A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom

British Journal of Clinical Pharmacology

Volumn 65, Issue 1, 2008, Pages 139-143

  Isbister, Geoffrey K ^a,b,c   O'Leary, Margaret ^b   Miller, Mark ^c,d   Brown, Simon G A ^e   Ramasamy, Sharmaine ^f   James, Rosemary ^b   Schneider, Jennifer S ^c  

^a MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^b NEWCASTLE MATER HOSPITAL   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

^d JOHN HUNTER HOSPITAL   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

Author keywords

Antivenom; Arachnidism; Envenoming; Intramuscular administration; Latrodectus; Widow spider

Indexed keywords

PLACEBO; SPIDER VENOM ANTISERUM;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DETERMINATION; ENZYME IMMUNOASSAY; FEMALE; HUMAN; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPIDER BITE;

ADULT; ANIMALS; ANTIVENINS; ARACHNIDISM; CASE-CONTROL STUDIES; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; SPIDER VENOMS;

EID: 37249043204     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2007.03004.x     Document Type: Article

References (22)

1. Isbister GK, White J. Clinical consequences of spider bites: recent advances in our understanding. Toxicon 2003, 41.
2. Isbister GK, Gray MR. A prospective study of 750 definite spider bites, with expert spider identification. Quart J Med 2002 95 : 723 31.
3. Garb JE, Gonzalez A, Gillespie RG. The black widow spider genus Latrodectus (Araneae: Theridiidae): phylogeny, biogeography, and invasion history. Mol Phylogenet Evol 2004 31 : 1127 42.
4. Isbister GK, Graudins A, White J, Warrell D. Antivenom treatment in arachnidism. J Toxicol Clin Toxicol 2003 41 : 291 300.
5. Clark RF. The safety and efficacy of antivenin Latrodectus mactans. J Toxicol Clin Toxicol 2001 39 : 125 7.
6. Ellis RM, Sprivulis PC, Jelinek GA, Banham ND, Wood SV, Wilkes GJ, Siegmund A, Roberts BL. A double-blind, randomized trial of intravenous versus intramuscular antivenom for red-back spider envenoming. Emerg Med 2005 17 : 152 6.
7. Clark RF, Wethern-Kestner S, Vance MV, Gerkin R. Clinical presentation and treatment of black widow spider envenomation. a review of 163 cases. Ann Emerg Med 1992 21 : 782 7.
8. Isbister GK, Gray MR. Latrodectism: a prospective cohort study of bites by formally identified redback spiders. Med J Aust 2003 179 : 88 91.
9. Lira-d, a-Silva RM, Matos GB, Sampaio RO, Nunes TB. [Retrospective study on Latrodectus stings in Bahia, Brazil]. [in Portuguese]. Rev Soc Bras Med 1995 28 : 205 10.
10. Riviere G, Choumet V, Audebert F, Sabouraud A, Debray M, Scherrmann JM, Bon C. Effect of antivenom on venom pharmacokinetics in experimentally envenomed rabbits: toward an optimization of antivenom therapy. J Pharmacol Exp Ther 1997 281 : 1 8.
11. Krifi MN, Miled K, Abderrazek M, El Ayeb M. Effects of antivenom on Buthus occitanus tunetanus (Bot) scorpion venom pharmacokinetics: towards an optimization of antivenom immunotherapy in a rabbit model. Toxicon 2001 39 : 1317 26.
12. O'Leary MA, Isbister GK, Schneider JJ, Brown SG, Currie BJ. Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: Detecting venom, antivenom and venom-antivenom complexes. Toxicon 2006 48 : 4 11.
13. Theakston RD. The application of immunoassay techniques, including enzyme-linked immunosorbent assay (ELISA), to snake venom research. Toxicon 1983 21 : 341 52.
14. Rash LD, King RG, Hodgson WC. Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata). Toxicon 2000 38 : 1111 27.
15. White J. CSL Antivenom Handbook, 2nd edn. Melbourne, CSL Ltd, 2001.
16. Krifi MN, Savin S, Debray M, Bon C, El Ayeb M, Choumet V. Pharmacokinetic studies of scorpion venom before and after antivenom immunotherapy. Toxicon 2005 45 : 187 98.
17. Krifi MN, Amri F, Kharrat H, El Ayeb M. Evaluation of antivenom therapy in children severely envenomed by Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot) scorpions. Toxicon 1999 37 : 1627 34.
18. Gutierrez JM, Leon G, Lomonte B. Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation. Clin Pharmacokinet 2003 42 : 721 41.
19. Krifi MN, Kharrat H, Zghal K, Abdouli M, Abroug F, Bouchoucha S, Dellagi K, El Ayeb M. Development of an ELISA for the detection of scorpion venoms in sera of humans envenomed by Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot): correlation with clinical severity of envenoming in Tunisia. Toxicon 1998 36 : 887 900.
20. Ghalim N, El-Hafny B, Sebti F, Heidel J, Lazar N, Moustanir R, Benslimane A. Scorpion envenomation and serotherapy in Morocco. Am J Trop Med 2000 62 : 277 83.
21. Chippaux J-P, Goyffon M. Venoms, antivenoms and immunotherapy. Toxicon 1998 36 : 823 46.
22. Crowther JR ELISA, theory and practice. In : Methods in Molecular Biology, Vol. 42. Totowa, NJ : Humana Press, 1995.