CSP deposition to the alveolar region of the lung: Implications of cigarette design

Risk Analysis

Volumn 27, Issue 6, 2007, Pages 1519-1533

  Gower, Stephanie ^a   Hammond, David ^b  

^a TORONTO PUBLIC HEALTH   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Cigarette design; Cigarette ventilation; Compensation; CSP; Lung deposition

Indexed keywords

CIGARETTE FILTERS; HEALTH CARE; MATHEMATICAL MODELS; ONCOLOGY; PULMONARY DISEASES; SMOKE;

CIGARETTE DESIGN; CIGARETTE VENTILATION; COMPENSATION; LUNG DEPOSITION; PARTICLE DEPOSITION PATTERNS;

HUMAN ENGINEERING;

CIGARETTE SMOKE;

CANCER; COAGULATION; HYGROSCOPICITY; NUMERICAL METHOD; SMOKING;

AIRWAY; ARTICLE; BREATH HOLDING; CIGARETTE SMOKING; COMPENSATION; EXHALATION; FLOW RATE; HUMAN; INHALATION; LUNG ALVEOLUS; LUNG CANCER; LUNG DEPOSIT; LUNG PARENCHYMA; LUNG VENTILATION; MATHEMATICAL MODEL; PARTICLE SIZE; PARTICULATE MATTER; VALIDATION PROCESS;

HUMANS; INHALATION; MODELS, BIOLOGICAL; PARTICLE SIZE; PULMONARY ALVEOLI; RISK; SMOKE; SMOKING; TOBACCO;

NEPTUNIA;

EID: 37249008220     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2007.00986.x     Document Type: Article

References (109)

