Importance of Interleukin-7 in the Development of Experimental Graft-Versus-Host Disease

Biology of Blood and Marrow Transplantation

Volumn 14, Issue 1, 2008, Pages 16-27

  Chung, Brile ^a   Dudl, Eric ^b   Toyama, Akira ^b   Barsky, Lora ^b   Weinberg, Kenneth I ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Allogeneic; Bone marrow transplantation; Graft versus host disease; Interleukin 7; T lymphocyte

Indexed keywords

INTERLEUKIN 7; PHOSPHATE BUFFERED SALINE; RECOMBINANT INTERLEUKIN 7;

ALLOGENIC BONE MARROW TRANSPLANTATION; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BONE MARROW CELL; C57BL 6 MOUSE; CELL SURVIVAL; CONGENIC STRAIN; CONTROLLED STUDY; DONOR; EXPERIMENTAL MODEL; FEMALE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LYMPHOCYTE PROLIFERATION; MALE; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; T CELL DEPLETION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THROMBOCYTOPOIESIS;

ANIMALS; BONE MARROW TRANSPLANTATION; DISEASE MODELS, ANIMAL; GRAFT VS HOST DISEASE; HUMANS; INTERLEUKIN-7; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, CONGENIC; MICE, INBRED C57BL; SURVIVAL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 37349115259     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2007.07.015     Document Type: Article

References (47)

