Feasibility studies of 4′-[methyl-11C]thiothymidine as a tumor proliferation imaging agent in mice

Nuclear Medicine and Biology

Volumn 35, Issue 1, 2008, Pages 67-74

  Toyohara, Jun ^a   Okada, Maki ^a   Toramatsu, Chie ^a   Suzuki, Kazutoshi ^a   Irie, Toshiaki ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

11C; DNA synthesis; PET; Proliferation; S dThd; Tumor

Indexed keywords

4' [METHYL]THIOTHYMIDINE CARBON 11; CARBON 11; DNA; METHYL IODIDE; PALLADIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CROSS COUPLING REACTION; DNA METABOLISM; DNA SYNTHESIS; FEASIBILITY STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; TISSUE DISTRIBUTION;

ANIMALS; CARBON RADIOISOTOPES; CELL PROLIFERATION; DNA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED ICR; NEOPLASMS, EXPERIMENTAL; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; THIONUCLEOSIDES; THYMIDINE; TISSUE DISTRIBUTION;

EID: 37349013378     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2007.10.001     Document Type: Article

References (31)

1. 18F]-FMAU). J Label Compd Radiopharm 45 (2002) 583-590
2. 11C]-FMAU): a potential nucleoside analog for the in vivo study of cellular proliferation with PET. Nucl Med Biol 22 (1995) 783-789
3. 18F]labelled FAU, FMAU, FBAU, FIAU. Nucl Med Biol 30 (2003) 215-224
4. 18F]FMAU and positron emission tomography in patients with cancer. Eur J Nucl Med Mol Imaging 32 (2005) 15-22
5. Shields A.F., Grierson J.R., Dohmen B.M., Machulla H.-J., Stayanoff J.C., Lawhorn-crews J.M., et al. Imaging proliferation in vivo with [F-18]FLT and positron emission tomography. Nat Med 4 (1998) 1334-1336
6. 18F]FLT for imaging of cellular proliferation in vivo. Nucl Med Biol 27 (2000) 143-156
7. Grierson J.R., Schwartz J.L., Muzi M., Jordan R., and Krohn K.A. Metabolism of 3′-deoxy-3′-[F-18]fluorothymidine in proliferating A549 cells: validations for positron emission tomography. Nucl Med Biol 31 (2004) 829-837
8. Toyohara J., and Fujibayashi Y. Trends in nucleoside tracers for PET imaging of cell proliferation. Nucl Med Biol 30 (2003) 681-685
9. 18F-FLT and thymidine analogs: promise and pitfalls. J Nucl Med 44 (2003) 1432-1434
10. Krohn K.A., Mankoff D.A., Muzi M., Link J.M., and Spence A.M. True tracers: comparing FDG with glucose and FLT with thymidine. Nucl Med Biol 32 (2005) 663-671
11. Johansson N.G., and Eriksson S. Structure-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases. Acta Biochim Pol 43 (1996) 143-160
12. 3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines. Nucl Med Biol 29 (2002) 281-287
13. Kawai H., Toyohara J., Kado H., Nakagawa T., Takamatsu S., Furukawa T., et al. Acquisition of resistance to antitumor alkylating agent ACNU: a possible target of positron emission tomography monitoring. Nucl Med Biol 33 (2006) 29-35
14. 1H NMR spectroscopy and X-ray crystallography. J Am Chem Soc 114 (1992) 9936-9943
15. Parker W.B., Shaddix S.C., Rose L.M., Tiwari K.N., Montgomery J.A., Secrist III J.A., et al. Metabolism and metabolic actions of 4′-thiothymidine in L1210 cells. Biochem Pharmacol 50 (1995) 687-695
16. 14C]thiothymidine for in vivo DNA synthesis imaging. J Nucl Med 47 (2006) 1717-1722
17. 11C]thiothymidine for imaging DNA synthesis in vivo. J Labelled Compd Radiopharm 50 (2007) S57
18. 125I-4′-thio-2′-deoxyuridine as a potential iodinated proliferation marker. J Nucl Med 43 (2002) 1218-1226
19. 11C]RO 15-1788 for PET studies of benzodiazepine receptors. Int J Appl Radiat Isot 36 (1985) 971-976
20. Kassis AI, Foulon CF, Adelstein SJ. Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides from stannyl precursors. United States Patent 5720935, 1998.
21. 11C]methyl iodide. J Label Compd Radiopharm 46 (2003) 263-272
22. Quackenbush R.C., and Shields A.F. Local re-utilization of thymidine in normal mouse tissues as measured with iododeoxyuridine. Cell Tissue Kinet 21 (1988) 381-387
23. Hudson H.M., and Larkin R.S. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging 13 (1994) 601-609
24. 11C]methyl iodide. In: Schubiger P.A., Lehman L., and Fribe M. (Eds). PET chemistry. The driving force in molecular imaging (2007), Springer-Verlag, Berlin 183-213
25. 3-labeled PET tracers. Chem Eur J 3 (1997) 2039-2042
26. Muzi M., Vesselle H., Grierson J.R., Mankoff D.A., Schmidt R.A., Peterson L.M., et al. Kinetic modeling of 3′-deoxy-3′-fluorothymidine in somatic tumors: validation in patients with lung cancer. J Nucl Med 46 (2005) 272-284
27. Patlak C.S., Blasberg R.G., and Fenstermacher J.D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3 (1983) 1-7
28. 18F-FDG for differentiating tumor from inflammation in a rodent model. J Nucl Med 45 (2004) 695-700
29. Bading J.R., Shahinian A.H., Vail A., Bathija P., Koszalka G.W., Koda R.T., et al. Pharmacokinetics of the thymidine analog 2′-fluoro-5-methyl-1-β-d-arabinofuranosyluracil (FMAU) in tumor-bearing rats. Nucl Med Biol 31 (2004) 407-418
30. 18F-FMAU and PET. J Nucl Med 46 (2005) 292-296
31. 18F-fluoro-1-β-d-arabinofuranosyl)-5-bromouracil: PET imaging studies in dogs. J Nucl Med 46 (2005) 1916-1922