1. Borgerding, M., & Klus, H. (2005). Analysis of complex mixtures - Cigarette smoke. Experimental and Toxicologic Pathology, 57, 43 73.
2. Surgeon General 1984). Deposition and Toxicity of Tobacco Smoke in the Lung, in The Health Consequences of Smoking: Chronic Obstructive Lung Disease: A Report of the Surgeon General, United States. Rockville, MD: Public Health Service. Office on Smoking and Health. p. 1 25.
3. Hammond, D., Collishaw, N. E., & Callard, C. (2006). Secret science: Tobacco industry research on smoking behaviour and cigarette toxicity. The Lancet, 367, 781 787.
4. Benowitz, N. (2001). Compensatory Smoking of low-yield cigarettes, in Smoking and tobacco control monograph No. 13: National Cancer Institute (U.S.). Risks Associated With Smoking Cigarettes With Low Machine-Measured Yields of Tar and Nicotine, Bethesda, MD: U.S. Department of Health and Human Services, USPHS, NIH, National Cancer Institute. p. 39 64.
5. Chen, B. T., Bechtold, W. E., Barr, E. B., Cheng Y-S., Mauderly, J. L., & Cuddihy, R. G. (1989). Comparison of cigarette smoke exposure atmospheres in different exposure and puffing modes. Inhalation Toxicology, 1, 331 347.
6. Kozlowski, L. T., & O'Connor R. J. (2002). Cigarette filter ventilation is a defective design because of misleading taste, bigger puffs, and blocked vents. Tobacco Control, 11 (Suppl I i40 i50.
7. Zacny, J. P., & Stitzer, M. L. (1994). Monograph 7: The FTC Cigarette Test Method for Determining Tar, Nicotine, and Carbon Monoxide Yields of U.S. Cigarettes. National Cancer Institute, 151 160.
8. Wynder, E. L., & Muscat, J. E. (1995). The changing epidemiology of smoking and lung cancer histology. Environmental Health Perspectives, 103 (S8 143 148.
9. International Commission on Radiological Protection 1994). Human respiratory tract model for radiological protection: A report of a task group of the international commission on radiological protection/international commission on radiological protection. In Annals of the ICRP., New York: Pergamon. p. 1 482.
10. Feng, S., Plunkett, S. E., Lam, K., Kapur, S., Muhammed, R., Jin, Y., Zimmermann, M., Mendes, P., Kinser, R., & Roethig, H. J. (2007). A new method for estimating the retention of selected smoke constituents in the respiratory tract of smokers during cigarette smoking. Inhalation Toxicology, 19, 169 179.
11. Landahl, H. D. (1950). On the removal of air-borne droplets by the human respiratory tract: I. The lung. Bulletin of Mathematical Physics, 12, 43 56.
12. Landahl, H. D., Tracewell, T. N., & Lassen, W. H. (1951). On the retention of air-borne particulates in the human lung: II. A. M. A. Archives of Industrial Hygiene and Occupational Medicine, 3 (4 359 366.
13. Lippman, M. (1977). Regional deposition of particles in the human respiratory tract. In D. Lee & S. Murphy (Eds.), Handbook of Physiology; Section IV, Environmental Physiology (pp. 213 232 Philadelphia, PA: Williams and Wilkins.
14. Gerrity, T. R., Lee, P. S., Hass, F. J., Marinelli, A., Peter, W., & Lourenco, R. V. (1979). Calculated deposition of inhaled particles in the airway generations of normal subjects. Journal of Applied Physiology, 47 (4 867 873.
15. Heyder, J., Gebhart, J., Rudolf, G., Schiller, C. F., & Stahlhofen, W. (1986). Deposition of particles in the human respiratory tract in the size range 0.005-15 um. Journal of Aerosol Science, 17 (5 811 825.
16. Martonen, T. B., & Katz, I. M. (1993). Deposition patterns of aerosolized drugs within human lungs: Effects of ventilatory parameters. Pharmaceutical Research, 10 (6 871 878.
17. Martonen, T. B., & Schroeter, J. D. (2003). Risk assessment dosimetry model for inhaled particulate matter: I. human subjects. Toxicology Letters, 138, 119 132.
18. Hoffmann, W., & Koblinger, L. (1992). Monte Carlo modeling of aerosol deposition in human lungs. Part III: Comparison with experimental data. Journal of Aerosol Science, 23 (1 51 63.
19. Segal, R. A., Martonen, T. B., & Kim, C. S. (2000). Comparison of computer simulations of total lung deposition to human subject data in healthy test subjects. Journal of the Air and Waste Management Society, 50, 1262 1268.
