Radical scavenging activity and inhibition of macrophage NO production by fukinolic acid, a main phenolic constituent in Japanese butterbur (Petasites japonicus)

Food Science and Technology Research

Volumn 13, Issue 4, 2007, Pages 366-371

  Watanabe, Satoru ^a   Hashimoto, Ken ^b   Tazaki, Hiroyuki ^c   Iwamoto, Yuzuri ^d   Shinohara, Naoko ^a   Satoh, Kazue ^e   Sakagami, Hiroshi ^b  

^a Katsushika   (Japan)

^b MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^c NIPPON VETERINARY AND LIFE SCIENCE UNIVERSITY   (Japan)

^d RESEARCH INSTITUTE OF ENVIRONMENT   (Japan)

^e SHOWA UNIVERSITY   (Japan)

Author keywords

ESR; Fukinolic acid; Inducible NO synthase; NO; Scavenging activity

Indexed keywords

PETASITES; PETASITES JAPONICUS;

EID: 37249081649     PISSN: 13446606     EISSN: None     Source Type: Journal    
DOI: 10.3136/fstr.13.366     Document Type: Article

References (16)

1. Burdette, J.E., Chen, S.N., Lu, Z.Z., Xu, H., White, B.E., Fabricant, D. S., Liu, J., Fong, H.S., Farnsworth, N.R., Constantinou, A.I., Van Breemen, R.V., Pezutto, J.M. and Bolton, J.L. (2002). Black cohosh (Cimicifuga racemosa L.) protects against menadioneinduced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. J. Agric. Food Chem., 50, 7022-7028.
2. Endo, M. and Kuroiwa, Y. (2005). Neurotransmitter related to headache. J. Clin. Exp. Exp. Med. (Igaku no Ayumi) 215, 1071-1074 (in Japanese).
3. Hasa, Y. and Tazaki, H. (2004). Biosynthesis of fukinolic acid, isolated from Petasites japonicus. Biosci. Biotechnol. Biochem., 68, 2212-2214.
4. Iwamoto Y., Nakasone W. and Ezura H. (2007). Efficient selection of a high-yield line by using somaclonal variation in Japanese butterbur (Petasites japonicus). Plant Biotechnol. 24, 289-293.
5. Islam, MD. S., Yoshimoto, M., Yahara, S., Okuno, S., Ishiguro, K. and Yamakawa, O. (2002). Identification and characterization of foliar polyphenols composition in sweet potato (Ipomoea batatas L.) genotypes. J. Agric. Food. Chem., 50, 3718-3722.
6. Kruse, S.O., Lohning, A., Pauli, F.G., Winterhoff, H. and Nahrstedt, A. (1999), Fukilic and piscidic acid esters from the rhizome of Cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid. Planta Med., 65, 763-764.
7. Kusano, A., Seyama, Y., Nagai, M., Shibano, M. and Kusano, G. (2001). Effects of fukinolic acid and cimicifugic acids from Cimicifuga species on collagenolytic activity. Biol. Pharm. Bull., 24, 1198-1201.
8. Kusano, G., Takahira, M., Shibano, M., Kusano, A., Okamoto, Y., Tsujibo, H., Numata, A. and Inamori Y., (1998). Studies on inhibitory activities of fukilic acid esters on germination, aamylase and carboxypeptidase A. Biol. Pharm. Bull., 21, 997-999.
9. Loser, B., Kruse, S.O., Melzig, M.F. and Nahrstedt, A. (2000). Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa. Planta Med., 66, 751-753.
10. Murad, F. (1998). Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone? Recent Prog Hormon Res. 53, 43-60.
11. Noda, Y., Mori, A. and Packer, L. (1997). Gliclazide scavenges hydroxyl, superoxide and nitric oxide radicals. An ESR study. Res. Commun. Mol. Pathol. Pharmacol., 96, 115-124.
12. Noguchi, M., Nagai, M., Koeda, M., Nakayama, S., Sakurai, N., Takahira, M. and Kusano, G. (1998). Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in Cimicifuga rhizome. Biol. Pharm. Bull., 21, 1163-1168.
13. Sakamura, S., Yoshihara, A. and Toyoda, K. (1969). Fukiic acid isolated from the hydrolysate of a polyphenol in Petasites japonicus. Agriec. Biol. Chem., 33, 1795-1797.
14. Takahira, M., Kusano, A., Shibano, M., Kusano, G. and Miyase, T. (1998). Piscidic acid and fukiic acid esters from Cimicifuga Simplex. Phytochemistry, 49, 2115-2119.
15. Takahira, M., Kusano, A., Shibano, M., Kusano, G., Sakurai, N., Nagai, M. and Miyase T. (1998), Three new fukiic acid esters, cimicifugic acids A, B and C, from Cimicifuga simplex Wormsk. Chem. Pharm. Bull., 46, 362-365.
16. Terasaka, H., Machino, M., Saito, M., Fujisawa, S., Satoh, K., Jiang, Y. and Sakagami, H. (2002). Re-evaluation of antitumor activity of Cepharanthin. Anticancer Res., 22, 165-170.