1. Ferrara J.M.L. Cytokine dysregulation as a mechanism of graft-versus-host disease. Curr Opin Immunol 5 (1993) 794-799
2. Antin J.H., and Verra J.L. Cytokine dysregulation and acute graft-versus-host disease. Blood 80 (1992) 2964-2968
3. + cells in anti-class II H-2 differences. J Immunol 144 (1990) 2946-2954
4. Korngold R., and Sprent J. Bone Marrow Transplantation (1994), Blackwell Scientific, London p. 220-230
5. Nikolic B., Lee S., Bronson R.T., et al. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest 105 (2000) 1289-1298
6. + cells in class I-different hosts. J Exp Med 167 (1988) 556-560
7. Ferrara J.L., and Deeg H.J. Graft-versus-host disease. N Engl J Med 324 (1991) 667-674
8. Weinberg K.I., Annett G., Kashyap A., et al. The effect of thymic function on immunocompetence following bone marrow transplantation. Biol Blood Marrow Transplant 1 (1995) 18-23
9. Chung B., Barbra-Burnham L., Barsky L., et al. Radiosensitivity of thymic IL-7 production and thymopoiesis after bone marrow transplant (BMT). Blood 99 (2001) 4592-4600
10. Atkinson K. Reconstruction of the hematopoietic and immune systems after marrow transplantation. Bone Marrow Transplant 5 (1990) 209-226
11. Lum L.G. The kinetics of immune reconstitution after human marrow transplantation. Blood 69 (1987) 369-380
12. Miller R.A., Daley J., Ghalie R., et al. Clonal analysis of T-cell deficiencies in autotransplant recipients. Blood 77 (1991) 1845-1850
13. Rodewald H.R., Kretzschmar K., Swat W., et al. Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. Immunity 3 (1995) 313-319
14. Murray R., Suda T., Wrighton N., et al. IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. Int Immunol 169 (1989) 707-716
15. Pechon J.J., Morrissey P.J., Grabstein K.H., et al. Early lymphocyte expansion is severely impaired in interleukin-7 receptor-deficient mice. J Exp Med 180 (1994) 1955-1960
16. Von Freeden-Jeffry U., Vieira P., Lucian L.A., et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181 (1995) 1519-1526
17. Somberg R., Robinson J.P., and Felsburg P. T lymphocyte development and function in dogs with X-linked severe combined immune deficiency. J Immunol 153 (1994) 4006-4015
18. Noguchi M., Yi H., Rosenblatt H.M., et al. Interleukin-2 receptor γ-chain mutation results in X-linked severe combined immune deficiency in humans. Cell 73 (1993) 147-157
19. Bolotin E., Smith S., Smogoreswka E.M., et al. Enhancement of thymopoiesis after bone marrow transplant by in vivo IL-7. Blood 88 (1996) 1887-1894
20. Mackall C.L., Fry T.J., Bare C., et al. IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation. Blood 97 (2001) 1491-1497
21. Sudo T.S., Nishikawa N., Ohno N., et al. Expression and function of the interleukin-7 receptor in murine lymphocytes. Proc Natl Acad Sci U S A 90 (1993) 9125-9129
22. Maraskovsky E., Teepe M., Morrissey P.J., et al. Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells. J Immunol 157 (1996) 5315-5323
23. Tan J.T., Dudl E., LeRoy E., et al. IL-7 is critical for homeostatic proliferation and survival of naïve T cells. Proc Natl Acad Sci U S A 98 (2001) 8732-8737
24. Schluns K.S., Kieper W.C., Jameson S.C., et al. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol 1 (2000) 426-432
25. Kondrack R.M., Harbertson J., Tan J.T., et al. Interleukin-7 regulates the survival and generation of memory CD4 cells. J Exp Med 198 (2003) 1797-1806
26. Vella A.T., Dow S., Potter T.A., et al. Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci U S A 95 (1998) 3810-3815
27. Gringhuis S.I., de Leij L.F., Verschuren E.W., et al. Interleukin-7 up-regulates the interleukin-2 gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1. Blood 90 (1997) 2690-2700
28. van Roon J.A., Glaudemans K.A., Bijlsma J.W., et al. Interleukin-7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis. Ann Rheum Dis 62 (2003) 113-119
29. + T cells from human cord blood. Immunol Lett 59 (1997) 21-28
30. Alpdogan O., Schmaltz C., Muriglan S.J., et al. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 98 (2001) 2256-2265
31. Sinha M.L., Fry T.J., Fowler D.H., et al. Interleukin-7 worsens graft-versus-host disease. Blood 100 (2002) 2642-2649
32. Alpdogan O., Muriglan S.J., Eng J.M., et al. IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. J Clin Invest 112 (2003) 1095-1107
33. Cooke K.R., Kobzik L., Martin T.R., et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation. I. The role of minor H antigens and endotoxin. Blood 88 (1996) 3230-3239
34. Maury S., Salomon B., Klatzmann D., et al. Division rate and phenotypic differences discriminate alloreactive and nonalloreactive T cells transferred in lethally irradiated mice. Blood 98 (2001) 3156-3158
35. Blazar B.R., Lees C.J., Martin P.J., et al. Host T cells resist graft-versus-host disease by donor leukocyte infusions. J Immunol 165 (2000) 4901-4909
36. + cells. J Exp Med 195 (2002) 1523-1532
37. Schluns K.S., and Lefrancois L. Cytokine control of memory T cell development and survival. Nat Rev Immunol 3 (2003) 269-279
38. Fry T.J., Connick E., Fallon J., et al. A potential role for interleukin-7 in T-cell homeostasis. Blood 97 (2001) 2983-2990
39. Mathur A., Vallera D.A., Taylor P.A., et al. Effect of IL-7 or IL-4 on reconstitution of donor lymphoid cells in congenic bone marrow transplantation. Bone Marrow Transplant 16 (1995) 119-124
40. Gendelman M., Hecht T., Logan B., et al. Host conditioning is a primary determinant in modulating the effect of IL-7 on murine graft-versus-host disease. J Immunol 172 (2004) 3328-3336
41. Bolotin E., Annett G., Parkman R., et al. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant 23 (1999) 783-788
42. Llano A., Barretina J., Gutierrez A., et al. Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type1-positive individuals. J Virol 75 (2001) 10319-10325
43. Napolitano L.A., Grant R.M., Deeks S.G., et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7 (2001) 73-79
44. Sakajuchi S., Takahashi T., and Nishizuka Y. Study on cellular events on post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med 156 (1982) 1577-1586
45. Sakaguchi S., and Sakaguchi N. Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for the induction of autoimmune disease. J Exp Med 172 (1990) 537-545
46. Alpdogan O., and van den Brink M.R. IL-7 and IL-15: therapeutic cytokines for immunodeficiency. Trends Immunol 26 (2005) 56-64
47. Chung B., Dudl E.P., Min D., Barsky L., et al. Prevention of graft-versus-host disease by anti-IL-7Rα antibody. Blood 110 (2007) 2803-2810