Inhibitory effects of the alpha-2 adrenergic agonists clonidine and dexmedetomidine on enhanced airway tone in ovalbumin-sensitized guinea pigs

European Journal of Anaesthesiology

Volumn 25, Issue 1, 2008, Pages 67-71

  Yamakage, M ^a   Iwasaki, S ^a   Satoh, J I ^a   Namiki, A ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway resistance; Clonidine; Dexmedetomidine; Ovalbumin; Receptors adrenergic alpha 2

Indexed keywords

ACETYLCHOLINE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CARBACHOL; CLONIDINE; DEXMEDETOMIDINE; MUSCARINIC AGENT; OVALBUMIN;

AEROSOL; AIRWAY; ANIMAL EXPERIMENT; ARTICLE; CONTINUOUS INFUSION; CONTROL GROUP; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; GUINEA PIG; LUNG RESISTANCE; MALE; MOUSE; MUSCLE CONTRACTION; MUSCLE RELAXATION; NONHUMAN; SENSITIZATION; SMOOTH MUSCLE TONE; TRACHEA;

ACETYLCHOLINE; ADRENERGIC ALPHA-AGONISTS; AIRWAY OBSTRUCTION; ANIMALS; BRONCHIAL HYPERREACTIVITY; CARBACHOL; CLONIDINE; DEXMEDETOMIDINE; GUINEA PIGS; HYPNOTICS AND SEDATIVES; LUNG; MALE; MUSCLE, SMOOTH; OVALBUMIN; SPECIFIC PATHOGEN-FREE ORGANISMS; TRACHEA;

EID: 37249038190     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S0265021507002591     Document Type: Article

References (24)

1. Wright PM, Carabine UA, McClune S et al. Preanaesthetic medication with clonidine. Br J Anaesth 1990; 65: 628-632.
2. Engelman E, Lipszyc M, Gilabrt E et al. Effects of clonidine on anesthetic drug requirements and hemodynamic response during aortic surgery. Anesthesiology 1989; 71: 178-187.
3. Douglas BC, Drew BC, Grald AM. Dexmedetomidine. Curr Opin Crit Care 2001; 7: 221-226.
4. Venn RM, Newman PJ, Grounds RM. A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive Care Med 2003; 29: 201-207.
5. Munoz NM, Leff AR. Evidence for two sybtypes of alpha adrenergic receptors in canine airway smooth muscle. J Pharmacol Exp Ther 1981; 217: 530-535.
6. Advenier C, Floch A, Mallard B. Bronchopulmonary effects of clonidine on the bronchomotor responses of the guinea-pig. Eur J Pharmacol 1983; 89: 85-94.
7. Takayanagi I, Kawano K, Koike K. Alpha 2-adrenoceptor mechanisms in guinea-pig trachea. Eur J Pharmacol 1990; 182: 577-580.
8. Arimitsu M, Mitsui-Saito M, Sato K et al. Mechanism of relaxant of clonidine in isolated bovine tracheal smooth muscle. J Pharmacol Exp Ther 1998; 286: 681-687.
9. Yu M, Wang Z, Robinson N. Prejunctional alpha 2-adrenoceptors inhibit acetylcholine release from cholinergic nerves in equine airways. Am J Physiol 1993; 265: L565-L570.
10. Manning MM, Broadstone RV. Effects of alpha 2-adrenergic receptor agonist and antagonist drugs on cholinergic contraction in bovine tracheal smooth muscle in vitro. Am J Vet Res 1995; 56: 930-935.
11. Groeben H, Mitzner W, Brown RH. Effects of the alpha 2-adrenoceptor agonist dexmedetomidine on bronchoconstriction in dogs. Anesthesiology 2004; 100: 359-363.
12. Boskabady MH, Adel-Kardan S. Increased muscarinic receptor blockade by atropine in tracheal chains of ovalbumin-sensitized guinea pigs. Pharmacology 1999; 58: 300-308.
13. Toward TJ, Broadley KJ. Early and late bronchoconstrictions, airway hyperreactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: Effects of dexamethasone and rolipram. Clin Exp Allergy 2004; 34: 91-102.
14. 4 receptor antagonist on antigen-induced pulmonary reaction. Eur J Pharmacol 1999; 370: 153-159.
15. Iwasaki S, Yamakage M, Satoh J-I, Namiki A. Different inhibitory effects of sevoflurane on hyperreactive airway smooth muscle contractility in ovalbumin-sensitized and chronic cigarette-smoking guinea pig models. Anesthesiology 2006; 105: 753-763.
16. Talke P, Chen R, Thomas B et al. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg 2000; 90: 834-839.
17. 4-induced constriction of guinea-pig trachea. Acta Anaesthesiol Scand 1995; 39: 1111-1116.
18. Ikegami K, Hata H, Fuchigami J-I et al. Apafant (a PAF receptor antagonist) suppresses the early and late airway responses in guinea pigs: a comparison with antiasthmatic drugs. Eur J Pharmacol 1997; 328: 75-81.
19. Bagcivan I, Cevit O, Yildirim MK et al. Investigation of the relaxant effect of propofol on ovalbumin-induced asthma in guinea pigs. Eur J Anaesthesiol 2007; 24: 796-802.
20. Gal TJ, Suratt PM. Resistance to breathing in healthy subjects following endotracheal intubation under topical anesthesia. Anesth Analg 1980; 59: 270-274.
21. Guler G, Akin A, Tosun Z et al. Single-dose dexmedetomidine attenuates airway and circulatory reflexes during extubation. Acta Anaesthesiol Scand 2005; 49: 1088-1091.
22. O'Connell F, Thomas VE, Fuller RW et al. Effect of clonidine on induced cough and bronchoconstriction in guinea pigs and healthy humans. J Appl Physiol 1994; 76: 1082-1087.
23. Dinh Xuan AT, Lockhart A. Bronchial effects of alpha 2-adrenoceptor agonists and of other antihypertensive agents in asthma. Am J Med 1989; 87: 34S-37S.
24. Shibata O, Saito M, Hashimoto S et al. Clonidine attenuates the carbachol-induced contractile and phosphatidylinositol response of rat trachea. J Pharm Pharmacol 2000; 52: 1523-1528.