The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain

Russian Journal of Genetics

Volumn 43, Issue 12, 2007, Pages 1408-1412

  Kulikov, A V ^a   Osipova, D V ^a   Popova, N K ^a  

^a INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 37349007261     PISSN: 10227954     EISSN: 16083369     Source Type: Journal    
DOI: 10.1134/S1022795407120101     Document Type: Article

References (30)

1. Popova, N.K., Naumenko, E.V., and Kolpakov, V.G., Serotonin i povedenie (Serotonin and Behavior), Novosibirsk: Nauka, 1978.
2. Lucki, I., The Spectrum of Behaviors Influenced by Serotonin, Biol. Psychiatry, 1998, vol. 44, no. 3, pp. 151-162.
3. Lesch, K.P., Gene-Environment Interaction and the Genetics of Depression, J. Psychiatry Neurosci., 2004, vol. 29, no. 3, pp. 174-184.
4. Popova, N.K, Brain Serotonin in Genetically Defined Defensive Behavior, Complex Brain Functions: Conceptual Advances in Russian Neuroscience, Millar, R., Ivanitsky, A.M., and Balaban, P.M., Eds., Harwood Academic, 1999, pp. 317-329.
5. Popova, N.K., From Genes to Aggressive Behavior: The Role of Serotonergic System, BioEssays, 2006, vol. 28, no. 5, pp. 495-503.
6. Maes, M. and Meltzer, H.Y., The Serotonin Hypothesis of Major Depression, Psychopharmacology: The Fourth Generation of Progress, Bloom, E.E. and Kupfer, N.N., Eds., New York: Raven, 1995, pp. 933-944.
7. Veenstra-Vander Weele J., Anderson G.M., and Cook E.H., Pharmacogenetics and the Serotonin System: Initial Studies and Future Directions, Eur. J. Pharmacol., 2000, vol. 410, nos. 2-3, pp. 165-181.
8. Gingrich, J.A. and Hen, R., Dissecting the Role of the Serotonin System in Neuropsychiatric Disorders Using Knockout Mice, Psychopharmacology, 2001, vol. 155, no. 1, pp. 1-10.
9. Albert, V.R., Allen, J.M., and Joh, T.H., A Single Gene Codes for Aromatic, L-Amino Acid Decarboxylase in Both Neuronal and Non-Neuronal Tissues, J. Biol. Chem., 1987, vol. 262, pp. 9404-9411.
10. Fitzpatrick, P.F., Tetrahydropterin-Dependent Amino Acid Hydroxylases, Annu. Rev. Biochem., 1999, vol. 68, pp. 355-381.
11. Koe, B.K. and Weissman, A., p-Chlorophenylalanine: A Specific Depletor of Brain Serotonin, J. Pharmacol. Exp. Ther., 1966, vol. 154, no. 3, pp. 499-516.
12. Grenett, H.E., Ledley, F.D., Reed, L.L., and Woo, S.L.C., Full-Length cDNA for Rabbit Tryptophan Hydroxylase: Functional Domains and Evolution of Aromatic Amino Acid Hydroxylases, Proc. Natl. Acad. Sci. USA, 1987, vol. 84, no. 16, pp. 5530-5534.
13. Darmon, M.C., Guibert, B., Leviel, V., et al., Sequence of Two mRNAs Encoding Active Rat Tryptophan Hydroxylase, J. Neurochem., 1988, vol. 51, no. 1, pp. 312-316.
14. Boularand, S., Darmon, M.C., and Mallet, J., The Human Tryptophan Hydroxylase Gene: An Unusual Splicing Complexity in the 5'-Untranslated Region, J. Biol. Chem., 1995, vol. 270, no. 8, pp. 3748-3756.
15. Ledley, F.D., Grenett, H.F., Barton, D.P., et al., Assignment of Human Tryptophan Hydroxylase Locus to Chromosome 11: Gene Duplication and Translocation in Evolution of Aromatic Amino Acid Hydroxylases, Somatic Cell Mol. Genet., 1987, vol. 13, no. 5, pp. 575-580.
16. Nielsen, D.A., Dean, M., and Goldman, D., Genetic Mapping of the Human Tryptophan Hydroxylase Gene on Chromosome 11, Using an Intronic Conformational Polymorphism, Am. J. Hum. Genet., 1992, vol. 51, no. 6, pp. 1366-1371.
17. Stoll, J., Kozak, C., and Goldman, D., Characterization and Chromosomal Mapping of a cDNA Encoding Tryptophan Hydroxylase from a Mouse Mastocytoma Cell Line, Genomics, 1990, vol. 7, no. 1, pp. 88-96.
18. Walther, D.J., Peter, J.-U., Bashammakh, S., et al., Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform, Science, 2003, vol. 299, no. 5603, p. 76.
19. Harvey, M., Shink, E., Tremblay, M., et al., Support for the Involvement of TPH2 Gene in Affective Disorders, Mol. Psychiatry, 2004, vol. 9, no. 11, pp. 980-981.
20. Walther, D. and Bader, M., A Unique Central Tryptophan Hydroxylase Isoform, Biochem. Pharmacol., 2003, vol. 66, no. 9, pp. 1673-1680.
21. Kulikov, A.V. and Popova, N.K., Tryptophan Hydroxylase Activity in the Mouse Brain, Neirokhimiya, 1983, vol. 2, pp. 421-425.
22. Kulikov, A.V. and Popova, N.K., Genetic Control of Tryptophan Hydroxylase Activity in the Mouse Brain, Genetika (Moscow), 1983, vol. 19, no. 5, pp. 784-788.
23. Ginzburg, E.Kh. and Kulikov, A.V., Verification of Monogenic Hypotheses in a Hybridological Analysis of Quantitative Traits, Genetika (Moscow), 1983, vol. 19, no. 4, pp. 571-576.
24. Zhang, X., Beaulieu, J.M., Sotnikova, T.D., et al., Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis, Science, 2004, vol. 305, no. 5681, p. 217.
25. Kulikov, A.V., Osipova, D.V., Naumenko, V.S., and Popova, N.K., The C1473G Polymorphism in the Tryptophan Hydroxylase-2 Gene and Intermale Aggression in Mice, Dokl. Akad. Nauk, 2005, vol. 402, pp. 571-573.
26. Kulikov, A.V., Voronova, I.P., and Zhanaeva, E.Yu., A Sensitive Assay of Tryptophane Hydroxylase Activity in Brain, Vopr. Med. Khim., 1988, no. 2, pp. 120-123.
27. Kulikov, A.V. and Voronova, I.P., Role of Reversible Phosphorylation in Genetically Determined Polymorphism for Cerebral Tryptophan Hydroxylase, Byull. Eksp. Biol. Med., 1995, vol. 119, no. 1, pp. 67-68.
28. Sakowski, S.A., Geddes, T.J., and Kuhn, D.M., Mouse Tryptophan Hydroxylase Isoform 2 and the Role of Proline 447 in Enzyme Function, J. Neurochem., 2006, vol. 96, no. 3, pp. 758-765.
29. Zhang, X., Beaulieu, J.M., Gainetdinov, R.R., and Caron, M.G., Functional Polymorphisms of the Brain Serotonin Synthesizing Enzyme Tryptophan Hydroxylase-2, Cell Mol. Life Sci., 2006, vol. 63, no. 1, pp. 6-11.
30. Zhang, X., Gainetdinov, R.R., Beaulieu, J.M., et al., Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression, Neuron, 2005, vol. 45, no. 1, pp. 11-16.