메뉴 건너뛰기




Volumn 40, Issue 7, 2006, Pages 741-752

Radical scavenging and NO-releasing properties of selected b-adrenoreceptor antagonists

Author keywords

Carvedilol; Nebivolol; NO release; Radical scavenging

Indexed keywords

BENZOPYRAN DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAZOLE DERIVATIVE; CARVEDILOL; EPOXIDE; ETHANOLAMINE DERIVATIVE; METHYLAMINE; NEBIVOLOL; NITRIC OXIDE; PROPANOLAMINE DERIVATIVE; PROPYLENE OXIDE; SCAVENGER;

EID: 37349088295     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760600690329     Document Type: Article
Times cited : (17)

References (66)
  • 5
  • 6
    • 0036135805 scopus 로고    scopus 로고
    • Nebivolol: Endothelium-mediated vasodilating effect
    • Ritter JM. Nebivolol: Endothelium-mediated vasodilating effect. J Cardiovasc Pharmacol 2001;38(Suppl 3):S13-S16 (Pubitemid 34026334)
    • (2002) Journal of Cardiovascular Pharmacology , vol.38 , Issue.SUPPL. 3
    • Ritter, J.M.1
  • 7
    • 0035979349 scopus 로고    scopus 로고
    • Nebivolol reverses endothelial dysfunction in essential hypertention: A randomized, double crossover study
    • Tzemos N, Lim PO, MacDonald TM. Nebivolol reverses endothelial dysfunction in essential hypertension: A randomized, double-blind, crossover study. Circulation 2001;104:511-514 (Pubitemid 32738117)
    • (2001) Circulation , vol.104 , Issue.5 , pp. 511-514
    • Tzemos, N.1    Lim, P.O.2    MacDonald, T.M.3
  • 8
  • 10
    • 0033766282 scopus 로고    scopus 로고
    • Carvedilol improves endothelium-dependent dilatation in patients with coronary artery disease
    • Matsuda Y, Akita H, Terashima M, Shiga N, Kanazawa K, Yokoyama M. Carvedilol improves endothelium-dependent dilatation in patients with coronary artery disease. Am Heart J 2000;140:753-759
    • (2000) Am Heart J , vol.140 , pp. 753-759
    • Matsuda, Y.1    Akita, H.2    Terashima, M.3    Shiga, N.4    Kanazawa, K.5    Yokoyama, M.6
  • 11
    • 0037904408 scopus 로고    scopus 로고
    • Third-generation β-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: A novel mechanism for antihypertensive action
    • Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, Jankowski M, Martyniec L, Angielski S, Malinski T. Thirdgeneration beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: A novel mechanism for antihypertensive action. Circulation 2003;107:2747-2752 (Pubitemid 36667251)
    • (2003) Circulation , vol.107 , Issue.21 , pp. 2747-2752
    • Kalinowski, L.1    Dobrucki, L.W.2    Szczepanska-Konkel, M.3    Jankowski, M.4    Martyniec, L.5    Angielski, S.6    Malinski, T.7
  • 16
    • 0038171300 scopus 로고    scopus 로고
    • Carvedilol attenuates CPB-induced apoptosis in dog heart: Regulation of Fas/FasL and caspase-3 pathway
    • Zhang S, Sun Z, Liu L, Hasichaonu. Carvedilol attenuates CPB-induced apoptosis in dog heart: Regulation of Fas/FasL and caspase-3 pathway. Chin Med J (Engl) 2003; 116:761-766 (Pubitemid 36701866)
    • (2003) Chinese Medical Journal , vol.116 , Issue.5 , pp. 761-766
    • Zhang, S.1    Sun, Z.2    Liu, L.3    Hasichaonu, A.4
  • 17
    • 0033038384 scopus 로고    scopus 로고
    • Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: Protective effects of nebivolol
    • DOI 10.1016/S0014-2999(98)00907-8, PII S0014299998009078
    • Janssen PM, Zeitz O, Hasenfuss G. Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: Protective effects of nebivolol. Eur J Pharmacol 1999;366:223-232 (Pubitemid 29080786)
