Safety assessment of Ylang-Ylang (Cananga spp.) as a food ingredient

Food and Chemical Toxicology

Volumn 46, Issue 2, 2008, Pages 433-445

  Burdock, George A ^a   Carabin, Ioana G ^b  

^a Burdock Group   (United States)

^b Women in Science   (United States)

Author keywords

Burdock; Food additive; GRAS; Toxicity; Ylang Ylang

Indexed keywords

ANISOLE DERIVATIVE; BENZYL BENZOATE; ESSENTIAL OIL; FLAVORING AGENT; FRAGRANCE; LIRIODENINE; NEQUINATE; WATER; YLANG YLANG OIL;

ABSORPTION; ACANTHAMOEBA; ACUTE TOXICITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; BIOCHEMISTRY; CHEMICAL COMPOSITION; CONTACT DERMATITIS; DISTILLATION; FLOWER; FOOD ALLERGY; FOOD INDUSTRY; FOOD INTAKE; FOOD SAFETY; HISTORY; HUMAN; HYPERPIGMENTATION; INHALATION; LAW; METABOLISM; MUTAGENICITY; NONHUMAN; PATCH TEST; REVIEW; RISK ASSESSMENT; SKIN IRRITATION; SKIN SENSITIZATION; SLEEP;

ANIMALS; CANANGA; DERMATITIS; FLAVORING AGENTS; HUMANS; PLANT OILS; SKIN TESTS;

ANIMALIA; ARCTIUM; CANANGA; CANANGA ODORATA;

EID: 37349110317     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.09.105     Document Type: Review

References (73)

