Evaluation of hawthorn extract on immunomodulatory biomarkers in a pressure overload model of heart failure

Medical Science Monitor

Volumn 13, Issue 12, 2007, Pages

  Bleske, Barry E ^a   Zineh, Issam ^b   Hyun, Seok Hwang ^a   Welder, Gregory J ^b   Ghannam, Michael M J ^a   Boluyt, Marvin O ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Animal; Aortic constriction; Chemokines; Cytokines; Hawthorn; Heart failure

Indexed keywords

CRATAEGUS EXTRACT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; HEART FAILURE; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; IMMUNOMODULATION; MALE; MORTALITY; NONHUMAN; RAT; SURGICAL TECHNIQUE;

ANIMALS; AORTA; BIOLOGICAL MARKERS; CONSTRICTION, PATHOLOGIC; CRATAEGUS; CYTOKINES; DISEASE MODELS, ANIMAL; HEART FAILURE; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 37249018516     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Anker SD, von Haehling S: Inflammatory mediators in chronic heart failure: an overview. Heart, 2004; 90: 464-70
2. Welder GJ, Wessel TR, Arant CB et al: Complementary and alternative medicine use among individuals participating in research: Implications for research and practice. Pharmacotherapy, 2006; 26(12): 1794-801
3. Pittler MH, Schmidt K, Ernst E: Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Am J Med, 2003; 114: 665-74
4. Schwinger RH, Pietsch M, Frank K, Brixius K: Crataegus Special Extract WS 1442 increases force of contraction in human myocardium c-AMP-independently. J Cardiovasc Pharmacol, 2000; 35: 700-7
5. Bleske BE, Hwang HS, Zineh I et al: Evaluation of immunomodulatory biomarkers in a pressure overload model of heart failure. Pharmacotherapy, 2007; 27(4): 504-9
6. Cirrincione GM, Boluyt MO, Hwang HS, Bleske BE: 3-Hydroxy-3-Methyl- Glytaryl Coenzyme A Reductase Inhibition and Extracellular Matrix Gene Expression in the Pressure-Overloaded Rat Heart. J Cardiovasc Pharmacol, 2006; 47: 521-30
7. Kuster GM, Kotlyar E, Rude MK et al: Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload. Circulation, 2005; 111: 420-27
8. Turcani M, Rupp H: Bradykinin (B2) independent effect of captopril on the development of pressure overload cardiac hypertrophy. Molecular and Cellular Biochemistry, 2000; 212: 219-25
9. Liu MY, Xydakis AM, Hoogeveen RC et al: Multiplexed Analysis of Biomarkers Related to Obesity and the Metabolic Syndrome in Human Plasma, Using the Luminex-100 System. Clin Chem, 2005; 51: 1102-9
10. Zineh I, Welder GJ, DeBella AE et al: Atorvastatin effect on circulating and leukocyte-produced CD40 ligand concentrations in people with normal cholesterol levels: a pilot study. Pharmacotherapy, 2006; 26(11): 1572-77
11. Li R, Luo X, Pan Q et al: Doxycycline alters the expression of inflammatory and immune-related cytokines and chemokines in human endometrial cells: implication in irregular uterine bleeding. Hum Reprod, 2006; 21(10): 2555-63. Epub 2006 Aug 4
12. Zineh I, Luo X, Welder GJ, Debella AE et al: Modulatory effects of atorvastatin on endothelial cell-derived chemokines, cytokines, and angiogenic factors. Pharmacotherapy, 2006; 26(3): 333-40
13. Gullestad L, Aukrust P: Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches. Am J Cardiol, 2005; 95(Suppl): 17C-23C
14. Prabhu SD: Cytokine-induced modulation of cardiac function. Circ Res, 2004; 95: 1140-53
15. Mehra VC, Ramgolam VS, Bender JR: Cytokines and cardiovascular disease. J Leukoc Biol, 2005; 78: 805-18
16. Long CS: The role of interleukin-1 in the failing heart. Heart Failure Reviews, 2001; 6: 81-94
17. De Waal Malefyt R, Abrams J, Bennett B et al: Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med, 1991; 174: 1209-20
18. Bogdan C, Vodovotz Y, Nathan C: Macrophage deactivation by interleukin-10. J Exp Med, 1991; 174: 1549-55
19. Moore KW, O'Garra A, De Waal Malefty R et al: Interelukin-10. Annu Rev Immunol, 1993; 11: 165-90
20. Sato Y, Takatsu Y, Katoka K et al: Serial circulating concentrations of C-reactive protein, interleukin (IL)-4, and IL-6 in patients with acute left heart decompensation. Clin Cardiol, 1999; 22: 811-13
21. Blake MJ, Goldman JH, Keeling PJ et al: Abnormal cytokine profiles in patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives. Heart, 1996; 75: 287-90
22. Naito Y, Tsujino T, Fujioka Y et al: Increased circulating interleukin-18 in patients with congestive heart failure. Heart, 2002; 88: 296-97
23. Yamaoka M, Yamaguchi S, Okuyama M, Tomoike H: Anti-inflammatory cytokine profile in human heart failure. Jpn Circ J, 1999; 63: 951-56
24. Mu MM, Chakravortty D, Sugiyama T et al: The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. J Endotoxin Res, 2001; 7: 431-38
25. Wadsworth TL, McDonald TL, Koop DR: Effects of Ginko biloba extract and quercetin on lipopolysaccaride induced signaling pathways involved in the release of tumor necrosis factor-alpha. Biochemical Pharmacology, 2001; 62: 963-74
26. Matsuda-Mamani M, Kauss T, Al-Kharrat A et al: Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators. Biochem Pharmacol, 2006; 72: 1304-10
27. Jayalakshmi R, Niranjali DS: Cardioprotective effect of tincture of Crataegus on isoproterenol-induced myocardial infarction in rats. J Pharm Pharmacol, 2004; 56: 921-26
28. Kim SH, Kang KW, Kye WK, Kim ND: Procyanidins in crataegus extract evoke endothelium-dependent vasorelaxation in rat aorta. Life Sciences, 2000; 67: 121-31