Estimating the use of veterinary medicines in the European union

Regulatory Toxicology and Pharmacology

Volumn 50, Issue 1, 2008, Pages 59-65

  Kools, Stefan A E ^a   Moltmann, Johann F ^a   Knacker, Thomas ^a  

^a ECT OEKOTOXIKOLOGIE GMBH   (Germany)

Author keywords

Antibiotics; Antiparasitics; Environmental risk assessment; Europe; Hormones; Prioritisation methodology; Use volumes; Veterinary pharmaceuticals

Indexed keywords

ANTIBIOTIC AGENT; ANTIPARASITIC AGENT; HORMONE DERIVATIVE;

ARTICLE; DIGESTIVE SYSTEM; DRUG INDUSTRY; ENVIRONMENTAL FACTOR; EUROPE; EXPLORATORY RESEARCH; FOOD INDUSTRY; HEALTH CARE QUALITY; HEMATOPOIETIC SYSTEM; HUMAN; INFORMATION PROCESSING; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; VETERINARY MEDICINE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIPARASITIC AGENTS; EUROPEAN UNION; HORMONES; MEAT; VETERINARY DRUGS;

EID: 37349083893     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2007.06.003     Document Type: Article

References (38)

1. Aarestrup F.M. Veterinary drug usage and antimicrobial resistance in bacteria of animal origin. Basic Clin. Pharmcol. Toxicol. 96 (2005) 271-281
2. Boxall A.B.A., Fogg L.A., Blackwell P.A., Kay P., Pemberton E.J., and Croxford A. veterinary medicines environment. Rev. Environ. Contam. Toxicol. 180 (2004) 1-91
3. Boxall, A.B.A., Fogg, L.A., Blackwell, P.A., Kay, P., Pemberton, E.J., 2002. Review of Veterinary Medicines in the Environment. R&D Technical Report P6-012/8/TR for Environment Agency, Cranfield Centre for EcoChemistry, Cranfield University, Shardlow Hall, Shardlow, Derby, United Kingdom.
4. Capelton A., Courage C., Rumsby P., Stutt E., Boxall A., and Levy L. Prioritising veterinary medicines according to their potential indirect human exposure and toxicity profile. Toxicol. Lett. 163 3 (2006) 213-223
5. Christensen F.M. Pharmaceuticals in the Environment - a Human Risk?. Regul. Toxicol. Pharmacol. 28 3 (1998) 212-221
6. DANMAP, 2004. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark. ISSN 1600-2032.
7. Dzialowski E.M., Turner P.K., and Brooks B.W. Physiological and reproductive effects of beta adrenergic receptor antagonists in Daphnia magna. Arch. Environ. Contamination Toxicol. 50 (2006) 503-510
8. EC, 2001. Directive 2001/82/EC of the European Parliament and of the Council of 6 November 2001 on the community code relating to veterinary medicinal products. Official Journal of the European Community. L, 311, as amended by Directive 2004/28/EC of the European Parliament and the Council. Official Journal of the European Communities, L 136, 58-84.
9. EC, 2004. Regulation (EC) No 726/2004 of the European Parliament and of the Council of 31 March 2004 laying down Community procedures for the authorisation and supervision of medicinal products for human and veterinary use and establishing a European Medicines Agency Official Journal of the European Union. L136, 1-33.
10. EMEA, 1999. Antibiotic resistance in the European Union associated with therapeutic use of veterinary medicines, EMEA/CVMP/342/99-corr-Final. London, United Kingdom.
11. EMEA, 2006. Guideline on Environmental Impact Assessment for Veterinary Medicinal Products in Support of the VICH Guidelines GL 6 and GL 38. (Draft Veterinary TGD). Committee for Medicinal Products for Veterinary Use (CVMP); London, 18 January 2006; Doc. Ref. EMEA/CVMP/ERA/ 418282/2005-CONSULTATION; p. 59.
12. FINRES-Vet, 2004. Finnish Veterinary Antimicrobial Resistance Monitoring and Consumption of Antimicrobial Agents. National Veterinary and Food Research Institute (EELA), Helsinki, Finland, ISSN 1458-6878.
13. Greko, C., 2005. Anti-infective usage in animals - a risk for human health? Abstracts from Euroconference Mastering anti-infective therapies. Paris (France) October 20-21, 2005. http://www.pasteur.fr/applications/euroconf/antiinfectionstherapies/5_Greko_abstract_pdf.
14. Halling-Sorensen B., Nielsen S.N., Lanzky P.F., Ingerslev F., Lutzhoft H.C.H., and Jorgensen S.E. Occurrence, fate and effects of pharmaceutical substances in the environment - A review. Chemosphere 36 (1998) 357-394
15. Halling-Sorensen, B., Nielsen, S.N., Jensen, J., 2002. Environmental Project No. 659 - Environmental assessment of veterinary medicinal products in Denmark. Danish Environmental Protection Agency.