    • (1999) European Journal of Pharmacology , vol.366 , Issue.2-3 , pp. 223-232
    • Janssen, P.M.L.1    Zeitz, O.2    Hasenfuss, G.3
  • 18
    • 0036135328 scopus 로고    scopus 로고
    • Protective role of nebivolol in hydroxyl radical induced injury
    • Janssen PM, ZeitzO, Rahman A. Protective role of nebivolol in hydroxyl radical induced injury. J Cardiovasc Pharmacol 2001;38(Suppl 3):S17-S23
    • (2001) J Cardiovasc Pharmacol , vol.38 , Issue.SUPPL. 3
    • Janssen, P.M.1    Zeitz, O.2    Rahman, A.3
  • 19
    • 0033609455 scopus 로고    scopus 로고
    • Effect of β-blockers on free radical-induced cardiac contractile dysfunction
    • Flesch M, Maack C, Cremers B, Bäumer AT, Südkamp M, Böhm M. Effect of ß-blockers on free radical-induced cardiac contractile dysfunction. Circulation 1999;100:346-353 (Pubitemid 29362403)
    • (1999) Circulation , vol.100 , Issue.4 , pp. 346-353
    • Flesch, M.1    Maack, C.2    Cremers, B.3    Baumer, A.T.4    Sudkamp, M.5    Bohm, M.6
  • 20
    • 0029036277 scopus 로고
    • Protective effects of b-blockers against 2,20-azobis(2-amidinopropane)- dihydrochlorideinduced damage
    • Miura T, Muraoka S, Ogiso T. Protective effects of b-blockers against 2,20-azobis(2-amidinopropane)-dihydrochlorideinduced damage. Chem Biol Inter 1995;97:25-35
    • (1995) Chem Biol Inter , vol.97 , pp. 25-35
    • Miura, T.1    Muraoka, S.2    Ogiso, T.3
  • 21
    • 0029092047 scopus 로고
    • Carvedilol, a new beta-adrenoreceptor blocker antihypertensive drug, protects against free-radical-induced endothelial dysfunction
    • Lopez BL, Christopher TA, Yue TL, Ruffolo R, Feuerstein GZ, Ma XL. Carvedilol, a new beta-adrenoreceptor blocker antihypertensive drug, protects against free-radical-induced endothelial dysfunction. Pharmacol 1995;51:165-173
    • (1995) Pharmacol , vol.51 , pp. 165-173
    • Lopez, B.L.1    Christopher, T.A.2    Yue, T.L.3    Ruffolo, R.4    Feuerstein, G.Z.5    Ma, X.L.6
  • 22
    • 0028914187 scopus 로고
    • Carvedilol, a new beta-adrenoreceptor blocker, vasodilator and free-radical scavenger, exerts an anti-shock and endothelial protective effect in rat splanchnic ischemia and reperfusion
    • ChristopherTA, Lopez BL,Yue TL,Feuerstein GZ, Ruffolo Jr, RR, Ma XL. Carvedilol, a new beta-adrenoreceptor blocker, vasodilator and free-radical scavenger, exerts an anti-shock and endothelial protective effect in rat splanchnic ischemia and reperfusion. J Pharmacol Exp Ther 1995;273:64-71
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 64-71
    • Christopher, T.A.1    Lopez, B.L.2    Yue, T.L.3    Feuerstein, G.Z.4    Ruffolo Jr., R.R.5    Ma, X.L.6
  • 24
    • 0026533584 scopus 로고
    • Carvedilol, a new beta-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils
    • Yue TL, McKenna PJ, Ruffolo RP, Feuerstein GZ. Carvedilol, a new beta-adrenoceptor antagonist and vasodilator antihypertensive drug, inhibits superoxide release from human neutrophils. Eur J Pharmacol 1992;214:277-280
    • (1992) Eur J Pharmacol , vol.214 , pp. 277-280
    • Yue, T.L.1    McKenna, P.J.2    Ruffolo, R.P.3    Feuerstein, G.Z.4
  • 25
    • 0025812485 scopus 로고
    • Free radical scavenging and inhibition of lipid peroxidation by betablockers and by agents that interfere with calcium metabolism. A physiologically-significant process?
