Opioid Use in Palliative Care of Children and Young People with Cancer

Journal of Pediatrics

Volumn 152, Issue 1, 2008, Pages 39-44

  Hewitt, Martin ^b   Goldman, Ann ^c   Collins, Gary S ^d   Childs, Margaret ^d   Hain, Richard ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

^c GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^d United Kingdom Children's Cancer Study Group   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIAMORPHINE; FENTANYL; MORPHINE; OPIATE; PARACETAMOL;

ADOLESCENT; ADULT; ARTICLE; CANCER; CHILD; CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; HEALTH SURVEY; HUMAN; INFANT; INFORMATION PROCESSING; KRUSKAL WALLIS TEST; MAJOR CLINICAL STUDY; MALE; MEDICAL PRACTICE; PALLIATIVE THERAPY; PRESCRIPTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; RANK SUM TEST; SOLID TUMOR; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; UNITED KINGDOM;

ADMINISTRATION, ORAL; ADMINISTRATION, RECTAL; ADOLESCENT; ADULT; ANALGESICS, OPIOID; CHILD; CHILD, PRESCHOOL; FEMALE; FENTANYL; GREAT BRITAIN; HEROIN; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; MORPHINE; NEOPLASMS; PAIN; PALLIATIVE CARE; PRESCRIPTIONS, DRUG; PROSPECTIVE STUDIES; QUESTIONNAIRES; RESEARCH DESIGN; THERAPEUTIC EQUIVALENCY;

EID: 37249006244     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2007.07.005     Document Type: Article

References (37)