20. Hashish, A. H., Fleming, J. S., Conway, J., Halson, P., Moore, E., Williams, T. J., Bailey, A. G., Nassim, M., & Holgate, S. T. (1998). Lung deposition of particles by airway generation in healthy subjects: Three-dimensional radionuclide imaging and numerical model prediction. Journal of Aerosol Science, 29 (1/2 205 215.
21. Surgeon General 1988). Tobacco use as drug dependence, In The Health Consequences of Smoking: Nicotine Addiction: A Report of the Surgeon General, Rockville, MD: US Department of Health and Human Services. pp. 145 239.
22. Bernstein, D. M. (2004). A review of the influence of particle size, puff volume, and inhalation pattern on the deposition of cigarette smoke particles in the respiratory tract. Inhalation Toxicology, 16, 675 689.
23. Guyatt, A. R., Kirkham, J. T., Baldry, A. G., Dixon, M., & Cumming, G. (1989). How does smoking behavior alter during the smoking of a single cigarette? Pharmacology. Biochemistry and Behaviour, 33, 189 195.
24. Hammond, D., Fong, G., Cummings, K., O'Connor R, Giovino, G., & McNeil A. (2006). Cigarette yields and human exposure: A comparison of alternative smoking regimes. Cancer Epidemiology, Biomarkers, & Prevention, 15 (8 1495 1501.
25. Baker, R. R., & Dixon, M. (2006). The retention of tobacco smoke constituents in the human respiratory tract. Inhalation Toxicology, 17, 255 294.
26. Hammond, D., Fong, G. T., Cummings, M. K., & Hyland, A. (2005). Smoking topography, brand switching, and nicotine delivery: Results from an in vivo study. Cancer Epidemiology, Biomarkers & Prevention, 14 (6 1370 1375.
27. Landahl, H. D. (1963). Particle removal by the respiratory system note on the removal of airborne particulates by the human respiratory tract with particular reference to the role of diffusion. Bulletin of Mathematical Physics, 25, 29 39.
28. Blanchard, J. D., & Willeke, K. (1983). An inhalation system for characterizing total lung deposition of ultrafine particles. American Industrial Hygiene Association Journal, 44 (11 846 856.
29. Kim, C. S. (2000). Methods of calculating lung delivery and deposition of aerosol particles. Respiratory Care, 45 (6 695 711.
30. Dalla Valle, J. M., Orr, C., & Hinkle, B. L. (1954). The aggregation of aerosols. British Journal of Applied Physics, 5 (Suppl. 3 S198.
31. Langer, G., & Fisher, M. A. (1956). Concentration and particle size of cigarette smoke particles. A.M.A. Archives of Industrial Health, 13, 372.
32. Landahl, M. D., & Tracewell, T. N. (1957). An investigation of cigarette smoke as an aerosol with special reference to retention in lungs of human subjects. Transactions of the Illinois State Academy of Science, 50, 213.
33. Harris, E., & Kay, H. F. (1959). Size distribution of tobacco smoke particles. Nature (183 741.
34. Moriguchi, M. (1959). Studies of cigarette smoke particles. Japanese Journal of Hygiene, 14, 415 430.
35. Holmstedt, B., & Wallen, D. (1959). Drug administration by means of cigarettes. Archives Internationales de Pharmacodynamie et de Therapie, 119 (3-4 1959.
36. Holmes, J. C., Hardcastle, J. E., & Mitchell, R. I. (1959). The determination of particle size and electric charge distribution in cigarette smoke. Tobacco Science, 3, 148.
37. Harris, W. J. (1960). Size distribution of tobacco smoke droplets by a replica method. Nature, 186, 537.
38. Polydorova, M. (1961). An Attempt to Determine the Retention of Tobacco Smoke by Means of Membrane Filters, In CN Davies (Ed.), Inhaled Particles and Vapours, London: Pergamon Press. pp. 142 144.
39. Keith, C. H., & Derrick, J. C. (1961). Measurement of the particle size distribution and concentration if cigarette smoke by conifuge. Tobacco Science, 5, 84.
40. Berner, A., & Marek, J. (1967). Investigation of the distribution of several smoke constituents in smoke particles of various sizes. Fachliche Mitteilungen der Oesterreichischen Tabakregie, 7, 118.