16. IEH, 2004. A review of prioritisation methodologies for screening chemicals with potential human health effects as a result of low-level exposure (Web Report W13). MRC Institute for Environment and Health, Leicester, UK (available at http://www.le.ac.uk/ieh/).
17. IFAH, 2005. Facts and figures about the European Animal Health Industry. IFAH Europe - representing the European Animal Health Industry, Brussels, Belgium.
18. Klein-Goedicke, J., 2004. Arzneimitteleinsatz in der intensiven Tierhaltung. UBA-Symposium - Anzneimittel in der Umwelt, Berlin, Germany 29./30.09.2004.
19. KTBL, 2005. Schwermetalle und Tierarzneimittel in Wirtschaftdüngern. Kuratorium für Technik und Bauwesen in der Landwirtschaft e. V., Darmstadt, Germany.
20. Kümmerer K. Pharmaceuticals in the environment. 2nd ed. (2004), Springer-Verlag, Berlin Heidelberg, Germany
21. Kümmerer K. Resistance in the environment. J. Antimicro. Chemother. 54 (2004) 311-320
22. LUA, 2001. Band 29 - Tierarzneimittel in der Umwelt - Erhebung von Tierarzneimittelmengen im Land Brandenburg für den Zeitraum von Juli 1998 bis Juni 1999. Landesumweltamt Brandenburg (LUA), Potsdam, Germany.
23. Lumaret J.P., and Errouissi F. Use of anthelmintics in herbivores and evaluation of risks for the non target fauna of pastures. Veterinary Res. 33 (2002) 547-562
24. MARAN, 2004. Monitoring of antimicrobial resistance and antibiotic usage in animals in The Netherlands in 2004. Werkgroep Antibioticumbeleid, The Hague, The Netherlands.
25. Moulin, G., Roux, S., 2005. Suivi des ventes de médicaments vétérinaires contenant des antibiotiques en France en 2004. Agence Nationale du Médicament Vétérinaire (ANMV-AFSSA), Fougères cedex, France. http://www.afssa.fr/ftp/afssa/34215-34216.pdf.
26. Oaks J.L., Gilbert M., Virani M.Z., Watson R.T., Meteyer C.U., Rideout B.A., Shivaprasad H.L., Ahmed S., Chaudhry M.J.I., Arshad M., Mahmood S., Ali A., and Khan A.A. Diclofenac residues as the cause of population decline of vultures in Pakistan. Nature 427 (2004) 630-633
27. Sanderson H., Johnson D.J., Reitsma T., Brain R.A., Wilson C.J., and Solomon K.R. Ranking and prioritization of environmental risks of pharmaceuticals in surface waters. Regul. Toxicol. Pharmacol. 39 (2004) 158-183
28. Sarmah A.K., Meyer M.T., and Boxall A.B. A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65 (2006) 725-759
29. Schneidereit, M., 2004. Aktuelle studie: Verbrauchsmengen von Tierarzneimittel. UBA-Symposium - Anzneimittel in der Umwelt. http://www.bft-online.de/, Berlin, Germany 29./30.09.2004.
30. Stege H., Bager F., Jacobsen E., and Thougaard A. VETSTAT - the Danish system for surveillance of the veterinary use of drugs for production animals. Preven. Veterinary Med. 57 (2003) 105-115
31. SVARM, 2005. SVARM-2004, Swedish Veterinary Antimicrobial Resistance Monitoring. The National Veterinary Institute (SVA), Uppsala, Sweden, www.sva.se, ISSN 1650-6332.
32. Szprengier-Juszkiewicz T. Veterinary drugs - principles of environmental risk assessment. Medycyna Weterynaryjna 58 (2002) 169-174
33. In: Ternes A.T., and Joss A. (Eds). Human Pharmaceuticals, Hormones and Fragrances The Challenge of Micropollutants in Urban Water Management (2006), IWA Publishing, London, United Kingdom
34. Thiele-Bruhn S. Pharmaceutical antibiotic compounds in soils - a review. Journal of Plant Nutrition and Soil Science-Zeitschrift Fur Pflanzenernahrung Und Bodenkunde. 166 (2003) 145-167
35. Thiele-Bruhn S., Mogk A., and Rostock D.F. Einsatz von Tierarzneimitteln zur Anwendung bei landwirtschaftlichen Nutztieren in Mecklenburg-Vorpommern. Berichte über Landwirtschaft 81 (2003) 374-391
36. VMD, 2005. Sales of antimicrobial products authorised for use as veterinary medicines, antiprotozoals, antifungals, growth promotors and coccidiostats, in the UK in 2004. Veterinary Medicines Directorate New Haw, Addlestone, Surrey, United Kingdom, http://www.vmd.gov.uk/.
37. Woodward K.N. Veterinary pharmacovigilance. Part 3. Adverse effects of veterinary medicinal products in animals and on the environment. J. Veterinary Pharmacol. Therapeutics 28 (2005) 171-184
38. Zuccato E., Castiglioni S., Fanelli R., Bagnati R., and Calamari D. Pharmaceuticals in the environment: changes in the presence and concentrations of pharmaceuticals for human use in Italy. In: Kümmerer K. (Ed). Pharmaceuticals in the environment. 2nd ed. (2004), Springer-Verlag, Berlin Heidelberg, Germany