1. Acda R.I., Reblora M.A., and Gonzales E.D. Solvent extraction of essential oils from Ylang-Ylang (Cananga odorata). Philippine Agriculturist 78 (1995) 345-353
2. Arctander, S. 1960. Ylang-Ylang oil. In: Perfume and Flavor Materials of Natural Origin. Published by Author, Elizabeth, NJ. pp. 668-671.
3. Belsito D.V., Fowler Jr. J.F., Sasseville D., Marks Jr. J.G., De Leo V.A., and Storrs F.J. Delayed-type hypersensitivity to fragrance materials in a select North American population. Dermatitis 17 (2006) 23-28
4. Bauer K., Garbe D., and Surburg H. Ylang-Ylang oil. Common Fragrance and Flavor Materials: Preparation. third ed. Properties and Uses (1997), Wiley-VCH, Verlag GmbH, Weinheim, Germany 218
5. Bronaugh R.L., Wester R.C., Bucks D., Maibach H.I., and Sarason R. In vivo percutaneous absorption of fragrance ingredients in Rhesus monkeys and humans. Food and Chemical Toxicology 28 (1990) 369-373
6. Buccellato F. Ylang survey. Perfum. Flavor. 7 (1982) 9-12
7. Burdock G.A. Ylang-Ylang oil. Encyclopedia of Food and Color Additives (1997), CRC Press, Boca Raton, FL 2979-2981
8. Burdock G.A. Regulation of flavor ingredients. In: Kotsonis F.N., and Mackey M. (Eds). Nutritional Toxicology. second ed. (2002), Taylor and Francis, New York, NY 316-339
9. Burdock G.A. Ylang-Ylang oil. Fenaroli's Handbook of Flavor Ingredients. fourth ed. (2002), CRC Press, Boca Raton, FL 1802
10. Burfield T. Safety of essential oils. International Journal of Aromatherapy 10 (2000) 16-29
11. Chu D.M., Miles H., Toney D., Ngyuen C., and Marciano-Cabral F. Amebicidal activity of plant extracts from Southeast Asia on Acanthamoeba spp. Parasitology Research 84 (1998) 746-752
12. Clydesdale F.M. Ylang-Ylang oil. Food Additives: Toxicology, Regulation, and Properties (1997), CRC Press, Boca Raton, FL CD-ROM
13. Cockayne S.E., and Gawkrodger D.J. Occupational contact dermatitis in an aromatherapist. Contact Dermatitis 37 (1997) 306-307
14. Delespaul Q., De Billerbeck V.G., Roques C.G., Michel G., Marquier-Vinuales C., and Bessiere J.M. The antifungal activity of essential oils as determined by different screening methods. Journal of Essential Oil Research 12 (2000) 256-266
15. Duke J.A. Cananga odoratoa (Lam.) Hook. f & Thomson. Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants (1992), CRC Press, Boca Raton, FL 126
16. Ernst E. Adverse effects of herbal drugs in dermatology. British Journal of Dermatology 143 (2000) 923-929
17. Facciola S. Canaga odorata - Ylang-Ylang. Cornucopia: A Source Book of Edible Plants (1990), Kampong Publications, Vista, CA 12
18. FDA, 2003. Toxicological Principles for the Safety Assessment of Food Ingredients (Redbook 2000) US Food and Drug Administration, Washington, DC.
19. Frosch P.J., Johansen J.D., Menne T., Pirker C., Rastogi S.C., Andersen K.E., Bruze M., Goossens A., Lepoittevin J.P., and White I.R. Further important sensitizers in patients sensitive to fragrances. II. Reactivity to essential oils. Contact Dermatitis 47 (2002) 279-287
20. Fujii T., Furukawa S., and Suzuki S. Compounded perfumes for toilet goods. nonirritative compounded perfumes for soaps. Yukagaku 21 (1972) 904-908 (in Japanese)
21. Fukayama M.Y., Easterday O.D., Serafino P.A., Renskers K.J., North-Root H., and Schrankel K.R. Subchronic inhalation studies of complex fragrance mixtures in rats and hamsters. Toxicol. Lett. 111 (1999) 175-187
22. Greuter, W. 2000. Ylang Ylang. In International Code of Botanical Nomenclature (Saint Louis Code). Adopted by the Sixteenth International Botanical Congress. St. Louis, Missouri, July-August 1999. Koeltz Scientific Books, D-61453 Konigstein, Germany. p. 280.
23. Hall R.L., and Oser B.L. Recent progress in the consideration of flavoring ingredients under the food additives amendment III. GRAS Substances. Ylang-Ylang oil. Food Technol. 19 (1965) 299
24. Hongratanaworakit T., and Buchbauer G. Evaluation of the harmonizing effect of ylang-ylang oil on humans after inhalation. Planta Medica 70 (2004) 632-636
