Grey matter abnormalities in first-episode schizophrenia and affective psychosis

British Journal of Psychiatry

Volumn 191, Issue SUPPL. 51, 2007, Pages

  Morgan, Kevin D ^a   Dazzan, Paola ^b   Orr, Kenneth G ^c   Hutchinson, Gerard ^d   Chitnis, Xavier ^b   Suckling, John ^e   Lythgoe, David ^b   Pollock, Sarah Jayne ^f   Rossell, Susan ^f   Shapleske, Jane ^f   Fearon, Paul ^b   Morgan, Craig ^b   David, Anthony ^b   McGuire, Philip K ^b   Jones, Peter B ^e   Leff, Julian ^b   Murray, Robin M ^b  

^a UNIVERSITY OF WESTMINSTER   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^d UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f FULBOURN HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLEPTIC AGENT;

ADOLESCENT; ADULT; AFFECTIVE PSYCHOSIS; AGED; ARTICLE; BRAIN REGION; BRAIN SIZE; CINGULATE GYRUS; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GRAY MATTER; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; SCHIZOPHRENIA; TEMPORAL LOBE; BRAIN; BRAIN CORTEX; BRAIN MAPPING; BRAIN VENTRICLE; DRUG ADMINISTRATION; IMAGE PROCESSING; METHODOLOGY; MIDDLE AGED; PATHOLOGY; TIME;

ADOLESCENT; ADULT; AFFECTIVE DISORDERS, PSYCHOTIC; AGED; ANTIPSYCHOTIC AGENTS; BRAIN; BRAIN MAPPING; CEREBRAL CORTEX; CEREBRAL VENTRICLES; DRUG ADMINISTRATION SCHEDULE; FEMALE; GYRUS CINGULI; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SCHIZOPHRENIA; TIME FACTORS;

EID: 37249007644     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.191.51.s111     Document Type: Article

References (28)

1. Bebbington, P. & Nayani, T. (1995) The psychosis screening questionnaire. International Journal of Methods in Psychiatry Research, 5, 11-19.
2. Bremner, J. D., Vythilingam, M., Vermetten, E., et al (2002) Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry, 51, 273-279.
3. Bullmore, E. T., Suckling, J., Overmeyer, S., et al (1999) Global voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Transactions on Medical Imaging, 18, 32-42.
4. Cahn, W., Pol, H. E. H., Lems, E. B. T. E., et al (2002) Brain volume changes in first-episode schizophrenia - A 1-year follow-up study. Archives of General Psychiatry, 59, 1002-1010.
5. Corson, P. W., O'Leary, D. S., Miller, D. D., et al (1999) Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics. American Journal of Psychiatry, 156, 1200-1204.
6. Corson, P. W., O'Leary, D. S., Miller, D. D., et al (2002) The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: A comparison between the neuroleptic-naive and medicated states. Biological Psychiatry, 52, 855-862.
7. Dazzan, P., Morgan, K. D., Orr. K. G., et al (2004) The structural brain correlates of neurological soft signs in ÆSOP first-episode psychoses study. Brain, 127 (pt 1), 143-53.
8. Dazzan, P., Morgan, K., Orr, K.G., et al (2005) Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: The ÆSOP study. Neuropsychopharmacology, 30, 765-774.
9. Fannon, D., Chitnis, X., Doku, V., et al (2000a) Features of structural brain abnormality detected in first-episode psychosis. American Journal of Psychiatry, 157, 1829-1834.
10. Fannon, D., Tennakoon, L., O'Ceallaigh, S., et al (2000b) Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings. British Journal of Psychiatry, 177, 354-359.
11. Garver, D. L., Holcomb, J. A. & Christensen, J. D. (2005) Cerebral cortical gray expansion associated with two second-generation antipsychotics. Biological Psychiatry, 58, 62-66.
12. Job, D. E., Whalley, H. C., McConnell, S., et al (2002) Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry. Neuroimage, 17, 880-889.
13. Kasai, K., Shenton, M. E., Salisbury, D. F., et al (2003a) Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. American Journal of Psychiatry, 160, 156-164.
14. Kasai, K., Shenton, M. E., Salisbury, D. F., et al (2003b) Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosis. Archives of General Psychiatry, 60, 1069-1077.
15. Kubicki, M., Shenton, M. E., Salisbury, D. F., et al (2002) Voxel-based morphometric analysis of gray matter in first episode schizophrenia. Neuroimage, 17, 1711-1719.
16. Lawrie, S. M. & Abukmeil, S. S. (1998) Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. British Journal of Psychiatry, 172, 110-120.
17. Lieberman, J. A., Tollefson, G. D., Charles, C., et al (2005) Antipsychotic drug effects on brain morphology in first onset psychosis. Archives of General Psychiatry, 62, 361-370.
18. McDonald, C., Bullmore, E. T., Sham, P. C., et al (2004) Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Archives of General Psychiatry, 61, 974-984.
19. Morgan, C., Dazzan, P., Morgan, K., et al (2006) First episode psychosis and ethnicity: initial findings from the ÆSOP study. World Psychiatry, 5, 40-46.
20. Nelson, H. & Willison, R. (1991) National Adult Reading Test (part II) Test Manual. nfer-Nelson.
21. Onitsuka, T., Shenton, M. E., Kasai, K., et al (2003) Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia. Archives of General Psychiatry, 60, 349-355.
22. Pantelis, C., Velakoulis, D., McGorry, P. D., et al (2003) Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet, 361, 281-288.
23. Sassi, R. B., Brambilla, P., Hatch, J. P., et al (2004) Reduced left anterior cingulate volumes in untreated bipolar patients. Biological Psychiatry, 56, 467-475.
24. Sigmundsson, T., Suckling, J., Maier, M., et al (2001) Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. American Journal of Psychiatry, 158, 234-243.
25. Suckling, J., Sigmundsson, T., Greenwood, K., et al (1996) A modified fuzzy clustering algorithm for operator independent brain tissue classification of dual echo MR images. Magnetic Resonance Imaging, 17, 1065-1076.
26. Wing, J. K. & Sturt, E. (1978) The PSE-ID-CATEGO System: Supplementary Manual. Medical Research Council.
27. World Health Organization (1992) ICD-10 Classification of Mental and Behavioural Disorders.WHO.
28. World Health Organization (1994) Schedules for Clinical Assessment in Neuropsychiatry (SCAN 2.0). WHO.