    • Aruoma OI, Smith C, Cecchini R, Evans PJ, Halliwell B. Free radical scavenging and inhibition of lipid peroxidation by betablockers and by agents that interfere with calcium metabolism. A physiologically-significant process? Biochem Pharmacol 1991;42:735-743
    • (1991) Biochem Pharmacol , vol.42 , pp. 735-743
    • Aruoma, O.I.1    Smith, C.2    Cecchini, R.3    Evans, P.J.4    Halliwell, B.5
  • 27
    • 0032431627 scopus 로고    scopus 로고
    • Carvedilol inhibition of lipid peroxidation. A new antioxidative mechanism
    • DOI 10.1080/10715769800300421
    • Tadolini B, Franconi F. Carvedilol inhibition of lipid peroxidation. A new antioxidative mechanism. Free Rad Res 1998;29:377-387 (Pubitemid 29047995)
    • (1998) Free Radical Research , vol.29 , Issue.5 , pp. 377-387
    • Tadolini, B.1    Franconi, F.2
  • 28
    • 0033952160 scopus 로고    scopus 로고
    • No effect of carvedilol on nitric oxide generation in phagocytes but modulation of production of superoxide ions
    • DOI 10.1016/S0006-2952(99)00393-7, PII S0006295299003937
    • Asbrink S, Zickert A, Bratt J, Gyllenhammar H, Palmblad J. No effect of carvedilol on nitric oxide generation in phagocytes but modulation of production of superoxide ions. Biochem Pharmacol 2000;59:1007-1013 (Pubitemid 30110817)
    • (2000) Biochemical Pharmacology , vol.59 , Issue.8 , pp. 1007-1013
    • Asbrink, S.1    Zickert, A.2    Bratt, J.3    Gyllenhammar, H.4    Palmblad, J.5
  • 30
    • 0033951439 scopus 로고    scopus 로고
    • Antioxidant action of the antihypertensive drug, carvedilol, against lipid peroxidation
    • DOI 10.1016/S0006-2952(99)00417-7, PII S0006295299004177
    • Noguchi N, Nishino K, Niki E. Antioxidant action of the antihypertensive drug, carvedilol, against lipid peroxidation. Biochem Pharmacol 2000;59:1069-1076 (Pubitemid 30110499)
    • (2000) Biochemical Pharmacology , vol.59 , Issue.9 , pp. 1069-1076
    • Noguchi, N.1    Nishino, K.2    Niki, E.3
  • 31
    • 0027441853 scopus 로고
    • Carvedilol, a new antihypertensive agent, prevents lipid peroxidation and oxidative injury to endothelial cells
    • Yue TL, McKenna PJ, Gu JL, Cheng HY, Ruffolo Jr, RR, Feuerstein GZ. Carvedilol, a new antihypertensive agent, prevents lipid peroxidation and oxidative injury to endothelial cells. Hypertens 1993;22:922-928 (Pubitemid 23358101)
    • (1993) Hypertension , vol.22 , Issue.6 , pp. 922-928
    • Yue, T.L.1    Mckenna, P.J.2    Gu, J.L.3    Cheng, H.Y.4    Ruffolo Jr., R.R.5    Feuerstein, G.Z.6
  • 32
    • 0028288724 scopus 로고
    • A potent antioxidant, SB209995, inhibits oxygen-radical-mediated lipid peroxidation and cytotoxicity
    • Feurestein GZ, Yue TL. A potent antioxidant, SB209995, inhibits oxygen-radical-mediated lipid peroxidation and cytotoxicity. Pharmacol 1994;48:385-391
    • (1994) Pharmacol , vol.48 , pp. 385-391
    • Feurestein, G.Z.1    Yue, T.L.2
  • 33
    • 0026462553 scopus 로고
    • Carvedilol, a new antihypertensive, prevents oxidation of human low density lipoprotein by macrophages and copper
    • Yue TL, McKenna PJ, Lysko PG, Ruffolo Jr, RR, Feuerstein GZ. Carvedilol, a new antihypertensive, prevents oxidation of human low density lipoprotein by macrophages and copper. Atheroscler 1992;97:209-216
    • (1992) Atheroscler , vol.97 , pp. 209-216
    • Yue, T.L.1    McKenna, P.J.2    Lysko, P.G.3    Ruffolo Jr., R.R.4    Feuerstein, G.Z.5
  • 34
    • 0035879973 scopus 로고    scopus 로고
    • Radical-scavenging and iron-chelating properties of carvedilol, an antihypertensive drug with antioxidative activity
