The lymphatic infiltration identified by D2-40 monoclonal antibody predicts lymph node metastasis in submucosal invasive colorectal cancer

Pathobiology

Volumn 74, Issue 6, 2007, Pages 328-335

  Kawaura, Ken ^a,c   Fujii, Satoshi ^a   Murata, Yukinori ^b   Hasebe, Takahiro ^a   Ishii, Genichiro ^a   Itoh, Tohru ^c   Sano, Yasushi ^b   Saito, Norio ^b   Ochiai, Atsushi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Colorectal cancer, submucosal invasive; D2 40; Endoscopic resection; Lymph node metastasis; Lymphatic infiltration; Risk factor

Indexed keywords

DYE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY D240; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER INFILTRATION; CANCER INVASION; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; STAINING; SUBMUCOSA; VASCULAR ENDOTHELIUM; VEIN;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MIDDLE AGED; RISK FACTORS;

EID: 37249045137     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000110026     Document Type: Article

References (35)

1. Kitamura K, Taniguchi H, Yamaguchi T, Sawai K, Takahashi T: Clinical outcome of surgical treatment for invasive early colorectal cancer in Japan. Hepatogastroenterology 1997;44:108-115.
2. Rembacken BJ, Fujii T, Cairns A, et al: Flat and depressed colonic neoplasms: a prospective study of 1,000 colonoscopies in the UK. Lancet 2000;355:1211-1214.
3. Kaihara T, Sano Y, Okuno T, et al: Endoscopic therapy for colorectal cancer. Nippon Rinsho 2003;61(suppl 7):533-539.
4. Chantereau MJ, Faivre J, Boutron MC, et al: Epidemiology, management, and prognosis of malignant large bowel polyps within a defined population. Gut 1992;33:259-263.
5. Mainprize KS, Mortensen NJ, Warren BF: Early colorectal cancer: recognition, classification and treatment. Br J Surg 1998;85:469-476.
6. Akasu T, Kondo H, Moriya Y, et al: Endorectal ultrasonography and treatment of early stage rectal cancer. World J Surg 2000;24:1061-1068.
7. Haggitt RC, Glotzbach RE, Soffer EE, Wruble LD: Prognostic factors in colorectal carcinomas arising in adenomas: implications for lesions removed by endoscopic polypectomy. Gastroenterology 1985;89:328-336.
8. Coverlizza S, Risio M, Ferrari A, Fenoglio-Preiser CM, Rossini FP: Colorectal adenomas containing invasive carcinoma. Pathologic assessment of lymph node metastatic potential. Cancer 1989;64:1937-1947.
9. Tanaka S, Yokota T, Saito D, Okamoto S, Oguro Y, Yoshida S: Clinicopathologic features of early rectal carcinoma and indications for endoscopic treatment. Dis Colon Rectum 1995;38:959-963.
10. Cooper HS, Deppisch LM, Gourley WK, et al: Endoscopically removed malignant colorectal polyps: clinicopathologic correlations. Gastroenterology 1995;108:1657-1665.
11. Volk EE, Goldblum JR, Petras RE, Carey WD, Fazio VW: Management and outcome of patients with invasive carcinoma arising in colorectal polyps. Gastroenterology 1995;109:1801-1807.
12. Netzer P, Forster C, Biral R, et al: Risk factor assessment of endoscopically removed malignant colorectal polyps. Gut 1998;43:669-674.
13. Egashira Y, Yoshida T, Hirata I, et al: Analysis of pathological risk factors for lymph node metastasis of submucosal invasive colon cancer. Mod Pathol 2004;17:503-511.
14. Ueno H, Mochizuki H, Hashiguchi Y, et al: Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology 2004;127:385-394.
15. Kitajima K, Fujimori T, Fujii S, et al: Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study. J Gastroenterol 2004;39:534-543.
16. Nivatvongs S, Rojanasakul A, Reiman HM, et al: The risk of lymph node metastasis in colorectal polyps with invasive adenocarcinoma. Dis Colon Rectum 1991;34:323-328.
17. Kyzer S, Begin LR, Gordon PH, Mitmaker B: The care of patients with colorectal polyps that contain invasive adenocarcinoma. Endoscopic polypectomy or colectomy? Cancer 1992;70:2044-2050.
18. Kudo S: Endoscopic mucosal resection of flat and depressed types of early colorectal cancer. Endoscopy 1993;25:455-461.
19. Wilcox GM, Anderson PB, Colacchio TA: Early invasive carcinoma in colonic polyps. A review of the literature with emphasis on the assessment of the risk of metastasis. Cancer 1986;57:160-171.
20. Muller S, Chesner IM, Egan MJ, et al: Significance of venous and lymphatic invasion in malignant polyps of the colon and rectum. Gut 1989;30:1385-1391.
21. Vass DG, Ainsworth R, Anderson JH, Murray D, Foulis AK: The value of an elastic tissue stain in detecting venous invasion in colorectal cancer. J Clin Pathol 2004;57:769-772.
22. Franchi A, Gallo O, Massi D, Baroni G, Santucci M: Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations. Cancer 2004;101:973-978.
23. Kahn HJ, Bailey D, Marks A: Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol 2002;15:434-440.
24. Kahn HJ, Marks A: A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest 2002;82:1255-1257.
25. Dumoff KL, Chu C, Xu X, Pasha T, Zhang PJ, Acs G: Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol 2005;18:97-104.
26. Fogt F, Pascha TL, Zhang PJ, Gausas RE, Rahemtulla A, Zimmerman RL: Proliferation of D2-40-expressing intestinal lymphatic vessels in the lamina propria in inflammatory bowel disease. Int J Mol Med 2004;13:211-214.
27. Fogt F, Zimmerman RL, Ross HM, Daly T, Gausas RE: Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep 2004;11:47-50.
28. Fukunaga M: Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology 2005;46:396-402.
29. Choi WW, Lewis MM, Lawson D, et al: Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression. Mod Pathol 2005;18:143-152.
30. Giorgadze TA, Baloch ZW, Pasha T, Zhang PJ, Livolsi VA: Lymphatic and blood vessel density in the follicular patterned lesions of thyroid. Mod Pathol 2005;18:1424-1431.
31. Zeng Y, Opeskin K, Horvath LG, Sutherland RL, Williams ED: Lymphatic vessel density and lymph node metastasis in prostate cancer. Prostate 2005;65:222-230.
32. Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC: Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 2002;40:127-132.
33. Hase K, Shatney C, Johnson D, Trollope M, Vierra M: Prognostic value of tumor 'budding' in patients with colorectal cancer. Dis Colon Rectum 1993;36:627-635.
34. Hase K, Shatney CH, Mochizuki H, et al: Long-term results of curative resection of 'minimally invasive' colorectal cancer. Dis Colon Rectum 1995;38:19-26.
35. Tominaga K, Nakanishi Y, Nimura S, Yoshimura K, Sakai Y, Shimoda T: Predictive histopathologic factors for lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma. Dis Colon Rectum 2005;48:92-100.