Leishmania chagasi: Homogenous metacyclic promastigotes isolated by buoyant density are highly virulent in a mouse model

Experimental Parasitology

Volumn 118, Issue 1, 2008, Pages 129-133

  Yao, Chaoqun ^a,b   Chen, Yani ^a   Sudan, Bayan ^a   Donelson, John E ^c   Wilson, Mary E ^a,b,c  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Bauhinia purpurea lectin; BPL; Buoyant density; Leishmania; lipophosphoglycan; LPG; mAb; major surface protease; Metacyclic promastigote; monoclonal antibody; MSP; peanut agglutinin; PNA; Virulence

Indexed keywords

ISOENZYME; MAJOR SURFACE PROTEASE; PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; LEISHMANIA CHAGASI; LYSIS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PARASITE ISOLATION; PARASITE VIRULENCE; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN EXPRESSION; PROTEIN FOLDING;

ANIMALS; CRICETINAE; DISEASE MODELS, ANIMAL; FEMALE; GLYCOSPHINGOLIPIDS; ISOENZYMES; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LIVER; MICE; MICE, INBRED BALB C; PEPTIDE HYDROLASES; SPLEEN; VIRULENCE;

ARACHIS HYPOGAEA; BAUHINIA PURPUREA; LEISHMANIA DONOVANI CHAGASI;

EID: 37349017579     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2007.06.012     Document Type: Article

References (29)

