Enzymatic release and macrolactonization of cryptophycins from a safety-catch solid support

Angewandte Chemie - International Edition

Volumn 46, Issue 48, 2007, Pages 9298-9300

  Seufert, Wolfgang ^a   Beck, Zachary Q ^a   Sherman, David H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cryptophycins; Macrolactonization; Safety catch linkers; Solid phase synthesis; Thioesterases

Indexed keywords

ESTERS; REACTION KINETICS; SUBSTRATES; SYNTHESIS (CHEMICAL);

CRYPTOPHYCIN THIOESTERASE (CRPTE); CRYPTOPHYCINS; MACROLACTONIZATION;

ENZYME ACTIVITY;

DEPSIPEPTIDE; LACTONE; THIOL ESTER HYDROLASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; SYNTHESIS;

CYCLIZATION; DEPSIPEPTIDES; LACTONES; MOLECULAR STRUCTURE; THIOLESTER HYDROLASES;

EID: 37349033244     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200703665     Document Type: Article

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