    • DOI 10.1016/S0006-2952(01)00651-7, PII S0006295201006517
    • Oettl K, Greilberger J, Zangger K, Haslinger E, Reibnegger G, Juergens G. Radical-scavenging and iron-chelating properties of carvedilol, an antihypertensive drug with antioxidative activity. Biochem Pharmacol 2001;62:241-248 (Pubitemid 32522945)
    • (2001) Biochemical Pharmacology , vol.62 , Issue.2 , pp. 241-248
    • Oettl, K.1    Greilberger, J.2    Zangger, K.3    Haslinger, E.4    Reibnegger, G.5    Jurgens, G.6
  • 37
    • 33847087730 scopus 로고
    • Yield for the scavenging of hydroxyl radicals in the radiolysis of nitrous oxide-saturated aqueous solutions
    • Schuler RH, Patterson LK, Janata E. Yield for the scavenging of hydroxyl radicals in the radiolysis of nitrous oxide-saturated aqueous solutions. J Phys Chem 1980;84:2088-2089
    • (1980) J Phys Chem , vol.84 , pp. 2088-2089
    • Schuler, R.H.1    Patterson, L.K.2    Janata, E.3
  • 39
    • 50749133853 scopus 로고
    • Pulse radiolysis system based on ELU-6e linac-II. Development and upgrading the system
    • Karolczak S, Hodyr K, Po?owiń ski M. Pulse radiolysis system based on ELU-6e linac-II. Development and upgrading the system. Radiat Phys Chem 1992;39:1-5
    • (1992) Radiat Phys Chem , vol.39 , pp. 1-5
    • Karolczak, S.1    Hodyr, K.2    Poowiń Ski, M.3
  • 40
    • 84918833988 scopus 로고
    • Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution
    • Buxton GV, Greenstock CL, Helman WP, Ross AB. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution. J Phys Chem Ref Data 1988;17:513-886
    • (1988) J Phys Chem Ref Data , vol.17 , pp. 513-886
    • Buxton, G.V.1    Greenstock, C.L.2    Helman, W.P.3    Ross, A.B.4
  • 41
    • 84889557831 scopus 로고
    • Rate constants for reactions of inorganic radicals in aqueous solutions
    • Neta P, Huie RE, Ross AB. Rate constants for reactions of inorganic radicals in aqueous solutions. J Phys Chem Ref Data 1988;17:1027-1284
    • (1988) J Phys Chem Ref Data , vol.17 , pp. 1027-1284
    • Neta, P.1    Huie, R.E.2    Ross, A.B.3
  • 42
    • 84872846883 scopus 로고
    • Reduction potentials of one-electron couples involving free radicals in aqueous solution
    • Wardman P. Reduction potentials of one-electron couples involving free radicals in aqueous solution. J Phys Chem Ref Data 1989;18:1637-1755
    • (1989) J Phys Chem Ref Data , vol.18 , pp. 1637-1755
    • Wardman, P.1
  • 43
    • 0000391482 scopus 로고
    • Reactivity of the CCl3OOz radical. Evidence for a first-order transformation
    • Shen X, Lind J, Eriksen TE, Merenyi G. Reactivity of the CCl3OOz radical. Evidence for a first-order transformation. J Phys Chem 1989;93:553-557
    • (1989) J Phys Chem , vol.93 , pp. 553-557
    • Shen, X.1    Lind, J.2    Eriksen, T.E.3    Merenyi, G.4
  • 44
    • 0000877581 scopus 로고
    • Rate constants for reduction of substituted methylperoxyl radicals by ascorbate ions and N, N, N0, N0-teramethyl-p-phenylenediamine
    • Neta P, Huie RE, Mosseri S, Shastri LV, Mittal JP, Maruthamuthu P, Steenken S. Rate constants for reduction of substituted methylperoxyl radicals by ascorbate ions and N, N, N0, N0-teramethyl-p-phenylenediamine. J Phys Chem 1989;93:4099-4104
    • (1989) J Phys Chem , vol.93 , pp. 4099-4104
    • Neta, P.1    Huie, R.E.2    Mosseri, S.3    Shastri, L.V.4    Mittal, J.P.5    Maruthamuthu, P.6    Steenken, S.7
  • 45
    • 0000189651 scopus 로고
    • Density-functional thermochemistry. III. The role of exact exchange
