MIP-2 causes differential activation of RhoA in mouse aortic versus pulmonary artery endothelial cells

Microvascular Research

Volumn 75, Issue 1, 2008, Pages 53-58

  Moldobaeva, Aigul ^a   Baek, Amy ^a   Wagner, Elizabeth M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Chemokines; Endothelium

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CHEMOKINE RECEPTOR CXCR2; MACROPHAGE INFLAMMATORY PROTEIN 2; RAC1 PROTEIN; RHO KINASE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA; ARTICLE; CELL MIGRATION; CELL TYPE; CHEMOTAXIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; STATISTICAL SIGNIFICANCE; STRESS FIBER; VASCULAR ENDOTHELIUM; VIRUS INFECTION;

AMIDES; ANIMALS; AORTA; CHEMOKINE CXCL2; CHEMOTAXIS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; PROTEIN KINASE INHIBITORS; PULMONARY ARTERY; PYRIDINES; RAC GTP-BINDING PROTEINS; RECEPTORS, INTERLEUKIN-8B; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STRESS FIBERS;

EID: 37249025815     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2007.06.007     Document Type: Article

References (16)

1. Aird W.C. Mechanisms of endothelial cell heterogeneity in health and disease. Circ. Res. 98 (2006) 159-162
2. Curnock A.P., Logan M.K., and Ward S.G. Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases. Immunology 105 (2002) 125-136
3. Hoang M.V., Whelan M.C., and Senger D.R. Rho activity critically and selectively regulates endothelial cell organization during angiogenesis. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 1874-1879
4. Koch A.E., Polverini P.J., Kunkel S.L., Harlow L.A., DiPietro L.A., Elner V.M., Elner S.G., and Strieter R.M. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258 (1992) 1798-1801
5. Loovers H.M., Postma M., Keizer-Gunnink I., Huang Y.E., Devreotes P.N., and van Haastert P.J. Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol. Biol. Cell 17 (2006) 1503-1513
6. Mitzner W., Lee W., Georgakopoulos D., and Wagner E. Angiogenesis in the mouse lung. Am. J. Pathol. 157 (2000) 93-101
7. Mitzner W., and Wagner E.M. Vascular remodeling in the circulations of the lung. J. Appl. Physiol. 97 (2004) 1999-2004
8. Moldobaeva A., and Wagner E.M. Difference in proangiogenic potential of systemic and pulmonary endothelium: role of CXCR2. Am. J. Physiol., Lung Cell. Mol. Physiol. (2005)
9. Peters D.G., Ning W., Chu T.J., Li C.J., and Choi A.M. Comparative SAGE analysis of the response to hypoxia in human pulmonary and aortic endothelial cells. Physiol. Genomics (2006)
10. Schraufstatter I.U., Chung J., and Burger M. IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways. Am. J. Physiol., Lung Cell. Mol. Physiol. 280 (2001) L1094-L1103
11. Srisuma S., Biswal S.S., Mitzner W.A., Gallagher S.J., Mai K.H., and Wagner E.M. Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling. Am. J. Respir. Cell Mol. Biol. 29 (2003) 172-179
12. Stevens T. Molecular and cellular determinants of lung endothelial cell heterogeneity. Chest 128 (2005) 558S-564S
13. Strieter R.M., Polverini P.J., Kunkel S.L., Arenberg D.A., Burdick M.D., Kasper J., Dzuiba J., Van Damme J., Walz A., Marriott D., et al. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 270 (1995) 27348-27357
14. Tapon N., and Rho H.A. Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol. 9 (1997) 86-92
15. Uchida S., Watanabe G., Shimada Y., Maeda M., Kawabe A., Mori A., Arii S., Uehata M., Kishimoto T., Oikawa T., and Imamura M. The suppression of small GTPase rho signal transduction pathway inhibits angiogenesis in vitro and in vivo. Biochem. Biophys. Res. Commun. 269 (2000) 633-640
16. Wagner E.M., Petrache I., Schofield B., and Mitzner W. Pulmonary ischemia induces lung remodeling and angiogenesis. J. Appl. Physiol. 100 (2006) 587-593