1. National Institute for Health and Clinical Excellence. Palliative Care. Guidance on cancer services: improving outcomes in children and young people with cancer (2005), National Institute for Health and Clinical Excellence, London 81-86 Cancer NCCf, editor.
2. Ablett S., and Pinkerton C.R. Recruiting children into cancer trials-role of the United Kingdom Children's Cancer Study Group (UKCCSG). Br J Cancer 88 (2003) 1661-1665
3. Mystakidou K., Parpa E., Katsouda E., Galanos A., and Vlahos L. Influence of pain and quality of life on desire for hastened death in patients with advanced cancer. Int J Palliat Nurs 10 (2004) 476-483
4. Drake R., Frost J., and Collins J.J. The symptoms of dying children. J Pain Symptom Manage 26 (2003) 594-603
5. Wolfe J., Grier H.E., Klar N., Levin S.B., Ellenbogen J.M., Salem-Schatz S., et al. Symptoms and suffering at the end of life in children with cancer. N Engl J Med 342 (2000) 326-333
6. Hongo T., Watanabe C., Okada S., Inoue N., Yajima S., Fujii Y., et al. Analysis of the circumstances at the end of life in children with cancer: symptoms, suffering and acceptance. Pediatr Int 45 (2003) 60-64
7. Goldman A., Hewitt M., Collins G.S., Childs M., and Hain R.D.W. Symptoms in children/young people with progressive malignant disease - a UKCCSG/PONF survey. Pediatrics 117 (2006) e1179-e1186
8. Drake R., and Hain R.D.W. Pain: pharmacological management. In: Goldman A., Hain R., and Liben S. (Eds). Oxford Textbook of Palliative Care in Children. 1 ed. (2006), Oxford University Press, Oxford, UK 304-331
9. Hain R.D., Miser A., Devins M., and Wallace W.H. Strong opioids in pediatric palliative medicine. Paediatr Drugs 7 (2005) 1-9
10. World Health Organisation. Guidelines for analgesic drug therapy. Cancer Pain Relief and Palliative Care in Children (1998), WHO/IASP, Geneva 24-28
11. DiCiccio T., and Efron B. Bootstrap confidence intervals. Statistical Science 11 (1996) 189-228
12. Collins J.J., Dunkel I.J., Gupta S.K., Inturrisi C.E., Lapin J., Palmer L.N., et al. Transdermal fentanyl in children with cancer pain: feasibility, tolerability, and pharmacokinetic correlates. J Pediatr 134 (1999) 319-323
13. Noyes M., and Irving H. The use of transdermal fentanyl in pediatric oncology palliative care. Am J Hosp Palliat Care 18 (2001) 411-416
14. Klepstad P., Dale O., Kaasa S., Zahlsen K., Aamo T., Fayers P., et al. Influences on serum concentrations of morphine, M6G and M3G during routine clinical drug monitoring: a prospective survey in 300 adult cancer patients. Acta Anaesthesiol Scand 47 (2003) 725-731
15. McQuay H.J., Carroll D., Faura C.C., Gavaghan D.J., Hand C.W., and Moore R.A. Oral morphine in cancer pain: influences on morphine and metabolite concentration. Clin Pharmacol Ther 48 (1990) 236-244
16. Hunt A., Joel S., Dick G., and Goldman A. Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustained-release tablets for cancer pain. J Pediatr 135 (1999) 47-55
17. Zernikow B., and Lindena G. Long-acting morphine for pain control in paediatric oncology. Med Pediatr Oncol 36 (2001) 451-458
18. Heger S., Maier C., Otter K., Helwig U., and Suttorp M. Morphine induced allodynia in a child with brain tumour. BMJ 319 (1999) 627-629
19. Graves D.A., Baumann T.J., Bennett R.L., Batenhorst R.L., Griffen W.O., Plumlee J.E., et al. Extraordinary analgesic requirement in a patient previously unexposed to narcotics. Drug Intell Clin Pharm 18 (1984) 598-600
20. Lo S.L., and Coleman R.R. Exceptionally high narcotic analgesic requirements in a terminally ill cancer patient. Clin Pharm 5 (1986) 828-832
21. Twycross R. Paradoxical pain. BMJ 306 6880 (1993) 793
22. King T., Gardell L.R., Wang R., Vardanyan A., Ossipov M.H., Philip Malan Jr. T., et al. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain 116 (2005) 276-288
23. Ossipov M.H., Lai J., King T., Vanderah T.W., and Porreca F. Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers 80 (2005) 319-324
24. Faura C.C., Collins S.L., Moore R.A., and McQuay H.J. Systematic review of factors affecting the ratios of morphine and its major metabolites. Pain 74 (1998) 43-53
25. Collins J.J., Grier H.E., Kinney H.C., and Berde C.B. Control of severe pain in children with terminal malignancy. J Pediatr 126 (1995) 653-657
26. Mercadante S. Cancer pain management in children. Palliat Med 18 (2004) 654-662
27. Hain R.D.W., Hardcastle A., Pinkerton C.R., and Aherne G.W. Morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children. Br J Clin Pharmacol 48 (1999) 37-42
28. Hanks G.W., Hoskin P.J., Aherne G.W., Turner P., and Poulain P. Explanation for potency of repeated oral doses of morphine?. Lancet 2 (1987) 723-726
29. Hoskin P.J., Hanks G.W., Aherne G.W., Chapman D., Littleton P., and Filshie J. The bioavailability and pharmacokinetics of morphine after intravenous oral and buccal administration in healthy volunteers. Br J Clin Pharmacol 27 (1989) 499-505
30. Hoskin P.J., Hanks G.W., Heron C.W., Aherne G.W., and Chapman D. M6G and its analgesic action in chronic use. Clin J Pain 5 (1989) 199-200
31. McDonald A.J., and Cooper M.G. Patient-controlled analgesia: an appropriate method of pain control in children. Paediatr Drugs 3 (2001) 273-284
32. Baumann T.J., Batenhorst R.L., Graves D.A., Foster T.S., and Bennett R.L. Patient-controlled analgesia in the terminally ill cancer patient. Drug Intell Clin Pharm 20 (1986) 297-301
33. Kornick C.A., Santiago-Palma J., Khojainova N., Primavera L.H., Payne R., and Manfredi P.L. A safe and effective method for converting cancer patients from intravenous to transdermal fentanyl. Cancer 92 (2001) 3056-3061
34. Pasero C., and McCaffery M. Authorized and unauthorized use of PCA pumps: clarifying the use of patient-controlled analgesia, in light of recent alerts. Am J Nurs 105 (2005) 30-31 33
35. Schechter N.L., Weisman S.J., Rosenblum M., Bernstein B., and Conard P.L. The use of oral transmucosal fentanyl citrate for painful procedures in children. Pediatrics 95 (1995) 335-339
36. Wheeler M., Birmingham P.K., Dsida R.M., Wang Z., Cote C.J., and Avram M.J. Uptake pharmacokinetics of the Fentanyl Oralet in children scheduled for central venous access removal: implications for the timing of initiating painful procedures. Paediatr Anaesth 12 (2002) 594-599
37. Kokki H., Rasanen I., Reinikainen M., Suhonen P., Vanamo K., and Ojanpera I. Pharmacokinetics of oxycodone after intravenous, buccal, intramuscular and gastric administration in children. Clin Pharmacokinet 43 (2004) 613-622