    • Becke AD. Density-functional thermochemistry. III. The role of exact exchange. J Chem Phys 1993;98:5648-5652
    • (1993) J Chem Phys , vol.98 , pp. 5648-5652
    • Becke, A.D.1
  • 46
    • 0345491105 scopus 로고
    • Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density
    • Lee C, Yang W, Parr RG. Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Phys Rev B 1988;37:785-789
    • (1988) Phys Rev B , vol.37 , pp. 785-789
    • Lee, C.1    Yang, W.2    Parr, R.G.3
  • 48
    • 0343986324 scopus 로고    scopus 로고
    • Reversal of the postischaemic suppression of coronary function in perfused guinea pig heart by ischaemic preconditioning
    • Chlopicki S, Lomnicka M, Gryglewski RJ. Reversal of the postischaemic suppression of coronary function in perfused guinea pig heart by ischaemic preconditioning. J Physiol Pharmacol 1999;50:605-615 (Pubitemid 30022139)
    • (1999) Journal of Physiology and Pharmacology , vol.50 , Issue.4 , pp. 605-615
    • Chlopicki, S.1    Lomnicka, M.2    Gryglewski, R.J.3
  • 52
    • 0001143033 scopus 로고
    • Pulse radiolysis studies concerning the reactions of hydrogen abstraction from tetraalkylammonium cations
    • Bobrowski K. Pulse radiolysis studies concerning the reactions of hydrogen abstraction from tetraalkylammonium cations. J Phys Chem 1980;84:3524-3529
    • (1980) J Phys Chem , vol.84 , pp. 3524-3529
    • Bobrowski, K.1
  • 53
    • 84874448185 scopus 로고
    • Electronic absorption spectra of radical ions
    • Shida T. Electronic absorption spectra of radical ions. Amsterdam: Elsevier; 1988
    • (1988) Amsterdam: Elsevier
    • Shida, T.1
  • 54
    • 0001565451 scopus 로고
    • Electron and hydrogen atom attachment to aromatic carbonyl compounds in aqueous solution. Absorption spectra and dissociation constants of ketyl radicals
    • Hayon E, Ibata T, Lichtin NN, Simic M. Electron and hydrogen atom attachment to aromatic carbonyl compounds in aqueous solution. Absorption spectra and dissociation constants of ketyl radicals. J Phys Chem 1972;76:2072-2078
    • (1972) J Phys Chem , vol.76 , pp. 2072-2078
    • Hayon, E.1    Ibata, T.2    Lichtin, N.N.3    Simic, M.4
  • 55
    • 0029907656 scopus 로고    scopus 로고
    • A hydroxylated analog of the β-adrenoceptor antagonist, carvedilol, affords exceptional antioxidant protection to postischemic rat hearts
    • DOI 10.1016/0891-5849(96)00184-0
    • Kramer JH, Weglicki WB. A hydroxylated analog of the betaadrenoceptor antagonist, carvedilol, affords exceptional anti-oxidant protection to postischemic rat hearts. Free Radic Biol Med 1996;21:813-825 (Pubitemid 26365277)
    • (1996) Free Radical Biology and Medicine , vol.21 , Issue.6 , pp. 813-825
    • Kramer, J.H.1    Weglicki, W.B.2
  • 56
    • 0014627398 scopus 로고
    • Pulse-and gamma-radiolysis of aqueous solutions of tryptophan
    • Armstrong RC, Swallow AJ. Pulse-and gamma-radiolysis of aqueous solutions of tryptophan. Radiat Res 1969;40:563-579
    • (1969) Radiat Res , vol.40 , pp. 563-579
    • Armstrong, R.C.1    Swallow, A.J.2
  • 57
    • 0002321377 scopus 로고
    • Radiation chemistry of aqueous solutions of indole and its derivatives
    • Iddon B, Philips GO, Robbins KE. Radiation chemistry of aqueous solutions of indole and its derivatives. J Chem Soc B 1971;1887-1892
    • (1971) J Chem Soc B , pp. 1887-1892
    • Iddon, B.1    Philips, G.O.2    Robbins, K.E.3
  • 58
    • 0016851391 scopus 로고
    • Excited state chemistry of aromatic amino acids and related peptides. III. Tryptophan