41. Overton, J. R. (1967). Determination of the particle size and distribution by low-angle light scattering. Tobacco Science, 11, 58.
42. Harrington, L. R., & Mysels, K. J. (1971). A new instrument and method for analyzing the particle size of cigarette smoke. R.J.R. Tobacco 80.
43. Porstendorfer, J. (1973). Die Bestimmung Grossenverteilung von Aerosolen mitt Hilfe der Radioaktiven Markeirung un Der Spiralzentrifuge. Aerosol Science, 4, 345.
44. Porstendorfer, J., & Schraub, A. (1972). Concentration and mean particle size of the main and sidestream of cigarette smoke. Staub Reinhaltung der Luft, 32, 33.
45. Okada, T., & Matsunuma, K. (1974). Determination of particle-size distribution and concentration of a cigarette smoke by a light-scattering method. Journal of Colloid Interface Science, 48 (3 461 469.
46. Yoshida, T., Okuyama, K., Kousaka, Y., & Kida, Y. (1975). Change in particle size distributions of polydisperse aerosols undergoing Brownian coagulation. Journal of Chemical Engineering of Japan, 8, 317 322.
47. Carter, W. L., & Hasegawa, I. (1975). Fixation of tobacco smoke aerosols for size distribution studies. Journal of Colloid Interface Science, 53, 134.
48. Phalen, R. F., Cannon, W. C., & Esparza, D. (1976). Comparison of impaction, centrifugal separation and electron microscopy for sizing cigarette smoke, in fine particles, B. Y. Liu (Ed.), Academic Press. pp. 731.
49. Morie, G. P., & Baggett, M. S. (1977). Observations on size distribution of certain tobacco smoke components with respect to particle size. Beitrage Zur Tabakforschung International, 9, 72.
50. Leonard, R. E., & Kiefer, J. E. (1972). Coagulation rate of undiluted cigarette smoke. Tobacco Science, 16, 65.
51. Hinds, W. (1978). Size characteristics of cigarette smoke. American Industrial Hygiene Association Journal, 39, 48.
52. Ishizu, Y., & Okada, T. (1978). Determination of particle size distribution of small aerosol particles of unknown refractive index by a light-scattering method. Journal of Colloid Interface Science, 66 (2 234 239.
53. Creamer, R. N 1979). The light transmission of cigarette smoke and its contribution to the study of smoke kinetics, particle sizes and number of particles. in 33rd Tobacco Chemists Research Conference. Lexington, KY.
54. Holmberg, R. W. (1979). Determination of particle size in tobacco smoke inhalation exposure devices using methylcyanoacrylate fixation and scanning microscopy. Oak Ridge National Laboratory, 103.
55. Keith, C. H. (1982). Particle size studies on tobacco smoke. Beitrage Zur Tabakforschung International, 11, 123.
56. McCusker K, Hillier, F. C., Wilson, J. D., McLeod P. C., Sims, R., & Bone, R. C. (1982). Dilution of cigarette smoke for aerodynamic sizing with a SPART analyzer. Journal of Aerosol Science, 13, 103 110.
57. Schillinger, R. E. 1983). M.S. Thesis. Department of Chemical Engineering. Lexington: University of Kentucky :
58. Prodi, V., & Mularoni, A. (1984). Particulate Deposition in Smoking, in Smoking and the Lung, G. Cumming & G. Bonsignore (Eds.), New York: Plenum Press. pp. 249 282.
59. Chang, P. T., Peters, L. K., & Ueno, Y. (1985). Particle size distribution of mainstream smoke undergoing dilution. Aerosol Science and Technology, 4, 191 207.
60. Ingebrethsen, B. J., R. J. Reynolds Tobacco Co 1986). Aerosol studies of cigarette smoke. Recent Advances in Tobacco Science, 12, 54 142.
61. Hicks, J. F., Pritchard, J. N., Black, A., & Megaw, W. J. (1988). Measurements of growth due to condensation for some common aerosols. Journal of Aerosol Science, 20 (3 289 292.
62. Anderson, P. J., Wilson, J. D., & Hiller, F. C. (1989). Particle size distribution of mainstream tobacco and marijuana smoke: Analysis using the electrical aerosol analyzer. The American Review of Respiratory Disease, 140 (1 202 205.
63. Li, W., & Hopke, P. K. (1993). Initial size distributions and hygroscopicity of indoor combustion aerosol particles. Aerosol Science and Technology, 19, 305 316.
64. Chung, I.-P., & Dunn-Rankin, D. (1996). In situ light scattering measurements of mainstream and sidestream cigarette smoke. Aerosol Science and Technology, 24, 85 101.
