The effect of paclitaxel on conjunctival wound healing: A pilot study

Journal of Glaucoma

Volumn 16, Issue 7, 2007, Pages 610-615

  Koz, Ozlem Gurbuz ^a,c   Ozhuy, Serife ^a   Tezel, Gaye Guler ^b   Karaman, Nazmiye ^b   Unlu, Nursen ^b   Yarangumeli, Alper ^a   Kural, Gulcan ^a  

^a ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c School of Pharmacy ^*  (Turkey)

Author keywords

Antimetabolite in glaucoma surgery; Carbopol hydrogel; Mitomycin C; Paclitaxel

Indexed keywords

CARBOMER; CELLULOSE; MITOMYCIN C; PACLITAXEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONJUNCTIVA DISEASE; CONTROLLED STUDY; CORNEA LIMBUS; DRUG EFFECT; EXPERIMENTAL RABBIT; EYE INFLAMMATION; EYE INJURY; HISTOPATHOLOGY; HYDROGEL; MALE; MICROSCOPY; NONHUMAN; OCULAR FIBROSIS; PRIORITY JOURNAL; RANDOMIZATION; SCLERA; SCORING SYSTEM; TISSUE FLAP; WOUND HEALING;

ACRYLIC RESINS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CONJUNCTIVA; DRUG CARRIERS; FIBROSIS; LEUKOCYTE COUNT; MALE; MITOMYCIN; NEUTROPHILS; PACLITAXEL; PILOT PROJECTS; RABBITS; SURGICAL FLAPS; WOUND HEALING;

EID: 37349068794     PISSN: 10570829     EISSN: None     Source Type: Journal    
DOI: 10.1097/IJG.0b013e31815c89b9     Document Type: Article

References (31)

1. Hitchings RA, Grierson I. Clinico pathological correlation in eyes with failed fistulizing surgery. Trans Ophthalmol Soc UK. 1983;103:84-88.
2. Addicks EM, Quigley HA, Green WR, et al. Histologic characteristics of filtering blebs in glaucomatous eyes. Arch Ophthalmol. 1983;101:795-798.
3. Atreides SP, Skuta GL, Reynolds AC. Wound healing modulation in glaucoma filtering surgery. Int Ophthalmol Clin. 2004;44:61-106.
4. Costa VP, Spaeth GL, Eiferman RA, et al. Wound healing modulation in glaucoma filtration surgery. Ophthalmic Surg. 1993;24:152-170.
5. Yamamoto T, Varani J, Soong HK, et al. Effects of 5-fluorouracil and mitomycin C on cultured rabbit subconjunctival fibroblasts. Ophthalmology. 1990;97:1202-1210.
6. Kitazawa Y, Kawase K, Matsushita H, et al. Trabeculectomy with mitomycin. A comparative study with fluorouracil. Arch Ophthalmol. 1991;109:1693-1698.
7. Crowson JG, Akbar AN, Constable PH, et al. Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts. Invest Ophthalmol Vis Sci. 1998;39:449-454.
8. Lee DA, Hersh P, Kersten D, et al. Complication of subconjunctival 5-fluorouracil following glaucoma filtering surgery. Ophthalmic Surg. 1987;18:187-190.
9. Jampel HD, Quigley HA, Kerrigan-Baumrind LA, et al. Glaucoma surgical outcomes study group. Risk factors for late-onset infection following glaucoma filtration surgery. Arch Ophthalmol. 2001;119:1001-1008.
10. Fannin LA, Schiffman JC, Budenz DL. Risk factors for hypotony maculopathy. Ophthalmology. 2003;110:1185-1191.
11. Von Hoff DD. The taxoids: same roots, different drugs. Semin Oncol. 1997;24:3-10.
12. Kohler DR, Goldspiel BR. Paclitaxel (taxol). Pharmacotherapy. 1994;14:3-34.
13. Joseph JP, Grierson I, Hitchings RA. Taxol, cytochalasin B and colchicine effects on fibroblast migration and contraction: a role in glaucoma filtration surgery? Curr Eye Res. 1989;8:203-215.
14. Jampel HD, Koya P, Leong K, et al. In vitro release of hydrophobic drugs from polyanhydride disks. Ophthalmic Surg. 1991;22:676-680.
15. Jampel HD, Thibault D, Leong KW, et al. Glaucoma filtration surgery in nonhuman primates using taxol and etoposide in polyanhydride carriers. Invest Ophthalmol Vis Sci. 1993;34:3076-3083.
16. Jampel HD, Moon JI. The effect of paclitaxel powder on glaucoma filtration surgery in rabbits. J Glaucoma. 1998;7:170-177.
17. Jampel HD, Leong KW, Dunkelburger GR, et al. Glaucoma filtration surgery in monkeys using 5-fluorouridine in polyanhydride disks. Arch Ophthalmol. 1990;108:430-435.
18. Schraermeyer U, Diestelhorst M, Bieker A, et al. Morphologic proof of the toxicity of mitomycin C on the ciliary body in relation to different application methods. Graefes Arch Clin Exp Ophthalmol. 1999;237:593-600.
19. Akyol N, Demir T, Cobanoglu B, et al. Ciliary body toxicity of cyclosporin A and octreotide acetate in rabbit eyes: a comparison with mitomycin C and 5-fluorouracil. Graefes Arch Clin Exp Ophthalmol. 2003;241:816-822.
20. Barry BW, Meyer MC. Proceedings: viscoelastic and continuous shear properties of Carbopol gels. J Pharm Pharmacol. 1974;26:129P-130P.
21. Yoo JW, Dharmala K, Lee CH. The physicodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system. Int J Pharm. 2006;309:139-145.
22. Shin SC, Kim HJ, Oh IJ, et al. Development of tretinoin gels for enhanced transdermal delivery. Eur J Pharm Biopharm. 2005;60:67-71.
23. Kao HJ, Lin HR, Lo YL, et al. Characterization of pilocarpine-loaded chitosan/Carbopol nanoparticles. J Pharm Pharmacol. 2006;58:179-186.
24. Cordeiro MF, Reichel MB, Gay JA, et al. Transforming growth factor-beta1, -beta2, and -beta3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring. Invest Ophthalmol Vis Sci. 1999;40:1975-1982.
25. Kruskal WH, Wallis WA. Use of ranks in one-criterion variance analysis. J Am Stat Assoc. 1952;47:583-621.
26. Desjardins DC, Parrish RK, Folberg R, et al. Wound healing after filtering surgery in owl monkeys. Arch Ophthalmol. 1986;104:1835-1839.
27. Madden JW, Morton D Jr, Peacock EE Jr. Contraction of experimental wounds. I. Inhibiting wound contraction by using a topical smooth muscle antagonist. Surgery. 1974;76:8-15.
28. Wani MC, Taylor HL, Wall ME, et al. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971;93:2325-2327.
29. Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by taxol. Nature. 1979;277:665-667.
30. van Bockxmeer FM, Martin CE, Thompson DE, et al. Taxol for the treatment of proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 1985;26:1140-1147.
31. Jampel HD. Effect of brief exposure to mitomycin C on viability and proliferation of cultured human Tenon's capsule fibroblasts. Ophthalmology. 1992;99:1471-1476.