25. Hongratanaworakit T., and Buchbauer G. Relaxing effect of Ylang-Ylang oil on humans after transdermal absorption. Phytotherapy Res. 20 (2006) 758-763
26. Horne D., Holm M., Oberg C., Chao S., and Young D.G. Antimicrobial effects of essential oils on Streptococcus pneumoniae. J. Essential Oil Res. 13 (2001) 387-392
27. Hsieh T.J., Chang F.R., Chia Y.C., Chen C.Y., Chiu H.F., and Wu Y.C. Cytotoxic constituents of the fruits of Cananga odorata. J. Natural Prod. 64 (2001) 616-619
28. Hsieh T.J., Chang F.R., and Wu Y.C. The constituents of Cananga odorata. J. Chinese Chem. Soc. 46 (1999) 607-611
29. Ilmberger J., Heuberger E., Mahrhofer C., Dessovic H., Kowarik D., and Buchbauer G. The influence of essential oils on human attention. I: Alertness. Chem. Senses 26 (2001) 239-245
30. Imokawa G., and Kawai M. Differential hypermelanosis induced by allergic contact dermatitis. J. Invest. Dermatol. 89 (1987) 540-546
31. Itoh M., Hosono K., Kantoh H., Kinoshita M., Yamada K., Kurosaka R., and Nishimura M. Patch tests results with cosmetic ingredients conducted between 1978 and 1986. Nippon Koshohin Kagakkaishi J. Jpn. Cosmetic Sci. Soc. 12 (1988) 27-41 (in Japanese)
32. Kanof, N.B. 1971. Report to RIFM, 8 February (cited in Opdyke, 1974).
33. Kenerva L., Estlander T., and Jolanki R. Occupational allergic contact dermatitis caused by Ylang-Ylang oil. Contact Dermatitis 33 (1995) 198-199
34. Kligman, A.M. 1971. Report to RIFM, 20 April (cited in Opdyke 1974).
35. Kligman, A.M. 1972. Report to the Research Institute for Fragrance Materials (RIFM), 18 February (cited in Opdyke 1974).
36. Komori T., Matsumoto T., Motomura E., and Shiroyama T. The sleep-enhancing effect of valerian inhalation and sleep-shortening effect of lemon inhalation. Chem. Senses 31 (2006) 731-737
37. Komori T., Tanida M., Kikuchi A., Shoji K., Nakamura S., and Nomura J. Effects of odorant inhalation on pentobarbital-induced sleep time in rats. Human Psychopharmacol. 12 (1997) 601
38. Larsen W., Nakayama H., Fischer T., Elsner P., Frosch P., Burrows D., Jordan W., Shaw S., Wilkinson J., Marks J., Sugawara M., Nethercott M., and Nethercott J. Fragrance contact dermatitis: A worldwide multicenter investigation (Part III). Contact Dermatitis 46 (2002) 141-444
39. Larsen W., Nakayama H., Lindberg M., Fischer T., Elsner P., Burrows D., Jordan W., Shaw S., Wilkinson J., Marks J., Sugawara M., and Nethercott J. Fragrance contact dermatitis: A worldwide multicenter investigation (Part I). Am. J. Contact Dermatitis - Official J. Am. Contact Dermatitis Soc. 7 (1996) 77-83
40. Lebcoeuf M., Steith J., and Cave A. Alkaloids of Annonaceae: Alkaloids of the barks of Cananga odorata, Hook. F. & Thomson. Ann. Pharm. Fr. 33 (1973) 43-47
41. Lucas, C.D., Putnam, J.M., Hallagan, J.B. 1999. Ylang ylang oil. In 1995 Poundage and Technical Effects Update Survey. Flavor and Extract Manufacturers' Association of the United States, Washington, DC.
42. Majors, P.A. 1971a. Report to RIFM, 13 April (cited in Opdyke, 1974).
43. Majors, P.A. 1971b. Report to RIFM, 23 August (cited in Opdyke, 1974).
44. Majors, P.A. 1972. Report to RIFM, 21 March (cited in Opdyke, 1974).
45. Mantle D., Anderton J.G., Falkous G., Barnes M., Jones P., and Perry E.K. Comparison of methods for determination of total antioxidant status: Application to analysis of medicinal plant essential oils. Comparitive Biochem. Physiol. Part B: Biochem. Molecular Biol. 121B (1998) 385-391
46. Maruzzella J.C., and Lichtenstein M.B. The in vitro antibacterial activity of oils. J. Am. Pharma. Assoc. 45 (1956) 378 (cited in Opdyke 1976)
47. Maudsley F., and Kerr K.G. Microbiological safety of essential oils used in complementary therapies and the activity of these compounds against bacterial and fungal pathogens. Supportive Care in Cancer 7 (1999) 100-102
48. Mitchell D.M., and Beck M.H. Contact allergy to benzyl alcohol in a cutting oil deodorant. Contact Dermatitis 18 (1988) 301-302