65. Robinson, R. J., & Yu, C. P. (2001). Deposition of cigarette smoke particles in the human respiratory tract. Aerosol Science and Technology, 34, 202 215.
66. Jeffery, P. K. (1998). The development of large and small Airways. American Journal of Respiratory and Critical Care Medicine, 157 (5 S174 S180.
67. Kim, C. S., Hu, S. C., Dewitt, P., & Gerrity, T. R. (1996). Assessment of regional deposition of inhaled particles in human lungs by serial bolus delivery method. Journal of Applied Physiology, 81 (5 2203 2213.
68. Dalhamn, T., Edfors, M.-L., & Rylander, R. (1968). Retention of cigarette smoke components in human lungs. Archives of Environmental Health, 17, 746 748.
69. Mitchell, R. I. (1962). Controlled measurement of smoke-particle retention in the respiratory tract. The American Review of Respiratory Disease, 85, 526 533.
70. Hinds, W., Firs, W. M., Huber, G. L., & Shea, J. W. (1983). A method for measuring the respiratory deposition of cigarette smoke during smoking. American Industrial Hygiene Association Journal, 44, 113 118.
71. Chen, B. T., Namenyi, J., Yeh, H. C., Mauderly, J. L., & Cuddihy, R. G. (1990). Physical characterization of cigarette smoke aerosol generated from a Walton smoking machine. Aerosol Science and Technology, 12, 364 375.
72. Robinson, R. J., & Yu, C. P. (1999). Coagulation of cigarette smoke particles. Journal of Aerosol Science, 30 (4 533 548.
73. Cinkotai, F. F. (1968). The growth of cigarette smoke particles suspended on fine platinum wire in noise air. Beitrage Zur Tabakforschung International, 4, 189 195.
74. Ferron, G. A. (1977). The size fraction of soluble aerosol particles as a function of the humidity of the air. Application to the human respiratory tract. Journal of Aerosol Science, 8, 251 267.
75. Kousaka, Y., Okuyama, K., & Wang, C. (1982). Response of cigarette smoke particles to change in humidity. Journal of Chemical Engineering of Japan, 15 (1 75 76.
76. Robinson, R. J., & Yu, C. P. (1998). Theoretical analysis of hygroscopic growth rate of mainstream and sidestream cigarette smoke particles in the human respiratory tract. Aerosol Science and Technology, 28, 21 32.
77. Mitsakou, C., Helmis, C., & Housiadas, C. (2005). Eulerian modelling of lung deposition with sectional representation of aerosol dynamics. Aerosol Science, 36, 75 94.
78. Asgharian, B. (2004). A model of deposition of hygroscopic particles in the human lung. Aerosol Science and Technology, 38, 938 947.
79. Muller, W. J., Hess, G. D., & Scherer, P. W. (1990). A model of cigarette smoke deposition. American Industrial Hygiene Association Journal, 51 (5 245 256.
80. Martonen, T. B. (1992). Deposition patterns of cigarette smoke in human airways. American Industrial Hygiene Association Journal, 53 (1 6 18.
81. Martonen, T. B., & Musante, C. J. (2000). Importance of cloud motion on cigarette smoke deposition in lung airways. Inhalation Toxicology, 12 (Suppl. 4 261 280.
82. Broday, D. M., & Robinson, R. J. (2003). Application of cloud dynamics to dosimetry of cigarette smoke particles in the lungs. Aerosol Science and Technology, 37, 510 527.
83. McBride MJ, Guyatt, A. R., Kirkham, A. J. T., & Cumming, G. (1984). Assessment of smoking behaviour and ventilation with cigarettes of differing nicotine yields. Clinical Science, 67, 619 631.
84. Nil, R., & Battig, K. (1989). Separate effects of cigarette smoke yield and smoke taste on smoking behaviour. Psychopharmacology, 99, 54 59.
85. Djordjevic, M. V., Fan, J., Ferguson, S., & Hoffmann, D. (1995). Self-regulation of smoking intensity. Smoke yields of the low-nicotine, low-'tar' cigarettes. Carcinogenesis, 16 (9 2015 2021.
86. Tobin, M. J., & Sackner, M. A. (1982). Monitoring smoking patterns of low and high tar cigarettes with inductive plethysmography. American Review of Respiratory Disease, 126 (1-3 258 264.
87. Woodman, G., Newman, S. P., Pavia, D., & Clarke, S. W. (1987). The separate effects of tar and nicotine on the cigarette smoking maneuvre. European Journal of Respiratory Disease, 70, 316 321.
