Beneficial effects of heart rate reduction on cardiac mechanics and energetics in patients with left ventricular dysfunction

Japanese Circulation Journal

Volumn 63, Issue 12, 1999, Pages 957-964

  Shinke, Toshiro ^a   Takeuchi, Motoshi ^a   Takaoka, Hideyuki ^a   Yokoyama, Mitsuhiro ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

Contractility; Heart rate; Left ventricular dysfunction; Oxygen consumption

Indexed keywords

ZATEBRADINE;

ADULT; AGED; ARTICLE; BRADYCARDIA; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY SINUS; CORONARY SINUS BLOOD FLOW; FEMALE; HEART ATRIUM PACING; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE OXYGEN CONSUMPTION; HEART RATE; HUMAN; MALE; MATHEMATICAL ANALYSIS; TREATMENT OUTCOME;

BENZAZEPINES; BRADYCARDIA; CARDIOTONIC AGENTS; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXYGEN CONSUMPTION; TACHYCARDIA; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0033429612     PISSN: 00471828     EISSN: None     Source Type: Journal    
DOI: 10.1253/jcj.63.957     Document Type: Article

References (53)

1. Mulieri LA, Hasenfuss G, Leavit B, Allen PD, Alpert NR: Altered myocardial force-frequency relation in human heart failure. Circulation 1992; 85: 1743-1750
2. Yamakado T, Yamada N, Tarumi T, Nakamura M, Nakano T: Left ventricular inotropic and lusitropic responses to pacing-induced tachycardia in patients with varying degree of ventricular dysfunction. Am Heart J 1998; 135: 584-591
3. Inagaki M, Yokota M, IzawaH, Ishiki R, Nagata K, Iwase M, et al: Impaired force-frequency relations in patients with hypertensive left ventricular hypertrophy: A possible physiological marker of the transition from physiological to pathological hypertrophy. Circulation 1999; 99: 1822-1830
4. Fenelon G: Tachycardiomyopathy: Mechanisms and clinical implications. PACE 1996; 19: 95-106
5. Tomita M, Spinale FG, Crawford FA, Zile MR: Changes in left ventricular volume, mass and function during the development and regression of supraventricular tachycardia induced cardiomyopathy: Disparity between recovery of systolic and diastolic function. Circulation 1991; 83: 635-644
6. Hudlicka O, Wright AJA: Capillary diffusion capacity in long-term bradycardially paced rabbit hearts. Int J Microcirc Clin Exp 1987; 5: 395-399
7. Waagstein F, Bristow MR, Swedberg K: Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy: Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group. Lancet 1993; 342: 1441-1446
8. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 1999; 353: 9-13
9. Kjekshus JK: Importance of heart rate in determining beta-blocker efficacy in acute and long-term acute myocardial intervention trials. Am J Cardiol 1986; 57: 43F-49F
10. Brown MD, Hudlicka O: Protective effects of long-term bradycardial pacing against catecholamine-induced myocardial damage in rabbit hearts. Circ Res 1988; 62: 965-974
11. Yamakawa H, Takeuchi M, Takaoka H, Hata K, Mori M, Yokoyama M: Negative chronotropic effect of beta-blockade therapy reduces myocardial oxygen expenditure for nonmechanical work. Circulation 1996; 94: 340-345
12. Feldman MD, Alderman JD, Aroesty JM, Royal HD, Ferguson JJ: Depression of systolic and diastolic myocardial reserve during atrial pacing tachycardia in patients with dilated cardiomyopathy. J Clin Invest 1988; 82: 1661-1669
13. Raff GL, Glantz SA: Volume loading shows left ventricular isovolumic relaxation rate: Evidence of load-dependent relaxation in the intact dog heart. Circ Res 1981; 48: 813-824
