Is α-dystroglycan the missing link in the mechanism of enterocyte uptake and translocation of Mycobacterium avium paratuberculosis?

Medical Hypotheses

Volumn 70, Issue 2, 2008, Pages 369-374

  Warth, Arne ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DYSTROGLYCAN; DYSTROPHIN ASSOCIATED PROTEIN COMPLEX; GLYCOCONJUGATE; INTEGRIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; BACTERIAL TRANSLOCATION; CELL INVASION; INTESTINE CELL; INTESTINE EPITHELIUM CELL; MYCOBACTERIUM AVIUM; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM PARATUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CROHN DISEASE; CYTOSKELETON; DYSTROGLYCANS; ENTEROCYTES; GLYCOCONJUGATES; HUMANS; INTEGRINS; MODELS, BIOLOGICAL; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; PARATUBERCULOSIS; RHO GTP-BINDING PROTEINS;

ANIMALIA; MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 37349119325     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.05.013     Document Type: Article

References (38)

1. Katoch V.M. Infections due to non-tuberculous mycobacteria (NTM). Indian J Med Res 120 (2004) 290-304
2. Autschbach F., Eisold S., Hinz U., et al. High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn's disease. GUT 54 (2005) 944-949
3. Sartor R.B. Does Mycobacterium avium subspecies paratuberculosis cause Crohn's disease?. GUT 54 (2005) 896-898
4. Behr M.A., and Schurr E. Mycobacteria in Crohn's disease: a persistent hypothesis. Inflamm Bowel Dis 12 (2006) 1000-1004
5. Thom K., and Forrest G. Gastrointestinal infections in immunocompromised hosts. Curr Opin Gastroenterol 22 (2006) 18-23
6. Rambukkana A., Yamada H., Zanazzi G., et al. Role of α-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Science 282 (1998) 2076-2079
7. Rambukkana A. Molecular basis for the peripheral nerve predilection of Mycobacterium leprae. Curr Opin Microbiol 4 (2001) 21-27
8. Henry M.D., and Campbell K.P. Dystroglycan inside and out. Curr Opin Cell Biol 11 (1999) 602-607
9. Winder S.J. The complexities of dystroglycan. Trends Biochem Sci 26 (2001) 118-124
10. Holt K.H., Crosbie R.H., Venzke D.P., and Campbell K.P. Biosynthesis of dystroglycan: processing of a precursor propeptide. FEBS Lett 468 (2000) 79-83
11. Durbeej M., and Campbell K.P. Biochemical characterization of the epithelial dystroglycan complex. J Biol Chem 274 (1999) 26609-26616
12. Driss A., Charrier L., Yan Y., Nduati V., Sitaraman S., and Merlin D. Dystroglycan receptor is involved in integrin activation in intestinal epithelia. Am J Physiol Gastrointest Liver Physiol 290 (2006) 1228-1242
13. Sgambato A., Migaldi M., Montanari M., et al. Dystroglycan expression is frequently reduced in human breast and colon cancers and is associated with tumor progression. Am J Pathol 162 (2003) 849-860
14. Sangari F.J., Parker A., and Bermudez L.E. Mycobacterium avium interactions with macrophages and intestinal epithelial cells. Front Biosci 4 (1999) 582-588
15. Hsu N, Goodman JR, Young LS, Bermudez LE. Interaction between Mycobacterium avium complex and intestinal mucosal cells in vivo. Abstracts, Ed:, 36th ICAAC, American Society for Microbiology; 1996.
16. Bermudez LE, Sangari FJ, Petrofsky M, Goodman J. Mycobacterium avium invasion of intestinal mucosal cells occurs more frequently through enterocytes than M cells and primarily by the interaction with glycoconjugates. Molecular Signals; 1998.
17. Bermudez L.E., and Young L.S. Factors affecting invasion of HT-29 and HEp-2 epithelial cells by organisms of the Mycobacterium avium complex. Infect Immun 62 (1994) 2021-2026
18. Damsker B., and Bottone E.J. Mycobacterium avium-Mycobacterium intracellulare from the intestinal tracts of patients with the acquired immunodeficiency syndrome: concepts regarding acquisition and pathogenesis. J Infect Dis 151 (1985) 179-180