88. Woodman, G., Newman, S. P., Pavia, D., & Clarke, S. W. (1987). Response and acclimatisation of symptomless smokers on changing to a low tar, low nicotine cigarette. Thorax, 42, 336 341.
89. Scherer, G. (1999). Smoking behaviour and compensation: A review of the literature. Psychopharmacology, 145 (1 1 20.
90. Public Health Service National Institutes of Health & National Cancer Institute 2001). Smoking and Tobacco Control Monograph 13: Risks Associated with Smoking Cigarettes with Low Machine-Measured Yields of Tar and Nicotine. Bethesda, MD: U.S. Department of health and human services. 1 236.
91. Proctor, C. (Undated (after 1990 Position Paper Regarding the Effect of Smoking Behaviour on Smoke Deliveries. British American Tobacco.: Bates No. 401861750/1964. http://tobaccodocuments.org/bat_cdc/8910.html.
92. Fant, R. V., Schuh, K. J., & Stitzer, M. L. (1995). Response to smoking as a function of prior smoking amounts. Psychopharmacology, 119 (4 385 390.
93. Robinson, J. C., Young, J. C., & Rickert, W. S. (1982). A comparative study of the amount of smoke absorbed from low yield ('Less Hazardous') cigarettes. Part 1. Non-invasive measures. British Journal of Addiction, 77, 383 397.
94. Hee, J., Calais, F., Momas, I., Laurent, A. M., Min, S., Molinier, P., Chastagnier, M., Claude, J. R., & Festy, B. (1995). Smoker's behaviour and exposure according to cigarette yield and smoking experience. Pharmacology Biochemistry and Behaviour, 52 (1 195 203.
95. Tobin, M. J., Schneider, A. W., & Ma S 1982). Breathing pattern during and after smoking cigarettes. Clinical Science, 63, 473 483.
96. Hoffmann, D., Hoffmann, I., & El-Bayoumy, K. (2001). The Less Harmful Cigarette: A Controversial Issue. A Tribute to Ernst L. Wynder. Chemical Research in Toxicology, 14 (7 767 790.
97. Creighton, D. (1971). The Effect of Depth of Inhalation of Cigarette Smoke on Human Physiological Response. British American Tobacco 18.
98. "I.M." (date unknown). I Wonder if increasing depth of inhalation and/or breath holding could possibly increase nicotine intake for the de-nicotinized cigt. up to that of the regular cigt? (Handwritten Note), RJR Tobacco archives retrieved June 2006.
99. Creighton, D., & Backhurst, J. (1973). Retention of Smoke - Investigation of Modified Method. British American Tobacco 18.
100. Creighton, D. (1978). Retention of Tobacco Smoke in the Human Respiratory System. British American Tobacco 20.
101. UNITED STATES OF AMERICA v. PHILIP MORRIS USA INC 1999). Civil Action No. 99-CV-2496 (GK). District of Colombia.
102. Richardson, R. B. (1977). Factors Influencing the Uptake of Water by Smoke. British American Tobacco.
103. Ingebrethsen, B. J. (1986). Evolution of the particle size distribution of mainstream cigarette smoke during a puff. Aerosol Science and Technology, 5 (4 423 433.
104. Rickert, W. S., Robinson, J. C., Young, J. C., Collishaw, N. E., & Bray, D. F. (1983). A comparison of the yields of tar, nicotine, and carbon monoxide of 36 brands of Canadian cigarettes tested under three conditions. Preventive Medicine, 12, 682 694.
105. Kozlowski, L. T., & O'Connor R. J. (2000). Official cigarette tar tests are misleading: Use a two-stage, compensating test. Lancet, 355 (9221 2159 2161.
106. Lastborn, L., & Camner, P. (2000). Deposition and clearance of particles in the human lung. Scandinavian Journal of Environment, Work and Health, 26 (Suppl. 1 23 27.
107. Lazaridis, M., Broday, D. M., Hov, O., & Georgopoulos, P. G. (2001). Integrated exposure and dose modeling and analysis system. 3. Deposition of inhaled particles in the human respiratory tract. Environmental Science and Technology, 35 (18 3727 3734.
108. Giacomelli-Maltoni, G., Melandri, C., Prodi, V., & Tarroni, G. (1972). Deposition efficiency of monodisperse particles in human respiratory tract. American Industrial Hygiene Association Journal, 33 (9 603 610.
109. Hoffmann, D., Djordjevic, M. V., & Hoffmann, I. (1997). The changing cigarette. Preventive Medicine, 26, 427 434.