14. Takaoka H, Takeuchi M, Odake M, Hayashi Y, Hata K, Mori M, et al: Comparison of hemodynamic determinants for myocardial oxygen consumption under different contractile states in the human ventricle. Circulation 1993; 87: 59-69
15. Takaoka H, Takeuchi M, Odake M, Yokoyama M: Assessment of myocardial oxygen consumption (VO2) and systolic pressure-volume area (PVA) in human hearts. Eur Heart J 1992; 13: 85-90
16. Takeuchi M, Igarashi Y, Tomimoto S, Odake M, Hayashi T, Tsukamoto T, et al: Single-beat estimation of the slope of the end-systolic pressure-volume relation in the human left ventricle. Circulation 1991; 83: 202-212
17. Kass DA, Meidei M, Graves W, Brinker JA, Maughan WL: Use of conductance (volume) catheter and transient inferior vena caval occlusion for rapid determination of pressure-volume relationships in man. Cathet Cardiovasc Diagn 1988; 62: 1237-1246
18. Odake M, Takeuchi M, Yokoyama M: Assessment of left ventricular volume using the conductance catheter comparison with bi-plane cineangiography. Eur Heart J 1992; 13(Suppl E): 22-27
19. Suga H: Ventricular energetics. Physiol Rev 1990; 70: 247-277
20. Little WC, Cheng CP, Peterson T, Vinten-Johansen J: Response of the left ventricular pressure-volume relation in conscious dogs to a wide range of contractile states. Circulation 1988; 78: 736-745
21. Grossman W, Braunwald E, Mann T, McLaurin LP, Green LH: Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relation. Circulation 1977; 56: 845-852
22. Sunagawa K, Maughan WL, Sagawa K: Optimal arterial resistance for the maximal stroke work studied in the isolated canine left ventricle. Circ Res 1985; 56: 586-595
23. Bairn DS, Rothman MT, Harrison DC: Simultaneous measurement of coronary venous blood flow and oxygen saturation during transient alterations in myocardial oxygen supply and demand. Am J Cardiol 1982; 49: 743-752
24. Breall JA, Watanabe J, Grossman W: Effect of Zatebradine on contractility, relaxation and coronary blood flow. J Am Coll Cordiol 1993; 21: 471-477
25. Schipke JD, Harasawa Y, Sugiura S, Alexander J Jr, Burkhoff D: Effect of bradycardiac agent on the isolated blood-perfused canine heart. Cardiovasc Drugs Ther 1991; 5: 481-488
26. Riley DC, Gross GJ, Kampine JP, Waltier DC: Specific bradycardiac agents, a new therapeutic modality for anesthesiology: hemodynamic effects of ULFS-49 and propranolol in conscious and isoflurane-anesthetized dogs. Anesthesiology 1987; 67: 707-716
27. Blinks JR, Weser JK: Analysis of the effects of changes in the rate and rhythm upon myocardial contractility. J Pharmacol Exp Ther 1961; 134: 373-389
28. Pieske B, Kretschmann B, Meyer M: Alteration in intracellular calcium handling associated with the inverse force-frequency relation in human dilated cardiomyopathy. Circulation 1995; 92: 1169-1178
29. Freeman GL, Little WC, O'Rourke RA: Influence of heart rate on left ventricular performance in conscious dogs. Circulation 1987; 61: 455-464
30. Allen DG, Blinks JR: Calcium transients in aequorin-injected frog cardiac muscle. Nature 1978; 273: 509-513
31. ++ transients in cat papillary muscle. Can J Physiol Pharmacol 1982; 60: 524-528
32. Perreault CL, Shannon RP, Komamura K, Vatner SF, Morgan JP: Abnormalities in intracellular calcium regulation and contractile function in myocardium from dogs with pacing- induced heart failure. J Clin Invest 1992; 89: 932-938