19. Gray J.R., and Rabeneck L. Atypical mycobacterial infection of the gastrointestinal tract in AIDS patients. Am J Gastroenterol 84 (1989) 1521-1525
20. Sangari F.J., Goodman J., and Bermudez L.E. Mycobacterium avium enters intestinal epithelial cells through the apical membrane, but not by the basolateral surface, activates small GTPase Rho and, once within epithelial cells, expresses an invasive phenotype. Cell Microbiol 6 (2000) 561-568
21. Schorey J.S., Holsti M.A., Ratliff T.L., Allen P.M., and Brown E.J. Characterization of the fibronectin-attachment protein of Mycobacterium avium reveals a fibronectin-binding motif conserved among mycobacteria. Mol Microbiol 21 (1996) 321-329
22. Secott T.E., Lin T.L., and Wu C.C. Mycobacterium avium subsp. Paratuberculosis fibronectin attachement protein facilitates M-cell targeting and invasion through a fibronectin bridge with host integrins. Infect Immun 72 (2004) 3724-3732
23. Turck N., Gross I., Gendry P., Stutzmann J., Freund J.N., Kedinger M., et al. Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells. Exp Cell Res 303 (2005) 494-503
24. Ervasti J.M., and Campbell K.P. Membrane organization of the dystrophin-glycoprotein complex. Cell 66 (1991) 1121-1131
25. Zhou Y.W., Thomason D.B., Gullberg D., and Jarrett H.W. Binding of laminin alpha1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling. Biochemistry 45 (2006) 2042-2052
26. Ilsley J.L., Sudol M., and Winder S.J. The interaction of dystrophin with beta-dystroglycan is regulated by tyrosine phosphorylation. Cell Signal 13 (2001) 625-632
27. Sotgia F., Bonuccelli G., Bedford M., Brancaccio A., Mayer U., Wilson M.T., et al. Localization of phospho-beta-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo. Biochemistry 42 (2003) 7110-7123
28. Zhan Y., Tremblay M.R., Melian N., and Carbonetto S. Evidence that dystroglycan is associated with dynamin and regulates endocytosis. J Biol Chem 280 (2005) 18015-18024
29. Unsworth K.E., Mazurkiewicz P., Senf F., Zettl M., McNiven M., Way M., et al. Dynamin is required for F-actin assembly and pedestal formation by enteropathogenic Escherichia coli (EPEC). Cell Microbiol 9 (2007) 438-449
30. Russell D.G., Dant J., and Sturgill-Koszycki S. Mycobacterium avium- and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion-competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemma. J Immunol 156 (1996) 4764-4773
31. Chockalingam P.S., Cholera R., Oak S.A., Zheng Y., Jarrett H.W., and Thomason D.B. Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Am J Physiol Cell Physiol 283 (2002) C500-C511
32. Rao S.P., Gehlsen K.R., and Catanzaro A. Identification of a β1 integrin an Mycobacterium avium-Mycobacterium intracellulare. Infect Immun 60 (1992) 3652-3657
33. Singh J., Itahana Y., Knight-Krajewski S., Kanagawa M., Campbell K.P., Bissell M.J., et al. Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells. Cancer Res 64 (2004) 6152-6159
34. Macdonald JK, McDonald JW. Natalizumab for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2006 Jul 19;3:CD006097.
35. Wells S.J., Ott S.L., and Seitzinger A.H. Key health issues for dairy cattle - new and old. J Dairy Sci 81 (1998) 3029-3035
36. Weiss D.J., Evanson O.A., and Souza C.D. Mucosal immune response in cattle with subclinical Johne's disease. Vet Pathol 43 (2006) 127-135
37. Martin P.T. The dystroglycanopathies: the new disorders of O-linked glycosylation. Semin Pediatr Neurol 12 (2005) 152-158
38. Brockington M., and Muntoni F. The modulation of skeletal muscle glycosylation as a potential therapeutic intervention in muscular dystrophies. Acta Myol 24 (2005) 217-221