Apafant (a PAF receptor antagonist) suppresses the early and late airway responses in guinea pigs: A comparison with antiasthmatic drugs

European Journal of Pharmacology

Volumn 328, Issue 1, 1997, Pages 75-81

  Ikegami, Kozaburo ^a   Hata, Hiroko ^a   Fuchigami, Jun Ichi ^b   Tanaka, Katsuyuki ^b   Kohjimoto, Yoshiro ^b   Uchida, Shuji ^a   Tasaka, Kenji ^a  

^a Kawanishi Pharma Res Inst   (Japan)

^b Lab of Pharmacokin and Pharmacol   (Japan)

Author keywords

Airway response; Apafant (WEB 2086 BS); Early; Late

Indexed keywords

ANTIASTHMATIC AGENT; APAFANT; CROMOGLYCATE DISODIUM; DEXAMETHASONE; MEPYRAMINE MALEATE; METYRAPONE; OZAGREL; SALBUTAMOL; THEOPHYLLINE;

AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GUINEA PIG; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030967549     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)83031-2     Document Type: Article

References (18)

1. Ashton J.M., Clark B., Jones K.M., Moss G.F., Neal M.G., Ritchie J.T. The absorption, metabolism and excretion of disodium cromoglycate in nine animal species. Toxicol. Appl. Pharmacol. 26:1973;319.
2. Assem E.S.K., Mongar J.L. Inhibition of allergic reactions in man and other species by cromoglycate. Int. Arch. Allergy Appl. Immunol. 38:1970;68.
3. Assem E.S.K., Richter A.W. Comparison of in vivo and in vitro inhibition of the anaphylactic mechanism by β-adrenergic stimulants and disodium cromoglycate. Immunology. 21:1971;729.
4. Booij-Noord H., Orie N.G.M., De Vries K. Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone. J. Allergy Clin. Immunol. 48:1971;344.
5. Burge P.S., Fethimiou J., Turner-Warwick M., Nelmes P.T.J. Double-blind trials of inhaled beclomethasone diproprionate and fluocortin butyl ester in allergen-induced immediate and late asthmatic reactions. Clin. Allergy. 12:1982;523.
6. Cartier A., Thomson N.C., Frith P.A., Roberts R., Tech M., Hargreaue F.E. Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber. J. Allergy Clin. Immunol. 70:1982;170.
7. Chignard M., Le Còuedic J.P., Andersson P., Brange C. Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis. Int. Arch. Allergy Appl. Immunol. 81:1986;184.
8. Cockcroft D.W., Murdock K.Y. Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone diproprionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine. J. Allergy Clin. Immunol. 79:1987;734.
9. Cox J.S.G. Disodium cromoglycate (Intal). Adv. Drug Res. 5:1970;115.
10. Evans T.W., Chung K.F., Rogers D.F., Barnes P.J. Effect of platelet activating factor on airway vascular permeability: possible mechanism. J. Appl. Physiol. 63:1987;479.
11. Hozawa S., Haruta Y., Ishioka S., Yamakido M. Effects of a PAF receptor antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma. Am. J. Respir. Crit. Care Med. 152:1995;1198.
12. Kuitert L.M., Angus R.M., Barnes N.C., Barnes P.J., Bone M.F., Chung K.F., Fairfax A.J., Higenbotham T.W., O'Conner B.J., Piotrowska B. Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. Am. J. Respir. Crit. Care Med. 151:1995;1331.
13. Lellouch-Tubiana A., Lefort J., Simon M., Pfister A., Vargaftig B.B. Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration: modulation by prostacyclin, platelet depletion, and selective antagonists. Am. Rev. Respir. Dis. 137:1988;948.
14. Matsumoto Y., Ashida Y., Tsukuda R. Pharmacological modulation of immediate and late airway response and leukocyte infiltration in guinea pig. J. Pharmacol. Exp. Ther. 269:1994;1236.
15. Mielens F.E., Ferguson E.W., Rosenberg F.J. Effects of anti-anaphylactic drugs upon passive antibodies in rats. Int. Arch. Allergy Appl. Immunol. 47:1974;633.
16. Miwa M., Miyake T., Yamanaka T., Sugatani J., Suzuki Y., Sakata S., Araki Y., Morimoto M. Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children. J. Clin. Invest. 82:1988;1983.
17. Pennock B.E., Cox C.P., Rogers R.M., Cain W.A., Wèlls J.H. A noninvasive technique for measurement of changes in specific airway resistance. J. Appl. Physiol., Respir. Environ. Exercise Physiol. 42:1979;399.
18. Pepys J., Hutchcroft B.J. Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am. Rev. Respir. Dis. 112:1975;829.