33. Gwathmey JK, Slawsky MT, Hajjar RJ, Morgan JP: Role of intracellular calcium handling in force-interval relationship of human ventricular myocardium. J Clin Invest 1990; 85: 1599-1613
34. Gwathmey JK, Copelas L, MacKinnon R: Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 1987; 61: 70-76
35. Gundersen T, Grottum P, Pedersen T, Kjekshus JK: Effect of timolol on mortality and reinfarction after acute myocardial infarction: prognostic importance of heart rate at rest. Am J Cordiol 1986; 58: 20-24
36. Feldman MD, Gwathmey JK, Phillips P, Schoen F, Morgan JP: Reversal of the force-frequency relationship in working myocardium from patients with end-stage heart failure. J Appl Cardiol 1988; 3: 273-283
37. Asanoi H, Ishizaka S, Joho S, Kameyama T, Sasayama S: Altered inotropic and lusitropic responses to heart rate in conscious dogs with tachycardia-induced heart failure. J Am Coll Cardiol 1996; 27: 728-735
38. Grossman W: Diastolic dysfunction in congestive heart failure. N Engl J Med 1991; 325: 1557-1564
39. Grossman W, McLaurin LP, Rolett E: Alterations in left ventricular relaxation and diastolic compliance in congestive cardiomyopathy. Cardiovasc Res 1979; 13: 514-522
40. Weber KT, Janicki JS: Interdependence of cardiac function, coronary flow, and oxygen extraction. Am J Physiol 1978; 235: H784-H793
41. Boerth RC, Covell JW, Ross J Jr: Increased myocardial oxygen consumption and contractile state associated with increased heart rate in dogs. Circ Res 1969; 24: 725-734
42. Little WC, Cheng CP: Left ventriculo-arterial coupling in conscious dogs. Am J Physiol 1991; 26: H70-H79
43. Asanoi K, Sasayama S, Kameyama T: Ventriculoarterial coupling in normal and failing heart in humans. Circ Res 1989; 65: 483-493
44. Takaoka H, Takeuchi M, Odake M, Hayashi Y, Mori M, Hata K, et al: Comparison of the effects on arterial-ventricular coupling between phosphodiesterase inhibitor and dobutamine in the diseased human heart. J Am Coll Cardiol 1993; 22: 598-606
45. Nul DR, Doval HC, Grancelli HO: Heart rate is a marker of amiodarone mortality reduction in severe heart failure. J Am Coll Cardiol 1997; 29: 1199-1205
46. Higashiyama A, Watkins MW, Chen Z, LeWinter MM: Preload does not influence non-mechanical O2 consumption in isolated rabbit heart. Am J Physiol 1994; 266: H1047-H1054
47. Suga H, Hisano R, Hirata H, Hayashi T, Ninomiya I: Mechanism of higher oxygen consumption rate: pressure-loaded versus volume-loaded heart. Am J Physiol 1982; 242: H942-H948
48. Asanoi H, Ishizaka S, Kameyama T, Sasayama S: Neural moduration of ventriculoarterial coupling in conscious dogs. Am J Physiol 1994; 266: H741-H748
49. Van Bogaert PP, Goethals M, Simoens C: Use- and frequency-dependent blockade by UL-FS 49 of the If pacemaker current in sheep cardiac Purkinje fibers. Eur J Pharmacol 1990; 187: 241-256
50. Katz A: Cellular mechanism in congestive heart. Am J Cardiol 1988; 62: 3A-8A
51. Katz A: Cardiomyopathy of overload: a major determinant of prognosis in congestive heart failure. N Engl J Med 1990; 322: 100-110
52. Liao R, Nascimben L, Friedrich J, Gwathmey JK, Ingwall JS: Decreased energy reserve in an animal model of dilated cardiomyopathy. Relationship to contractile performance. Circ Res 1996; 78: 893-902
53. Indolfi C, Guth BD, Miura T, Miyazaki S, Schultz R, Ross J Jr: Mechanisms of improved ischemic regional dysfunction by bradycardia: studies of UL-FS 49 in swine. Circulation 1989; 80: 983-993