383-389
16. Yang Q., et al. A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J. Clin. Invest. 102 (1998) 1292-1300
17. Yang Q., Osinska H., Klevitsky R., and Robbins J. Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains. J. Mol. Cell. Cardiol. 33 (2001) 1649-1658
18. Yang Q., et al. In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy. Circ. Res. 85 (1999) 841-847
19. Cazorla O., et al. Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice. Cardiovasc. Res. 69 (2006) 370-380
20. Tanaka T.S., et al. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 9127-9132
21. Kargul G.J., et al. Verification and initial annotation of the NIA mouse 15K cDNA clone set. Nat. Genet. 28 (2001) 17-18
22. Dahlquist K.D., Salomonis N., Vranizan K., Lawlor S.C., and Conklin B.R. GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat. Genet. 31 (2002) 19-20
23. Doniger S.W., et al. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol. 4 (2003) R7
24. National Center for Biotechnology Information, http://www.ncbi.nlm.nih.gov/.
25. Becker K.G., et al. PubMatrix: a tool for multiplex literature mining. BMC Bioinformatics 4 (2003) 61
26. van den Bosch B.J.C., et al. Early and transient gene expression changes in pressure overload-induced cardiac hypertrophy in mice. Genomics 88 (2006) 480-488
27. van der Vusse G.J., Glatz J.F., Stam H.C., and Reneman R.S. Fatty acid homeostasis in the normoxic and ischemic heart. Physiol. Rev. 72 (1992) 881-940
28. Frey N., and Olson E.N. Cardiac hypertrophy: the good, the bad, and the ugly. Annu. Rev. Physiol. 65 (2003) 45-79
29. Stanley W.C., and Chandler M.P. Energy metabolism in the normal and failing heart: potential for therapeutic interventions. Heart Fail. Rev. 7 (2002) 115-130
30. van Bilsen M., Smeets P.J., Gilde A.J., and van der Vusse G.J. Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?. Cardiovasc. Res. 61 (2004) 218-226
31. Ritter O., and Neyses L. The molecular basis of myocardial hypertrophy and heart failure. Trends Mol. Med. 9 (2003) 313-321
32. Tarone G., and Lembo G. Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy. Trends Mol. Med. 9 (2003) 376-382
33. McGrath M.J., et al. Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly. J. Biol. Chem. 281 (2006) 7666-7683
34. Margulies K.B., et al. Mixed messages: transcription patterns in failing and recovering human myocardium. Circ. Res. 96 (2005) 592-599
35. Lips D.J., deWindt L.J., van Kraaij D.J., and Doevendans P.A. Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy. Eur. Heart J. 24 (2003) 883-896
36. Hedhli N., Pelat M., and Depre C. Protein turnover in cardiac cell growth and survival. Cardiovasc. Res. 68 (2005) 186-196
37. Sarikas A., et al. Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants. Cardiovasc. Res. 66 (2005) 33-44
38. Garrington T.P., and Johnson G.L. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 11 (1999) 211-218
39. Selvetella G., Hirsch E., Notte A., Tarone G., and Lembo G. Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence. Cardiovasc. Res. 63 (2004) 373-380
40. van Empel V.P., and De Windt L.J. Myocyte hypertrophy and apoptosis: a balancing act. Cardiovasc. Res. 63 (2004) 487-499
41. Charron P., et al. Genotype-phenotype correlations in familial hypertrophic cardiomyopathy: a comparison between mutations in the cardiac protein-C and the beta-myosin heavy chain genes. Eur. Heart J. 19 (1998) 139-145
42. Charron P., et al. Clinical features and prognostic implications of familial hypertrophic cardiomyopathy related to the cardiac myosin-binding protein C gene. Circulation 97 (1998) 2230-2236
43. Brazma A., et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat. Genet. 29 (2001) 365-371
44. Fare T.L., et al. Effects of atmospheric ozone on microarray data quality. Anal. Chem. 75 (2003) 4672-4675
45. Akaike H. Information theory and an extension of the maximum likelihood principle. In: Petrov B.N., and Csàki F. (Eds). Second International Symposium on Inference Theory (1973), Akadémiai Kiadó, Budapest 267-281
46. Ashburner M., et al. Gene Ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25 (2000) 25-29