Investigating the pharmacodynamics of ketamine in children

Paediatric Anaesthesia

Volumn 18, Issue 1, 2008, Pages 36-42

  Herd, David W ^a   Anderson, Brian J ^b   Keene, Natalie A ^c   Holford, Nicholas H G ^b  

^a STARSHIP CHILDREN S HOSPITAL   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c WAIKATO HOSPITAL   (New Zealand)

Author keywords

Children; Ketamine; Pharmacodynamics; Procedural sedation

Indexed keywords

KETAMINE;

ADOLESCENT; ANESTHESIA; AROUSAL; ARTICLE; BLOOD; BODY WEIGHT; CHILD; EMERGENCY WARD; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MEMORY; PHARMACODYNAMICS; PRIORITY JOURNAL; RECALL; SEDATION; SURGICAL TECHNIQUE; VIDEORECORDING;

ADOLESCENT; ALGORITHMS; ANESTHETICS, DISSOCIATIVE; AROUSAL; CHILD; CHILD, PRESCHOOL; CONSCIOUSNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFANT; KETAMINE; LOGISTIC MODELS; MALE; MEMORY; MENTAL RECALL; MODELS, STATISTICAL;

EID: 37249006342     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2007.02384.x     Document Type: Article

References (21)

1. Idvall J, Ahlgren I, Aronsen KR et al. Ketamine infusions: pharmacokinetics and clinical effects. Br J Anaesth 1979 51 : 1167 1173.
2. Schuttler J, Stanski DR, White PF et al. Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man. J Pharmacokinet Biopharm 1987 15 : 241 253.
3. Grant IS, Nimmo WS, McNicol LR et al. Ketamine disposition in children and adults. Br J Anaesth 1983 55 : 1107 1111.
4. Hartvig P, Larsson E, Joachimsson PO. Postoperative analgesia and sedation following pediatric cardiac surgery using a constant infusion of ketamine. J Cardiothorac Vasc Anesth 1993 7 : 148 153.
5. Contreras PC, Monahan JB, Lanthorn TH et al. Phencyclidine. Physiological actions, interactions with excitatory amino acids and endogenous ligands. Mol Neurobiol 1987 1 : 191 211.
6. Herd D, Anderson BJ. Ketamine disposition in children presenting for procedural sedation and analgesia in a children's emergency. Pediatr Anesth 2007 17 : 622 629.
7. Hoffman GM, Nowakowski R, Troshynski TJ et al. Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model. Pediatrics 2002 109 : 236 243.
8. Beal SL, Sheiner LB, Boeckmann A. Nonmem User's Guide. San Francisco : Division of Pharmacology, University of California, 1999.
9. Efron B, Tibshirani R. Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy. Stat Sci 1986 1 : 54 77.
10. Davidson AJ. Measuring anesthesia in children using the EEG. Pediatr Anesth 2006 16 : 374 387.
11. Hastie TJ, Botha JL, Schnitzler CM. Regression with an ordered categorical response. Stat Med 1989 8 : 785 794.
12. Zeger SL, Liang KY. An overview of methods for the analysis of longitudinal data. Stat Med 1992 11 : 1825 1839.
13. Sheiner LB. A new approach to the analysis of analgesic drug trials, illustrated with bromfenac data. Clin Pharmacol Ther 1994 56 : 309 322.
14. Boni J, Korth-Bradley J, McGoldrick K et al. Pharmacokinetic and pharmacodynamic action of etodolac in patients after oral surgery. J Clin Pharmacol 1999 39 : 729 737.
15. Mandema JW, Stanski DR. Population pharmacodynamic model for ketorolac analgesia. Clin Pharmacol Ther 1996 60 : 619 635.
16. Tannenbaum SJ, Holford NH, Lee H et al. Simulation of correlated continuous and categorical variables using a single multivariate distribution. J Pharmacokinet Pharmacodyn 2006 33 : 773 794.
17. Lu W, Ramsay JG, Bailey JM. Reliability of pharmacodynamic analysis by logistic regression: mixed-effects modeling. Anesthesiology 2003 99 : 1255 1262.
18. Leung LY, Baillie TA. Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J Med Chem 1986 29 : 2396 2399.
19. Herd DW, Anderson BJ, Holford NHG. Modelling the norketamine metabolite in children and the implications for analgesia. Pediatr Anesth 2007 17 : 831 840.
20. White PF, Way WL, Trevor AJ. Ketamine - its pharmacology and therapeutic uses. Anesthesiology 1982 56 : 119 136.
21. Stephenson T. How children's responses to drugs differ from adults. Br J Clin Pharmacol 2005 59 : 670 673.