1. Ahmed S., Colmenares M., Soong L., Goldsmith-Pestana K., Munstermann L., Molina R., and McMahon-Pratt D. Intradermal infection model for pathogenesis and vaccine studies of murine visceral leishmaniasis. Infection & Immunity 71 (2003) 401-410
2. Akilov O.E., Kasuboski R.E., Carter C.R., and McDowell M.A. The role of mannose receptor during experimental leishmaniasis. Journal of Leukocyte Biology 81 (2007) 1188-1196
3. Almeida M.C., Cuba C.A., de Sa C.M., Pharoah M.M., Howard K.M., and Miles M.A. Metacyclogenesis of Leishmania (Viannia) braziliensis in vitro: evidence that lentil lectin is a marker of complement resistance and enhanced infectivity. Transactions of the Royal Society of Tropical Medicine and Hygiene 87 (1993) 325-329
4. Bandyopadhyay P., Ghosh D.K., De A., Ghosh K.N., Chaudhuri P.P., Das P., and Bhattacharya A. Metacyclogenesis of Leishmania spp.: species-specific in vitro transformation, complement resistance, and cell surface carbohydrate and protein profiles. Journal of Parasitology 77 (1991) 411-416
5. Berens R.L., Brun R., and Krassner S.M. A simple monophasic medium for axenic culture of hemoflagellates. Journal of Parasitology 62 (1976) 360-365
6. Bradley D.J., and Kirkley J. Regulation of Leishmania populations within the host. I: the variable course of Leishmania donovani infections in mice. Clinical and Experimental Immunology 30 (1977) 119-129
7. Brittingham A., Miller M.A., Donelson J.E., and Wilson M.E. Regulation of GP63 mRNA stability in promastigotes of virulent and attenuated Leishmania chagasi. Molecular & Biochemical Parasitology 112 (2001) 51-59
8. Courret N., Prina E., Mougneau E., Saraiva E.M., Sacks D.L., Glaichenhaus N., and Antoine J.C. Presentation of the Leishmania antigen LACK by infected macrophages is dependent upon the virulence of the phagocytosed parasites. European Journal of Immunology 29 (1999) 762-773
9. Da Silva R., and Sacks D.L. Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation. Infection & Immunity 55 (1987) 2802-2806
10. Howard M.K., Sayers G., and Miles M.A. Leishmania donovani metacyclic promastigotes: transformation in vitro, lectin agglutination, complement resistance, and infectivity. Experimental Parasitology 64 (1987) 147-156
11. Lira R., Mendez S., Carrera L., Jaffe C., Neva F., and Sacks D. Leishmania tropica: the identification and purification of metacyclic promastigotes and use in establishing mouse and hamster models of cutaneous and visceral disease. Experimental Parasitology 89 (1998) 331-342
12. Liu X., and Chang K.P. Identification by extrachromosomal amplification and overexpression of a zeta-crystallin/NADPH-oxidoreductase homologue constitutively expressed in Leishmania spp. Molecular & Biochemical Parasitology 66 (1994) 201-210
13. McConville M.J., Turco S.J., Ferguson M.A., and Sacks D.L. Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage. EMBO Journal 11 (1992) 3593-3600
14. Miller M.A., McGowan S.E., Gantt K.R., Champion M., Novick S.L., Andersen K.A., Bacchi C.J., Yarlett N., Britigan B.E., and Wilson M.E. Inducible resistance to oxidant stress in the protozoan Leishmania chagasi. Journal of Biological Chemistry 275 (2000) 33883-33889
15. Nieves E., and Pimenta P.F. Development of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis in the sand fly Lutzomyia migonei (Diptera: Psychodidae). Journal of Medical Entomology 37 (2000) 134-140
16. Pinto-da-Silva L.H., Camurate M., Costa K.A., Oliveira S.M., da Cunha-e-Silva N.L., and Saraiva E.M. Leishmania (Viannia) braziliensis metacyclic promastigotes purified using Bauhinia purpurea lectin are complement resistant and highly infective for macrophages in vitro and hamsters in vivo. International Journal for Parasitology 32 (2002) 1371-1377
17. Roberts S.C., Wilson M.E., and Donelson J.E. Developmentally regulated expression of a novel 59-kDa product of the major surface protease (Msp or gp63) gene family of Leishmania chagasi. Journal of Biological Chemistry 270 (1995) 8884-8892
18. Sacks D.L. Metacyclogenesis in Leishmania promastigotes. Experimental Parasitology 69 (1989) 100-103
19. Sacks D.L., and da Silva R.P. The generation of infective stage Leishmania major promastigotes is associated with the cell-surface expression and release of a developmentally regulated glycolipid. Journal of Immunology 139 (1987) 3099-3106
20. Sacks D.L., Pimenta P.F., McConville M.J., Schneider P., and Turco S.J. Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan. Journal of Experimental Medicine 181 (1995) 685-697
21. Saraiva E.M., Pinto-da-Silva L.H., Wanderley J.L., Bonomo A.C., Barcinski M.A., and Moreira M.E. Flow cytometric assessment of Leishmania spp. metacyclic differentiation: validation by morphological features and specific markers. Experimental Parasitology 110 (2005) 39-47
22. Spath G.F., and Beverley S.M. A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation. Experimental Parasitology 99 (2001) 97-103
23. Stauber L.A. Host resistance to the Khartoum strain of Leishmania donovani. Rice Institute Pamphlets 45 (1958) 80-90
24. Svensjo E., Batista P.R., Brodskyn C.I., Silva R., Lima A.P., Schmitz V., Saraiva E., Pesquero J.B., Mori M.A., Muller-Esterl W., and Scharfstein J. Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex. Microbes and Infection 8 (2006) 206-220
25. Wilson M.E., Hardin K.K., and Donelson J.E. Expression of the major surface glycoprotein of Leishmania donovani chagasi in virulent and attenuated promastigotes. Journal of Immunology 143 (1989) 678-684
26. Wilson M.E., Sandor M., Blum A.M., Young B.M., Metwali A., Elliott D., Lynch R.G., and Weinstock J.V. Local suppression of IFN-gamma in hepatic granulomas correlates with tissue-specific replication of Leishmania chagasi. Journal of Immunology 156 (1996) 2231-2239
27. Yao C., Leidal K.G., Brittingham A., Tarr D.E., Donelson J.E., and Wilson M.E. Biosynthesis of the major surface protease GP63 of Leishmania chagasi. Molecular & Biochemical Parasitology 121 (2002) 119-128
28. Yao C., Luo J., Hsiao C., Donelson J.E., and Wilson M.E. Internal and surface subpopulations of the major surface protease (MSP) of Leishmania chagasi. Molecular & Biochemical Parasitology 139 (2005) 173-183
29. Yao C., Luo J., Storlie P., Donelson J.E., and Wilson M.E. Multiple products of the Leishmania chagasi major surface protease (MSP or GP63) gene family. Molecular & Biochemical Parasitology 135 (2004) 171-183