49. Moreno, O.M. 1973. Report to RIFM, 7 November (cited in Opdyke, 1974).
50. MRCA, 1965. Market Research Corporation of America (MRCA), in conjunction with the "Food intake and nutritive value of the diets of men, women and children in United States, Spring 1965". United States Department of Agriculture, Washington, DC.
51. NACGM, 1977. Ylang ylang oil (Personal Communication).
52. NAS, 1989. Ylang ylang oil. In 1987 Poundage and Technical Effects Update of Substances Added to Food. National Research Council, National Academy of Sciences, Washington, DC. p. 608.
53. NMCD, 2004. Ylang ylang oil. Natural Medicines Comprehensive Database. (subscription based product) (Accessed 8.7.07).
54. Opdyke D.L.J. Reviews on fragrance raw materials. Ylang-Ylang oil. Food Cosmetics Toxicol. 12 Suppl. (1974) 1015-1016
55. Ontengco, D., Torres, R. 2000. Antibacterial activity of Ylang-Ylang essential oil. Proceedings of the 29th Annual Convention of the Philippine Society for Microbiology: On line with the nation in ensuring food security, health and ecosystem stability pp. 177-178 (Abstract only).
56. Pratt M.D., Belsito D.V., DeLeo V.A., Fowler Jr. J.F., Fransway A.F., Maibach H.E., Marks J.G., Mathias C.G.T., Rietschel R.L., Sasseville D., Sherertz E.F., Storrs F.J., Taylor J.S., and Zug K. North American Contact Dermatitis Group patch-test results, 2001-2002 study period. Dermatitis 15 (2004) 176-183
57. Rao J.U.M., Giri G.S., Hanumaiah T., and Rao K.V.J. Sampangine, a new alkaloid from Cananga odorata. J. Natural Prod. 49 (1986) 346-347
58. Romaguera C., and Vilaplana J. Occupational contact dermatitis from Ylang-Ylang oil. Contact Dermatitis 43 (2000) 251
59. Rudzki E., and Gryzwa Z. Allergy to perfume mixture. Contact Dermatitis 15 (1986) 115-116
60. Rudzki E., and Grzywa Z. Balsam of Peru as screening agent for essential oils sensitivity. Dermatologica 155 (1977) 115-121
61. Rudzki E., Rebandel P., and Grzywa Z. Occupational dermatitis from cosmetic creams. Contact Dermatitis 29 (1993) 210
62. Simpson E.L., Law S.V., and Storrs F.J. Prevalence of botanical extract allergy in patients with contact dermatitis. Dermatitis 15 (2004) 67-72
63. Stashenko E.E., Prada N.Q., and Martinez J.R. HRGC/FID/NPD and HRGC/MSD study of Colombian Ylang-Ylang (Cananga odorata) oils obtained by different extraction techniques. J. High Resolut. Chromatogr. 19 (1996) 353-358
64. Timmer R., Ter Heide R., De Valois P.J., and Wobben H.J. Analysis of the acid fraction of Ylang-Ylang oil (Cananga odorata Forma genuina). Int. Flavours Food Additives 6 (1975) 189
65. Tisserand R., and Balacs T. Ylang ylang. Essential Oil Safety (1995), Churchill Livingstone, New York, NY 41,211
66. Toyoda, T., Watanabe, S., Kawasaki, M., Nakayama, H., Sugawara, M. 1989. Dehydrodiisoeugenol found in Ylang-Ylang oil. Symposium on Contact Dermatitis and Patch Test X Held at the 13th Annual Meeting of Japan Patch Test Research Group, Nagoya, Japan, December 3-4, 1988. Skin Research 31, 1989-43 (in Japanese).
67. Tradewinds, F. Ylang-Ylang. Tradewinds Fruit. .
68. Tropilab Inc Cananga odorata - Ylang-Ylang. Tropilab Inc. .
69. Urbach, F., Forbes, P.D. 1973. Report to RIFM, 27 November (cited in Opdyke 1974).
70. Uter W., Geier J., Schnuch A., and Frosch P.J. Patch test results with patients' own perfumes, deodorants and shaving lotions: results of the IVDK 1998-2002. J. European Acad. Dermatol. Venereol. 21 (2007) 374-379
71. Watanabe S. A simple screening test for chemical compounds to induce delayed allergic contact dermatitis: Use of Bacillus subtilis spore REC-assay in place of animal methods. Pharmacometrics 47 (1994) 177-198 (in Japanese)
72. Wei A., and Shibamoto T. Antioxidant activities and volatile constituents of various essential oils. J. Agric. Food Chem. 55 (2007) 1737-1742
73. Woo S.H., Reynolds M.C., Sun N.J., Cassady J.M., and Snapka R.M. Inhibition of topoisomerase II by liriodenine. Biochem. Pharmacol. 54 (1997) 467-473