    • Bent DV, Hayon E. Excited state chemistry of aromatic amino acids and related peptides. III. Tryptophan. J Am Chem Soc 1975;97:2612-2619
    • (1975) J Am Chem Soc , vol.97 , pp. 2612-2619
    • Bent, D.V.1    Hayon, E.2
  • 59
    • 0011980712 scopus 로고
    • Flash photolysis of N-acetyl-L-tryptophanamide, acid-base equilibrium of the radical transients
    • Evans RF, Ghiron CA, VolkertWA,Kuntz RR. Flash photolysis of N-acetyl-L-tryptophanamide, acid-base equilibrium of the radical transients. Chem Phys Lett 1976;42:43-45
    • (1976) Chem Phys Lett , vol.42 , pp. 43-45
    • Evans, R.F.1    Ghiron, C.A.2    Volkert, W.A.3    Kuntz, R.R.4
  • 60
    • 37049104108 scopus 로고
    • Mechanism of tryptophan oxidation by some inorganic radical-anions: A pulse radiolysis study
    • Posener MI, Adams GE, Wardman P, Cundall RB. Mechanism of tryptophan oxidation by some inorganic radical-anions: A pulse radiolysis study. J Chem Soc Faraday Trans I 1976;72:2231-2239
    • (1976) J Chem Soc Faraday Trans i , vol.72 , pp. 2231-2239
    • Posener, M.I.1    Adams, G.E.2    Wardman, P.3    Cundall, R.B.4
  • 61
    • 0030266386 scopus 로고    scopus 로고
    • Peroxyl radical scavenging activity of the antihypertensive drug carvedilol
    • Arouma OI. Peroxyl radical scavenging activity of the antihypertensive drug carvedilol. Toxicol in vitro 1996;10:625-629
    • (1996) Toxicol in Vitro , vol.10 , pp. 625-629
    • Arouma, O.I.1
  • 63
    • 0031767559 scopus 로고    scopus 로고
    • Antihypertensive therapy and insulin sensitivity: Do we have to redefine the role of beta-blocking agents?
    • Jacob S, Rett K, Henriksen EJ. Antihypertensive therapy and insulin sensitivity: Do we have to redefine the role of beta-blocking agents?AmJ Hypertens 1998;11:1258-1265
    • (1998) AmJ Hypertens , vol.11 , pp. 1258-1265
    • Jacob, S.1    Rett, K.2    Henriksen, E.J.3
  • 64
    • 0034910780 scopus 로고    scopus 로고
    • Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients
    • DOI 10.1097/00004872-200108000-00011
    • Poirier L, Cleroux J, Nadeau A, Lacourciere Y. Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients. J Hypertens 2001;19: 1429-1435 (Pubitemid 32730460)
    • (2001) Journal of Hypertension , vol.19 , Issue.8 , pp. 1429-1435
    • Poirier, L.1    Cleroux, J.2    Nadeau, A.3    Lacourciere, Y.4
  • 65
    • 0037159292 scopus 로고    scopus 로고
    • Carvedilol prospective randomized cumulative survival (COPERNICUS) trial: Carvedilol as the sun and center of the β-blocker world?
    • DOI 10.1161/01.CIR.0000038702.35084.D6
    • Wollert KC, Drexler H. Carvedilol prospective randomized cumulative survival (COPERNICUS) trial: Carvedilol as the sun and center of the beta-blocker world? Circulation 2002;106:2164-2166 (Pubitemid 35222205)
    • (2002) Circulation , vol.106 , Issue.17 , pp. 2164-2166
    • Wollert, K.C.1    Drexler, H.2
  • 66
    • 0242609837 scopus 로고    scopus 로고
    • Celiprolol Activates eNOS through the PI3K-Akt Pathway and Inhibits VCAM-1 Via NF-κB Induced by Oxidative Stress
    • DOI 10.1161/01.HYP.0000097547.35570.70
    • Kobayashi N, Mita S, Yoshida K, Honda T, Kobayashi T, Hara K, Nakano S, Tsubokou Y, Matsuoka H. Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 via NF-kappaB induced by oxidative stress. Hypertens 2003;42:1004-1013. (Pubitemid 37413745)
    • (2003) Hypertension , vol.42 , Issue.5 , pp. 1004-1013
    • Kobayashi, N.1    Mita, S.-I.2    Yoshida, K.3    Honda, T.4    Kobayashi, T.5    Hara, K.6    Nakano, S.7    Tsubokou, Y.8    Matsuoka, H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.